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    ASIP agouti signaling protein [ Equus caballus (horse) ]

    Gene ID: 100054335, updated on 17-Aug-2024

    Summary

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    Official Symbol
    ASIPprovided by VGNC
    Official Full Name
    agouti signaling proteinprovided by VGNC
    Primary source
    VGNC:VGNC:15585
    See related
    Ensembl:ENSECAG00000004241
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See ASIP in Genome Data Viewer
    Location:
    chromosome: 22
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 22 NC_009165.3 (26009341..26072655)

    Chromosome 22 - NC_009165.3Genomic Context describing neighboring genes Neighboring gene RNA-binding protein Raly Neighboring gene eukaryotic translation initiation factor 2 subunit beta Neighboring gene uncharacterized LOC111770065 Neighboring gene adenosylhomocysteinase Neighboring gene uncharacterized LOC106782400

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009165.3 Chromosome 22 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An Independent Locus Upstream of ASIP Controls Variation in the Shade of the Bay Coat Colour in Horses. Corbin LJ, et al. Genes (Basel), 2020 May 30. PMID 32486210, Free PMC Article
    2. The MC1R and ASIP Coat Color Loci May Impact Behavior in the Horse. Jacobs LN, et al. J Hered, 2016 May. PMID 26884605, Free PMC Article
    3. Variation in the MC1R, ASIP, and MATP genes responsible for coat color in Kiso horse as determined by SNaPshot™ genotyping. Nakamura K, et al. J Vet Med Sci, 2019 Jan 8. PMID 30464090, Free PMC Article
    4. Mutations in the agouti (ASIP), the extension (MC1R), and the brown (TYRP1) loci and their association to coat color phenotypes in horses (Equus caballus). Rieder S, et al. Mamm Genome, 2001 Jun. PMID 11353392
    5. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. An Independent Locus Upstream of ASIP Controls Variation in the Shade of the Bay Coat Colour in Horses.
      Title: An Independent Locus Upstream of ASIP Controls Variation in the Shade of the Bay Coat Colour in Horses.
    2. variation in MC1R, ASIP, and MATP genes in horse coat color
      Title: Variation in the MC1R, ASIP, and MATP genes responsible for coat color in Kiso horse as determined by SNaPshot™ genotyping.
    3. there was a correlation between the recessive ASIP allele and a more independent temperament
      Title: The MC1R and ASIP Coat Color Loci May Impact Behavior in the Horse.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables melanocortin receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables neuropeptide hormone activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hormone-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in melanosome organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of melanin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    agouti-signaling protein
    Names
    ASP
    agouti signaling protein, nonagouti homolog
    agouti switch protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164017.1 → NP_001157489.1  agouti-signaling protein precursor

      See identical proteins and their annotated locations for NP_001157489.1

      Status: PROVISIONAL

      Source sequence(s)
      PJAA01000023
      UniProtKB/Swiss-Prot
      Q95MP2
      Conserved Domains (1) summary
      smart00792
      Location:6 → 129
      Agouti; Agouti protein

    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009165.3 Reference EquCab3.0 Primary Assembly

      Range
      26009341..26072655
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023625920.1 → XP_023481688.1  agouti-signaling protein isoform X1

      UniProtKB/Swiss-Prot
      Q95MP2
      Related
      ENSECAP00000059028.1, ENSECAT00000112645.1
      Conserved Domains (1) summary
      smart00792
      Location:6 → 129
      Agouti; Agouti protein

    RNA

    1. XR_002802718.1 RNA Sequence

    2. XR_001379462.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95MP2.1 GenPept UniProtKB/Swiss-Prot:Q95MP2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.