asb12a ankyrin repeat and SOCS box-containing 12a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: asb12aprovided by ZNC
Official Full Name: ankyrin repeat and SOCS box-containing 12aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-1647
See related: Ensembl:ENSDARG00000017086 AllianceGenome:ZFIN:ZDB-GENE-030131-1647
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: asb12; wu:fb77b07
Summary: Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within intracellular signal transduction. Predicted to be part of ubiquitin ligase complex. Is expressed in female organism. Orthologous to human ASB12 (ankyrin repeat and SOCS box containing 12). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (22021142..22027358, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (21517342..21523558, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb77b07.x1 (e-PCR)
- UniSTS:191338

fb77b07.x1 (e-PCR)
- UniSTS:191339

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
contributes_to ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ankyrin repeat and SOCS box protein 12a

Names: ankyrin repeat and SOCS box-containing protein 12; ankyrin repeat and SOCS box-containing protein 12a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001126376.1 → NP_001119848.1 ankyrin repeat and SOCS box protein 12a

Status: VALIDATED

Source sequence(s)

CR812469

UniProtKB/TrEMBL

A0A8M1NHA8, A2CEZ8

Related

ENSDARP00000014061.7, ENSDART00000023306.8

Conserved Domains (5) summary

cd00204
Location:55 → 181

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

pfam12796
Location:57 → 148

Ank_2; Ankyrin repeats (3 copies)

pfam13637
Location:119 → 181

Ank_4; Ankyrin repeats (many copies)

sd00045
Location:55 → 83

ANK; ANK repeat [structural motif]

cl02533
Location:257 → 297

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...