K11H12.8 Growth hormone-inducible transmembrane protein;Ilv operon leader peptide;Secreted protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: K11H12.8
Official Full Name: Growth hormone-inducible transmembrane protein;Ilv operon leader peptide;Secreted protein
Primary source: WormBase:WBGene00019664
Locus tag: CELE_K11H12.8
See related: AllianceGenome:WB:WBGene00019664
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable calcium channel activity. Predicted to be involved in calcium export from the mitochondrion and inner mitochondrial membrane organization. Predicted to be located in membrane. Predicted to be active in mitochondrial inner membrane. Orthologous to human GHITM (growth hormone inducible transmembrane protein). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See K11H12.8 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (655390..658626)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

K11H12.8 (e-PCR)
- UniSTS:319516

K11H12.2 (e-PCR)
- UniSTS:316064

STS4-101 (e-PCR)
- UniSTS:242088

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium export from the mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
involved_in inner mitochondrial membrane organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Growth hormone-inducible transmembrane protein;Ilv operon leader peptide;Secreted protein

NP_001368206.1

Confirmed by transcript evidence

NP_001368207.1

Confirmed by transcript evidence

NP_001379948.1

Partially confirmed by transcript evidence

NP_741296.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

655390..658626

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171248.6 → NP_741296.1 Growth hormone-inducible transmembrane protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741296.1

Status: REVIEWED

UniProtKB/TrEMBL

P91373

Conserved Domains (1) summary

cd10431
Location:71 → 340

GHITM; Growth-hormone inducible transmembrane protein
NM_001392248.1 → NP_001379948.1 Secreted protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

H2L016
NM_001380014.1 → NP_001368206.1 Growth hormone-inducible transmembrane protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PLI6

Conserved Domains (1) summary

cl00473
Location:1 → 185

BI-1-like; BAX inhibitor (BI)-1/YccA-like protein family
NM_001380015.1 → NP_001368207.1 Ilv operon leader peptide [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

U4PQU7

Conserved Domains (1) summary

cl00473
Location:1 → 25

BI-1-like; BAX inhibitor (BI)-1/YccA-like protein family