apm-1 MHD domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: apm-1
Official Full Name: MHD domain-containing protein
Primary source: WormBase:WBGene00000150
Locus tag: CELE_F55A12.7
See related: AllianceGenome:WB:WBGene00000150
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable clathrin adaptor activity. Involved in apical protein localization. Predicted to be located in membrane. Predicted to be part of clathrin adaptor complex. Predicted to be active in clathrin-coated vesicle. Is expressed in several structures, including head; hypodermis; intestine; pharyngeal-intestinal valve; and vulva. Orthologous to human AP1M1 (adaptor related protein complex 1 subunit mu 1) and AP1M2 (adaptor related protein complex 1 subunit mu 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See apm-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 9

Sequence:: Chromosome: I; NC_003279.8 (5342180..5344724, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F55A12.7 (e-PCR)
- UniSTS:311810

STS1-255 (e-PCR)
- UniSTS:241748

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apical protein localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in innate immune response	HEP more info	PubMed
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
is_active_in clathrin-coated vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MHD domain-containing protein

NP_491572.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

5342180..5344724 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_059171.9 → NP_491572.2 MHD domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491572.2

Status: REVIEWED

UniProtKB/TrEMBL

O01755

Conserved Domains (2) summary

cd09250
Location:152 → 424

AP-1_Mu1_Cterm; C-terminal domain of medium Mu1 subunit in clathrin-associated adaptor protein (AP) complex AP-1

cd14835
Location:4 → 142

AP1_Mu_N; AP-1 complex subunit mu N-terminal domain