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    Cnga1 cyclic nucleotide gated channel alpha 1 [ Mus musculus (house mouse) ]

    Gene ID: 12788, updated on 27-Nov-2024

    Summary

    Official Symbol
    Cnga1provided by MGI
    Official Full Name
    cyclic nucleotide gated channel alpha 1provided by MGI
    Primary source
    MGI:MGI:88436
    See related
    Ensembl:ENSMUSG00000067220 AllianceGenome:MGI:88436
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cncg
    Summary
    Predicted to enable cyclic nucleotide binding activity and intracellularly cyclic nucleotide-activated monoatomic cation channel activity. Predicted to be involved in membrane depolarization; monoatomic cation transport; and regulation of cytosolic calcium ion concentration. Located in photoreceptor outer segment membrane and rod photoreceptor outer segment. Is expressed in photoreceptor layer outer segment; retina; and retina outer nuclear layer. Used to study retinitis pigmentosa 49. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 49. Orthologous to human CNGA1 (cyclic nucleotide gated channel subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
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    Genomic context

    See Cnga1 in Genome Data Viewer
    Location:
    5 C3.2; 5 38.44 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (72761039..72800095, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (72603696..72642752, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 10 (sodium/bile acid cotransporter family), pseudogene Neighboring gene zygote arrest 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:73025974-73026235 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:73027370-73027613 Neighboring gene predicted gene 5297 Neighboring gene NIPA-like domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E3582 Neighboring gene TXK tyrosine kinase

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cAMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cAMP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables cGMP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cGMP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables cGMP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables intracellularly cAMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables intracellularly cAMP-activated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables intracellularly cAMP-activated cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables intracellularly cGMP-activated cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables intracellularly cGMP-activated cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables intracellularly cGMP-activated cation channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables sodium channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in membrane depolarization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in monoatomic cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cytosolic calcium ion concentration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in sodium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sodium ion transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of intracellular cyclic nucleotide activated cation channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of intracellular cyclic nucleotide activated cation channel complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in photoreceptor outer segment membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in rod photoreceptor outer segment IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    cyclic nucleotide-gated channel alpha-1; cGMP-gated cation channel alpha-1
    Names
    CNG channel alpha-1
    CNG-1
    CNG1
    cyclic nucleotide gated channel, cGMP gated
    cyclic nucleotide-gated cation channel 1
    cyclic nucleotide-gated channel, photoreceptor
    rod photoreceptor cGMP-gated cation channel subunit alpha
    rod photoreceptor cGMP-gated channel subunit alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007723.2NP_031749.2  cyclic nucleotide-gated channel alpha-1

      See identical proteins and their annotated locations for NP_031749.2

      Status: VALIDATED

      Source sequence(s)
      AC122733, BI738168, BI871897, CO423854, CX564336
      Consensus CDS
      CCDS19333.1
      UniProtKB/Swiss-Prot
      B9EJ09, P29974, Q60776
      Related
      ENSMUSP00000084464.6, ENSMUST00000087213.12
      Conserved Domains (4) summary
      COG0664
      Location:465621
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
      cd00038
      Location:471587
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:179399
      Ion_trans; Ion transport protein
      pfam16526
      Location:587657
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      72761039..72800095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006503709.1XP_006503772.1  cGMP-gated cation channel alpha-1 isoform X1

      Conserved Domains (3) summary
      cd00038
      Location:486602
      CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
      pfam00520
      Location:172414
      Ion_trans; Ion transport protein
      pfam16526
      Location:602671
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels