Amotl2 angiomotin-like 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Amotl2provided by MGI
Official Full Name: angiomotin-like 2provided by MGI
Primary source: MGI:MGI:1929286
See related: Ensembl:ENSMUSG00000032531 AllianceGenome:MGI:1929286
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lccp; MASCOT; mKIAA0989
Summary: Enables actin filament binding activity and identical protein binding activity. Involved in endothelial cell morphogenesis. Located in apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Is expressed in several structures, including brain ventricular layer; dorsal aorta; gonad; telencephalon; and trophectoderm. Orthologous to human AMOTL2 (angiomotin like 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in adrenal adult (RPKM 51.4), lung adult (RPKM 30.8) and 23 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F1; 9 54.71 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (102594290..102610616)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (102717091..102733418)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms.
Title: The VE-cadherin/AmotL2 mechanosensory pathway suppresses aortic inflammation and the formation of abdominal aortic aneurysms.
AMOTL2 restrains transforming growth factor-beta1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.
Title: AMOTL2 restrains transforming growth factor-β1-induced proliferation and extracellular matrix deposition of airway smooth muscle cells via the down-regulation of YAP1 activation.
mTORC2-mediated phosphorylation of AMOTL2 blocks its ability to inhibit YAP signaling.
Title: Phosphorylation of the Hippo Pathway Component AMOTL2 by the mTORC2 Kinase Promotes YAP Signaling, Resulting in Enhanced Glioblastoma Growth and Invasiveness.
AmotL2 disrupts apical-basal cell polarity and promotes tumor invasion.
Title: AmotL2 disrupts apical-basal cell polarity and promotes tumour invasion.
Amot, Amotl1, and Amotl2 are differentially expressed in uterine cells during the peri-implantation period.
Title: Differential expression of the motin family in the peri-implantation mouse uterus and their hormonal regulation.
Amotl2 plays a pivotal role in polarity, migration and proliferation of angiogenic endothelial cells
Title: Angiomotin-like2 gene (amotl2) is required for migration and proliferation of endothelial cells during angiogenesis.
Data show that MUPP1 interacts with angiomotin (Amot), JEAP/Amot-like 1 and MASCOT/Amot-like 2, and that all the Amot/JEAP family proteins also interacted with Patj, a close relative of MUPP1.
Title: Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126718 (e-PCR)
- UniSTS:208433

AW549739 (e-PCR)
- UniSTS:179961

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in endothelial cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of cell polarity involved in ameboidal cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in hippo signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within hippo signaling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in bicellular tight junction	IBA Inferred from Biological aspect of Ancestor more info
located_in bicellular tight junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in podosome	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: angiomotin-like protein 2

Names: Leman coiled-coil protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421298.1 → NP_001408227.1 angiomotin-like protein 2

Status: VALIDATED

Source sequence(s)

CT573150

UniProtKB/Swiss-Prot

B8JK80, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q8K371, Q9QUS0
NM_001421301.1 → NP_001408230.1 angiomotin-like protein 2

Status: VALIDATED

Source sequence(s)

CT573150

UniProtKB/Swiss-Prot

B8JK80, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q8K371, Q9QUS0

Related

ENSMUSP00000121113.2, ENSMUST00000153965.8
NM_019764.2 → NP_062738.2 angiomotin-like protein 2

See identical proteins and their annotated locations for NP_062738.2

Status: VALIDATED

Source sequence(s)

AK141348, BB726257

Consensus CDS

CCDS40745.1

UniProtKB/Swiss-Prot

B8JK80, Q3TPM1, Q7TPE4, Q8BP84, Q8BS08, Q8K371, Q9QUS0

UniProtKB/TrEMBL

B8JK87

Related

ENSMUSP00000035121.8, ENSMUST00000035121.14

Conserved Domains (2) summary

COG1196
Location:301 → 578

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12240
Location:478 → 679

Angiomotin_C; Angiomotin C terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

102594290..102610616

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511772.4 → XP_006511835.1 angiomotin-like protein 2 isoform X2

UniProtKB/TrEMBL

B8JK87

Conserved Domains (2) summary

COG1196
Location:324 → 601

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam12240
Location:501 → 702

Angiomotin_C; Angiomotin C terminal