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    Zfp106 zinc finger protein 106 [ Mus musculus (house mouse) ]

    Gene ID: 20402, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp106provided by MGI
    Official Full Name
    zinc finger protein 106provided by MGI
    Primary source
    MGI:MGI:1270153
    See related
    Ensembl:ENSMUSG00000027288 AllianceGenome:MGI:1270153
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    H3a; Cd-1; sirm; Sh3bp3; Znf106; D2Dcr28; zfp-106; EyeLinc12
    Summary
    Enables SH3 domain binding activity and opioid peptide activity. Acts upstream of or within insulin receptor signaling pathway. Located in cytosol and membrane. Is expressed in several structures, including adipose tissue; brain; esophagus; genitourinary system; and musculature. Used to study amyotrophic lateral sclerosis. Orthologous to human ZNF106 (zinc finger protein 106). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 47.5), frontal lobe adult (RPKM 16.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp106 in Genome Data Viewer
    Location:
    2 E5; 2 60.37 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (120337303..120394345, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (120506820..120563864, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene transmembrane protein 87A Neighboring gene STARR-positive B cell enhancer ABC_E10133 Neighboring gene STARR-positive B cell enhancer ABC_E9071 Neighboring gene glucosidase, alpha; neutral C Neighboring gene RIKEN cDNA 4931402G19 gene Neighboring gene STARR-seq mESC enhancer starr_05508 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120308865-120309066 Neighboring gene calpain 3 Neighboring gene STARR-seq mESC enhancer starr_05509 Neighboring gene STARR-seq mESC enhancer starr_05510 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120393240-120393349 Neighboring gene STARR-seq mESC enhancer starr_05511 Neighboring gene synaptosomal-associated protein 23 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:120435029-120435138 Neighboring gene STARR-seq mESC enhancer starr_05512 Neighboring gene leucine rich repeat containing 57 Neighboring gene HAUS augmin-like complex, subunit 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats. Celona B, et al. Proc Natl Acad Sci U S A, 2024 Jul 30. PMID 39042693,
    2. Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106. Celona B, et al. Elife, 2017 Jan 10. PMID 28072389, Free PMC Article
    3. End-targeting proteomics of isolated chromatin segments of a mammalian ribosomal RNA gene promoter. Ide S, et al. Nat Commun, 2015 Mar 27. PMID 25812914, Free PMC Article
    4. Subcellular recruitment by TSG118 and TSPYL implicates a role for zinc finger protein 106 in a novel developmental pathway. Grasberger H, et al. Int J Biochem Cell Biol, 2005 Jul. PMID 15833274
    5. Cell autonomous phosphoinositide 3-kinase activation in oocytes disrupts normal ovarian function through promoting survival and overgrowth of ovarian follicles. Kim SY, et al. Endocrinology, 2015 Apr. PMID 25594701, Free PMC Article

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.
      Title: Zfp106 binds to G-quadruplex RNAs and inhibits RAN translation and formation of RNA foci caused by G4C2 repeats.
    2. The authors identify the zinc finger protein Zfp106 as a specific GGGGCC RNA repeat-binding protein, and using affinity purification-mass spectrometry, they show that Zfp106 interacts with multiple other RNA binding proteins, including the amyotrophic lateral sclerosis-associated factors TDP-43 and FUS.
      Title: Suppression of C9orf72 RNA repeat-induced neurotoxicity by the ALS-associated RNA-binding protein Zfp106.
    3. Findings indicate a central role for Zfp106 in the maintenance of nerve-muscle signaling.
      Title: Severe muscle wasting and denervation in mice lacking the RNA-binding protein ZFP106.
    4. Zfp106-/- mice develop severe gait and motor abnormalities that deteriorate with age. The motor abnormalities exhibited by Zfp106-/- mice are likely due to a severe progressive adult-onset degenerative sensory-motor axonopathy.
      Title: Deficiency of the zinc finger protein ZFP106 causes motor and sensory neurodegeneration.
    5. ZFP106 is a novel factor regulating transcription initiation by targeting RNA polymerase I to the promoter.
      Title: End-targeting proteomics of isolated chromatin segments of a mammalian ribosomal RNA gene promoter.
    6. ZFP106 is a potential player in a novel pathway involved in testis development
      Title: Subcellular recruitment by TSG118 and TSPYL implicates a role for zinc finger protein 106 in a novel developmental pathway.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables SH3 domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables opioid peptide activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in insulin receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 106
    Names
    H3a minor histocompatibility antigen
    SH3-domain binding protein 3
    zinc finger protein 474

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001420972.1 → NP_001407901.1  zinc finger protein 106 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL772299

    2. NM_001420973.1 → NP_001407902.1  zinc finger protein 106 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL772299, AL935121
      Related
      ENSMUSP00000128995.2, ENSMUST00000171215.8

    3. NM_001420974.1 → NP_001407903.1  zinc finger protein 106 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL772299, AL935121

    4. NM_001420975.1 → NP_001407904.1  zinc finger protein 106 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL772299, AL935121

    5. NM_001420976.1 → NP_001407905.1  zinc finger protein 106 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL772299

    6. NM_001420977.1 → NP_001407906.1  zinc finger protein 106 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL772299

    7. NM_011743.4 → NP_035873.2  zinc finger protein 106 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL772299, AL935121
      Consensus CDS
      CCDS16621.1
      UniProtKB/Swiss-Prot
      A2AKH3, O55185, O88465, O88466, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3
      UniProtKB/TrEMBL
      R4GML0
      Related
      ENSMUSP00000055602.7, ENSMUST00000055241.13
      Conserved Domains (4) summary
      cd00200
      Location:1530 → 1807
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00020
      Location:7 → 29
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:530 → 681
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:1580 → 1619
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      120337303..120394345 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499042.5 → XP_006499105.1  zinc finger protein 106 isoform X2

      UniProtKB/Swiss-Prot
      A2AKH3, O55185, O88465, O88466, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3
      Conserved Domains (3) summary
      cd00200
      Location:1464 → 1741
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:464 → 615
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:1514 → 1553
      7WD40; WD40 repeat [structural motif]

    2. XM_030248878.2 → XP_030104738.1  zinc finger protein 106 isoform X1

      UniProtKB/Swiss-Prot
      A2AKH3, O55185, O88465, O88466, O88467, Q792M1, Q792P4, Q8CDZ8, Q8R3I4, Q9ESU3
      UniProtKB/TrEMBL
      R4GML0
      Conserved Domains (4) summary
      cd00200
      Location:1530 → 1807
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00020
      Location:7 → 29
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam05109
      Location:530 → 681
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:1580 → 1619
      7WD40; WD40 repeat [structural motif]

    3. XM_030248880.1 → XP_030104740.1  zinc finger protein 106 isoform X3

      Conserved Domains (2) summary
      cd00200
      Location:741 → 1018
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:791 → 830
      7WD40; WD40 repeat [structural motif]

    4. XM_036159870.1 → XP_036015763.1  zinc finger protein 106 isoform X4

      Conserved Domains (2) summary
      cd00200
      Location:314 → 591
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:364 → 403
      7WD40; WD40 repeat [structural motif]

    RNA

    1. XR_004939180.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_009165.1: Suppressed sequence

      Description
      NM_009165.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O88466.3 GenPept UniProtKB/Swiss-Prot:O88466

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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