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    AlaRS-m Alanyl-tRNA synthetase, mitochondrial [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38595, updated on 9-Dec-2024

    Summary

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    Official Symbol
    AlaRS-mprovided by FlyBase
    Official Full Name
    Alanyl-tRNA synthetase, mitochondrialprovided by FlyBase
    Primary source
    FLYBASE:FBgn0028962
    Locus tag
    Dmel_CG4633
    See related
    AllianceGenome:FB:FBgn0028962
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Aats-ala-m; AlaS; CG4633; Dm mt AlaRS; Dmel\CG4633
    Summary
    Predicted to enable alanine-tRNA ligase activity and aminoacyl-tRNA editing activity. Predicted to be involved in alanyl-tRNA aminoacylation. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in adult head; embryonic/larval midgut; and organism. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 8 and progressive leukoencephalopathy with ovarian failure. Orthologous to human AARS2 (alanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See AlaRS-m in Genome Data Viewer
    Location:
    64C7-64C7; 3-13 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5146098..5149852)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5139198..5142952)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45985 Neighboring gene Gdap1 Neighboring gene Fat storage inducing transmembrane protein Neighboring gene Signal recognition particle 54k Neighboring gene XPG-like endonuclease Neighboring gene alan shepard Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Positional recognition of a tRNA determinant dependent on a peptide insertion. Lovato MA, et al. Mol Cell, 2004 Mar 26. PMID 15053877
    2. Translocation within the acceptor helix of a major tRNA identity determinant. Lovato MA, et al. EMBO J, 2001 Sep 3. PMID 11532948, Free PMC Article
    3. The aminoacyl-tRNA synthetases of Drosophila melanogaster. Lu J, et al. Fly (Austin), 2015. PMID 26761199, Free PMC Article
    4. Towards comprehensive annotation of Drosophila melanogaster enzymes in FlyBase. Garapati PV, et al. Database (Oxford), 2019 Jan 1. PMID 30689844, Free PMC Article
    5. The SIN3 deacetylase complex represses genes encoding mitochondrial proteins: implications for the regulation of energy metabolism. Pile LA, et al. J Biol Chem, 2003 Sep 26. PMID 12865422

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alanine-tRNA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alanine-tRNA ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alanine-tRNA ligase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables aminoacyl-tRNA editing activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aminoacyl-tRNA editing activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in alanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in alanyl-tRNA aminoacylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in alanyl-tRNA aminoacylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Alanyl-tRNA synthetase, mitochondrial
    Names
    AlaRS-m-PA
    CG4633-PA
    mitochondrial alanyl-tRNA synthetase
    NP_523932.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5146098..5149852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079208.3 → NP_523932.2  Alanyl-tRNA synthetase, mitochondrial [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_523932.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U6B6, Q9VRJ1
      Related
      FBpp0076871
      Conserved Domains (4) summary
      smart00863
      Location:748 → 784
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
      PLN02900
      Location:13 → 1010
      PLN02900; alanyl-tRNA synthetase
      cd00673
      Location:14 → 261
      AlaRS_core; Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent formation of ...
      cl08469
      Location:570 → 667
      tRNA_SAD; Threonyl and Alanyl tRNA synthetase second additional domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRJ1.1 Q9VRJ1

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