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    Dnpep aspartyl aminopeptidase [ Mus musculus (house mouse) ]

    Gene ID: 13437, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Dnpepprovided by MGI
    Official Full Name
    aspartyl aminopeptidaseprovided by MGI
    Primary source
    MGI:MGI:1278328
    See related
    Ensembl:ENSMUSG00000026209 AllianceGenome:MGI:1278328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable identical protein binding activity. Predicted to be involved in proteolysis. Predicted to be located in cytosol. Orthologous to human DNPEP (aspartyl aminopeptidase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 135.2), large intestine adult (RPKM 105.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dnpep in Genome Data Viewer
    Location:
    1 C4; 1 38.71 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75285209..75294648, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75308565..75317654, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase receptor type N Neighboring gene regulated endocrine-specific protein 18 Neighboring gene VISTA enhancer mm1372 Neighboring gene desmin upstream regulatory region Neighboring gene predicted gene 15179 Neighboring gene desmin Neighboring gene SPEG complex locus

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Dietary fatty acid composition affects aminopeptidase activities in the testes of mice. Arechaga G, et al. Int J Androl, 2002 Apr. PMID 11903661
    2. DNPEP is not the only peptidase that produces SPAK fragments in kidney. Koumangoye R, et al. Physiol Rep, 2017 Nov. PMID 29122955, Free PMC Article
    3. Purification, characterization, and cloning of a cytosolic aspartyl aminopeptidase. Wilk S, et al. J Biol Chem, 1998 Jun 26. PMID 9632644
    4. Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling. Nakamura Y, et al. Mol Cell Biol, 2011 Jul. PMID 21576357, Free PMC Article
    5. Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones. Prashar P, et al. Dev Biol, 2014 May 15. PMID 24583261

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study shows that in the absence of aspartyl aminopeptidase (DNPEP), the kidney lysates retain their ability to cleave STE20/SPS1-related proline/alanine-rich kinase(SPAK), indicating that DNPEP might have been misidentified as the protease behind the kidney lysate activity, or that the aspartyl aminopeptidase might not be the only protease cleaving SPAK in kidney.
      Title: DNPEP is not the only peptidase that produces SPAK fragments in kidney.
    2. Results demonstrate that Mir140 is essential for normal endochondral bone development and suggest that the reduced BMP signaling caused by Dnpep upregulation plays a causal role in the skeletal defects of Mir140-null mice.
      Title: Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate bone morphogenetic protein signaling.
    3. dietary fatty acids affect activity in mouse testis
      Title: Dietary fatty acid composition affects aminopeptidase activities in the testes of mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables aminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    aspartyl aminopeptidase
    NP_001104301.1
    NP_001407066.1
    NP_001407067.1
    NP_001407068.1
    NP_001407069.1
    NP_001407070.1
    NP_001407071.1
    NP_001407072.1
    NP_001407073.1
    NP_001407074.1
    NP_001407075.1
    NP_058574.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001110831.2 → NP_001104301.1  aspartyl aminopeptidase isoform a

      See identical proteins and their annotated locations for NP_001104301.1

      Status: VALIDATED

      Source sequence(s)
      AC166150
      Consensus CDS
      CCDS78623.1
      UniProtKB/TrEMBL
      Q3TVK3, Q3U3I6, Q8CAJ7
      Related
      ENSMUSP00000140864.2, ENSMUST00000185797.7
      Conserved Domains (1) summary
      pfam02127
      Location:24 → 462
      Peptidase_M18; Aminopeptidase I zinc metalloprotease (M18)

    2. NM_001420137.1 → NP_001407066.1  aspartyl aminopeptidase isoform b

      Status: VALIDATED

      Source sequence(s)
      AC166150
      UniProtKB/Swiss-Prot
      Q56A00, Q9Z2W0

    3. NM_001420138.1 → NP_001407067.1  aspartyl aminopeptidase isoform b

      Status: VALIDATED

      Source sequence(s)
      AC166150
      UniProtKB/Swiss-Prot
      Q56A00, Q9Z2W0
      Related
      ENSMUSP00000070821.8, ENSMUST00000066668.14

    4. NM_001420139.1 → NP_001407068.1  aspartyl aminopeptidase isoform b

      Status: VALIDATED

      Source sequence(s)
      AC166150
      UniProtKB/Swiss-Prot
      Q56A00, Q9Z2W0
      Related
      ENSMUSP00000139739.2, ENSMUST00000187836.7

    5. NM_001420140.1 → NP_001407069.1  aspartyl aminopeptidase isoform b

      Status: VALIDATED

      Source sequence(s)
      AC166150
      UniProtKB/Swiss-Prot
      Q56A00, Q9Z2W0

    6. NM_001420141.1 → NP_001407070.1  aspartyl aminopeptidase isoform c

      Status: VALIDATED

      Source sequence(s)
      AC166150

    7. NM_001420142.1 → NP_001407071.1  aspartyl aminopeptidase isoform d

      Status: VALIDATED

      Source sequence(s)
      AC166150

    8. NM_001420143.1 → NP_001407072.1  aspartyl aminopeptidase isoform e

      Status: VALIDATED

      Source sequence(s)
      AC166150

    9. NM_001420144.1 → NP_001407073.1  aspartyl aminopeptidase isoform f

      Status: VALIDATED

      Source sequence(s)
      AC166150

    10. NM_001420145.1 → NP_001407074.1  aspartyl aminopeptidase isoform f

      Status: VALIDATED

      Source sequence(s)
      AC166150

    11. NM_001420146.1 → NP_001407075.1  aspartyl aminopeptidase isoform g

      Status: VALIDATED

      Source sequence(s)
      AC166150

    12. NM_016878.5 → NP_058574.3  aspartyl aminopeptidase isoform b

      See identical proteins and their annotated locations for NP_058574.3

      Status: VALIDATED

      Source sequence(s)
      AC166150
      Consensus CDS
      CCDS15070.1
      UniProtKB/Swiss-Prot
      Q56A00, Q9Z2W0
      UniProtKB/TrEMBL
      Q3U3I6, Q8CAJ7
      Related
      ENSMUSP00000109235.4, ENSMUST00000113605.10
      Conserved Domains (1) summary
      cd05658
      Location:16 → 461
      M18_DAP; M18 peptidase aspartyl aminopeptidase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75285209..75294648 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z2W0.2 GenPept UniProtKB/Swiss-Prot:Q9Z2W0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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