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    NFASC neurofascin [ Gallus gallus (chicken) ]

    Gene ID: 419824, updated on 10-Oct-2024

    Summary

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    Symbol
    NFASCprovided by CGNC
    Full Name
    neurofascinprovided by CGNC
    Primary source
    CGNC:51099
    See related
    Ensembl:ENSGALG00010027311
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Summary
    This gene encodes a member of the L1 subgroup of the immunoglobulin superfamily. Members of the L1 subgroup are associated with axons during development of the nervous system, and are characterized by the presence in the extracellular portion of the protein of six immunoglobulin-like domains and five fibronectin type III-like repeats. This gene undergoes extensive alternative splicing. Additional variants have been described but are of lower abundance. [provided by RefSeq, May 2009]
    Orthologs
    human mouse all
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    Genomic context

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    See NFASC in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 26 NC_052557.1 (1935801..2012617)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 26 NC_052598.1 (1906141..1982950)

    Chromosome 26 - NC_052557.1Genomic Context describing neighboring genes Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene MDM4, p53 regulator Neighboring gene leucine rich repeat neuronal 2 Neighboring gene uncharacterized LOC121107616 Neighboring gene contactin 2 Neighboring gene transmembrane protein 81 Neighboring gene RB binding protein 5, histone lysine methyltransferase complex subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A regulated switch of chick neurofascin isoforms modulates ligand recognition and neurite extension. Pruss T, et al. Mol Cell Neurosci, 2006 Feb. PMID 16314110
    2. Organization of the neurofascin gene and analysis of developmentally regulated alternative splicing. Hassel B, et al. J Biol Chem, 1997 Nov 7. PMID 9353344
    3. Structure of the axonal surface recognition molecule neurofascin and its relationship to a neural subgroup of the immunoglobulin superfamily. Volkmer H, et al. J Cell Biol, 1992 Jul. PMID 1377696, Free PMC Article
    4. The L1 family of neural cell adhesion molecules: old proteins performing new tricks. Hortsch M. Neuron, 1996 Oct. PMID 8893017
    5. Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin. Kirschbaum K, et al. J Biol Chem, 2009 Oct 16. PMID 19666467, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a neurofascin intracellular domain activates FGFR1 for neurite outgrowth, whereas the extracellular domain functions as an additional, regulatory FGFR1 interaction domain in the course of development
      Title: Analysis of non-canonical fibroblast growth factor receptor 1 (FGFR1) interaction reveals regulatory and activating domains of neurofascin.
    2. Results describe the roles of specific neurofascin isoforms in chick embryo dorsal root ganglion cells.
      Title: A regulated switch of chick neurofascin isoforms modulates ligand recognition and neurite extension.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables cell-cell adhesion mediator activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in brain development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    neurofascin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004493.5 → NP_001004493.1  neurofascin isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      JAENSK010000356
      UniProtKB/TrEMBL
      A0A8V1A3P6
      Related
      ENSGALP00010040505.1, ENSGALT00010066239.1
      Conserved Domains (9) summary
      cd00096
      Location:467 → 533
      Ig; Immunoglobulin domain
      cd05731
      Location:282 → 352
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:60 → 136
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:745 → 824
      FN3; Fibronectin type 3 domain
      smart00410
      Location:271 → 351
      IG_like; Immunoglobulin like
      cd00063
      Location:643 → 733
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:448 → 536
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1160 → 1248
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:369 → 444
      Ig; Immunoglobulin domain

    2. NM_001004709.5 → NP_001004709.2  neurofascin isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks four alternate in-frame exons compared to variant 2. The resulting protein (isoform 3) lacks three internal segments, compared to isoform 2. This variant is the most abundant variant in E16 embryos and includes alternatively spliced exons 3, 17, 26, and 27, as defined by Hassel et al (PMID: 9353344).
      Source sequence(s)
      JAENSK010000356
      UniProtKB/TrEMBL
      A0A8V1AB91
      Conserved Domains (9) summary
      cd00096
      Location:450 → 516
      Ig; Immunoglobulin domain
      cd05731
      Location:265 → 335
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:60 → 136
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:728 → 807
      FN3; Fibronectin type 3 domain
      smart00410
      Location:254 → 334
      IG_like; Immunoglobulin like
      cd00063
      Location:626 → 716
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:431 → 519
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1036 → 1120
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:352 → 427
      Ig; Immunoglobulin domain

    3. NM_001160320.4 → NP_001153792.1  neurofascin isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks five alternate in-frame exons compared to variant 2. The resulting protein (isoform 4) lacks four internal segments, compared to isoform 2. This variant is the 2nd most abundant variant in E16 embryos and includes alternatively spliced exons 8, 22, and 23, as defined by Hassel et al (PMID: 9353344).
      Source sequence(s)
      JAENSK010000356
      UniProtKB/TrEMBL
      A0A1D5PN99, A0A8V1A3P6
      Related
      ENSGALP00010040514.1, ENSGALT00010066248.1
      Conserved Domains (9) summary
      cd00096
      Location:461 → 527
      Ig; Immunoglobulin domain
      cd05731
      Location:276 → 346
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:54 → 130
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:727 → 806
      FN3; Fibronectin type 3 domain
      smart00410
      Location:265 → 345
      IG_like; Immunoglobulin like
      cd00063
      Location:625 → 715
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:442 → 530
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1062 → 1146
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:363 → 438
      Ig; Immunoglobulin domain

    4. NM_001160321.4 → NP_001153793.1  neurofascin isoform 5 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks five alternate in-frame exons compared to variant 2. The resulting protein (isoform 5) lacks four internal segments, compared to isoform 2. This variant is the 3rd most abundant variant in E16 embryos and includes alternatively spliced exons 3, 17, and 26, as defined by Hassel et al (PMID: 9353344).
      Source sequence(s)
      JAENSK010000356
      UniProtKB/TrEMBL
      A0A8V1AB91
      Conserved Domains (9) summary
      cd00096
      Location:450 → 516
      Ig; Immunoglobulin domain
      cd05731
      Location:265 → 335
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:60 → 136
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:728 → 807
      FN3; Fibronectin type 3 domain
      smart00410
      Location:254 → 334
      IG_like; Immunoglobulin like
      cd00063
      Location:626 → 716
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:431 → 519
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:961 → 1045
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:352 → 427
      Ig; Immunoglobulin domain

    5. NM_001160322.4 → NP_001153794.1  neurofascin isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks four alternate in-frame exons and includes two alternate in-frame exons, compared to variant 2. The resulting protein (isoform 6) lacks three internal segments and includes an additional segment, compared to isoform 2. This variant is the 4th most abundant variant in E16 embryos and includes alternatively spliced exons 3, 17, 26, 27, 28, and 29, as defined by Hassel et al (PMID: 9353344).
      Source sequence(s)
      JAENSK010000356
      UniProtKB/TrEMBL
      A0A8V1A8K6, A0A8V1AB91
      Related
      ENSGALP00010040507.1, ENSGALT00010066241.1
      Conserved Domains (9) summary
      cd05731
      Location:265 → 335
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:60 → 136
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00408
      Location:450 → 509
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:728 → 807
      FN3; Fibronectin type 3 domain
      smart00410
      Location:254 → 334
      IG_like; Immunoglobulin like
      cd00063
      Location:626 → 716
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:431 → 519
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1127 → 1211
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:352 → 427
      Ig; Immunoglobulin domain

    6. NM_001160323.4 → NP_001153795.1  neurofascin isoform 7 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks three alternate in-frame exons compared to variant 2. The resulting protein (isoform 7) lacks three internal segments, compared to isoform 2. This variant is the 5th most abundant variant in E16 embryos and includes alternatively spliced exons 8, 22, 23, 26, and 32, as defined by Hassel et al (PMID: 9353344).
      Source sequence(s)
      JAENSK010000356
      UniProtKB/TrEMBL
      A0A1D5P601, A0A8V1A3P6
      Related
      ENSGALP00010040512.1, ENSGALT00010066246.1
      Conserved Domains (9) summary
      cd00096
      Location:461 → 527
      Ig; Immunoglobulin domain
      cd05731
      Location:276 → 346
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:54 → 130
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:727 → 806
      FN3; Fibronectin type 3 domain
      smart00410
      Location:265 → 345
      IG_like; Immunoglobulin like
      cd00063
      Location:625 → 715
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:442 → 530
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1067 → 1155
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:363 → 438
      Ig; Immunoglobulin domain

    7. NM_001160324.4 → NP_001153796.1  neurofascin isoform 8 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks six alternate in-frame exons compared to variant 2. The resulting protein (isoform 8) lacks four internal segments, compared to isoform 2. This variant is the most abundant variant in E06 embryos and includes alternatively spliced exons 3 and 17, as defined by Hassel et al (PMID: 9353344).
      Source sequence(s)
      JAENSK010000356
      UniProtKB/TrEMBL
      A0A8V1AB91
      Conserved Domains (7) summary
      smart00060
      Location:728 → 807
      FN3; Fibronectin type 3 domain
      cd00063
      Location:626 → 716
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam13882
      Location:956 → 1036
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:355 → 359
      Ig; Ig strand B [structural motif]
      cd05731
      Location:253 → 335
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05875
      Location:42 → 136
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:339 → 427
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052557.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      1935801..2012617
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040652705.2 → XP_040508639.1  neurofascin isoform X14

      UniProtKB/TrEMBL
      A0A8V1AB91
      Conserved Domains (7) summary
      smart00060
      Location:728 → 807
      FN3; Fibronectin type 3 domain
      cd00063
      Location:626 → 716
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam13882
      Location:956 → 1036
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:355 → 359
      Ig; Ig strand B [structural motif]
      cd05731
      Location:253 → 335
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05875
      Location:42 → 136
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:339 → 427
      Ig; Immunoglobulin domain

    2. XM_040652711.2 → XP_040508645.1  neurofascin isoform X19

      Conserved Domains (6) summary
      smart00060
      Location:728 → 807
      FN3; Fibronectin type 3 domain
      smart00409
      Location:254 → 334
      IG; Immunoglobulin
      smart00410
      Location:529 → 610
      IG_like; Immunoglobulin like
      cd00063
      Location:626 → 716
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:346 → 350
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:340 → 426
      Ig; Immunoglobulin domain

    3. XM_015298903.4 → XP_015154389.1  neurofascin isoform X1

      UniProtKB/Swiss-Prot
      O42414, Q90924
      Conserved Domains (7) summary
      smart00060
      Location:745 → 824
      FN3; Fibronectin type 3 domain
      cd00063
      Location:643 → 733
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam13882
      Location:1251 → 1335
      Bravo_FIGEY; Bravo-like intracellular region
      cd00096
      Location:372 → 376
      Ig; Ig strand B [structural motif]
      cd05731
      Location:270 → 352
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM), and similar domains
      cd05875
      Location:42 → 136
      IgI_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF); member of the I-set of Ig superfamily (IgSF) domains
      cl11960
      Location:356 → 444
      Ig; Immunoglobulin domain

    4. XM_015298906.4 → XP_015154392.1  neurofascin isoform X2

      UniProtKB/Swiss-Prot
      O42414, Q90924
      Related
      ENSGALP00010040496.1, ENSGALT00010066230.1
      Conserved Domains (9) summary
      cd05731
      Location:282 → 352
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:60 → 136
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00408
      Location:467 → 526
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:745 → 824
      FN3; Fibronectin type 3 domain
      smart00410
      Location:271 → 351
      IG_like; Immunoglobulin like
      cd00063
      Location:643 → 733
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:448 → 536
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1251 → 1335
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:369 → 444
      Ig; Immunoglobulin domain

    5. XM_025143685.3 → XP_024999453.1  neurofascin isoform X3

      UniProtKB/TrEMBL
      A0A8V1A3P6
      Conserved Domains (7) summary
      cd05875
      Location:60 → 136
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:745 → 824
      FN3; Fibronectin type 3 domain
      cd00063
      Location:643 → 733
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam13882
      Location:1160 → 1244
      Bravo_FIGEY; Bravo-like intracellular region
      cd05731
      Location:282 → 352
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cl11960
      Location:369 → 444
      Ig; Immunoglobulin domain
      cl28434
      Location:448 → 536
      I-set; Immunoglobulin I-set domain

    6. XM_015298913.4 → XP_015154399.1  neurofascin isoform X4

      UniProtKB/TrEMBL
      A0A8V1A3P6
      Conserved Domains (9) summary
      cd00096
      Location:467 → 533
      Ig; Immunoglobulin domain
      cd05731
      Location:282 → 352
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:60 → 136
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:745 → 824
      FN3; Fibronectin type 3 domain
      smart00410
      Location:271 → 351
      IG_like; Immunoglobulin like
      cd00063
      Location:643 → 733
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:448 → 536
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1085 → 1173
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:369 → 444
      Ig; Immunoglobulin domain

    7. XM_046904109.1 → XP_046760065.1  neurofascin isoform X5

    8. XM_015298914.4 → XP_015154400.1  neurofascin isoform X6

      UniProtKB/TrEMBL
      A0A8V1A3P6
      Conserved Domains (9) summary
      cd00096
      Location:467 → 533
      Ig; Immunoglobulin domain
      cd05731
      Location:282 → 352
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:60 → 136
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:745 → 824
      FN3; Fibronectin type 3 domain
      smart00410
      Location:271 → 351
      IG_like; Immunoglobulin like
      cd00063
      Location:643 → 733
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:448 → 536
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1080 → 1168
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:369 → 444
      Ig; Immunoglobulin domain

    9. XM_025143686.3 → XP_024999454.1  neurofascin isoform X7

      UniProtKB/TrEMBL
      A0A8V1A3P6
      Conserved Domains (7) summary
      cd05875
      Location:60 → 136
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:745 → 824
      FN3; Fibronectin type 3 domain
      cd00063
      Location:643 → 733
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam13882
      Location:1080 → 1164
      Bravo_FIGEY; Bravo-like intracellular region
      cd05731
      Location:282 → 352
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cl11960
      Location:369 → 444
      Ig; Immunoglobulin domain
      cl28434
      Location:448 → 536
      I-set; Immunoglobulin I-set domain

    10. XM_015298918.4 → XP_015154404.1  neurofascin isoform X12

      UniProtKB/TrEMBL
      A0A8V1A3P6, A0A8V1A8L6
      Related
      ENSGALP00010040517.1, ENSGALT00010066251.1
      Conserved Domains (9) summary
      cd00096
      Location:467 → 533
      Ig; Immunoglobulin domain
      cd05731
      Location:282 → 352
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:60 → 136
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:745 → 824
      FN3; Fibronectin type 3 domain
      smart00410
      Location:271 → 351
      IG_like; Immunoglobulin like
      cd00063
      Location:643 → 733
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:448 → 536
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:973 → 1057
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:369 → 444
      Ig; Immunoglobulin domain

    11. XM_015298919.4 → XP_015154405.1  neurofascin isoform X17

      Conserved Domains (9) summary
      cd00096
      Location:467 → 533
      Ig; Immunoglobulin domain
      cd05731
      Location:282 → 352
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:60 → 136
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:745 → 824
      FN3; Fibronectin type 3 domain
      smart00410
      Location:271 → 351
      IG_like; Immunoglobulin like
      cd00063
      Location:643 → 733
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:448 → 536
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:874 → 958
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:369 → 444
      Ig; Immunoglobulin domain

    12. XM_025143688.3 → XP_024999456.1  neurofascin isoform X9

      UniProtKB/TrEMBL
      A0A8V1A3P6
      Conserved Domains (7) summary
      cd05875
      Location:60 → 136
      Ig_hNeurofascin_like; Immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:733 → 812
      FN3; Fibronectin type 3 domain
      cd00063
      Location:631 → 721
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam13882
      Location:1068 → 1156
      Bravo_FIGEY; Bravo-like intracellular region
      cd05731
      Location:282 → 352
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cl11960
      Location:369 → 444
      Ig; Immunoglobulin domain
      cl28434
      Location:448 → 536
      I-set; Immunoglobulin I-set domain

    13. XM_015298920.4 → XP_015154406.1  neurofascin isoform X21

      UniProtKB/Swiss-Prot
      O42414, Q90924
      Conserved Domains (9) summary
      cd05731
      Location:265 → 335
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:60 → 136
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00408
      Location:450 → 509
      IGc2; Immunoglobulin C-2 Type
      smart00060
      Location:728 → 807
      FN3; Fibronectin type 3 domain
      smart00410
      Location:254 → 334
      IG_like; Immunoglobulin like
      cd00063
      Location:626 → 716
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:431 → 519
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1234 → 1318
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:352 → 427
      Ig; Immunoglobulin domain

    14. XM_040652710.2 → XP_040508644.1  neurofascin isoform X19

      Conserved Domains (6) summary
      smart00060
      Location:728 → 807
      FN3; Fibronectin type 3 domain
      smart00409
      Location:254 → 334
      IG; Immunoglobulin
      smart00410
      Location:529 → 610
      IG_like; Immunoglobulin like
      cd00063
      Location:626 → 716
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:346 → 350
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:340 → 426
      Ig; Immunoglobulin domain

    15. XM_015298915.4 → XP_015154401.1  neurofascin isoform X8

      UniProtKB/TrEMBL
      A0A8V1A3P6
      Conserved Domains (9) summary
      cd00096
      Location:461 → 527
      Ig; Immunoglobulin domain
      cd05731
      Location:276 → 346
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:54 → 130
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:739 → 818
      FN3; Fibronectin type 3 domain
      smart00410
      Location:265 → 345
      IG_like; Immunoglobulin like
      cd00063
      Location:637 → 727
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:442 → 530
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1079 → 1163
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:363 → 438
      Ig; Immunoglobulin domain

    16. XM_040652703.2 → XP_040508637.1  neurofascin isoform X13

      UniProtKB/TrEMBL
      A0A8V1A3P6, A0A8V1ADZ4
      Related
      ENSGALP00010040493.1, ENSGALT00010066227.1
      Conserved Domains (6) summary
      smart00060
      Location:739 → 818
      FN3; Fibronectin type 3 domain
      smart00409
      Location:265 → 345
      IG; Immunoglobulin
      smart00410
      Location:144 → 228
      IG_like; Immunoglobulin like
      cd00063
      Location:637 → 727
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:357 → 361
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:351 → 437
      Ig; Immunoglobulin domain

    17. XM_040652709.2 → XP_040508643.1  neurofascin isoform X18

      Conserved Domains (6) summary
      smart00060
      Location:739 → 818
      FN3; Fibronectin type 3 domain
      smart00409
      Location:265 → 345
      IG; Immunoglobulin
      smart00410
      Location:540 → 621
      IG_like; Immunoglobulin like
      cd00063
      Location:637 → 727
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:357 → 361
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:351 → 437
      Ig; Immunoglobulin domain

    18. XM_015298916.4 → XP_015154402.1  neurofascin isoform X10

      UniProtKB/TrEMBL
      A0A8V1A3P6
      Conserved Domains (9) summary
      cd00096
      Location:461 → 527
      Ig; Immunoglobulin domain
      cd05731
      Location:276 → 346
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:54 → 130
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:727 → 806
      FN3; Fibronectin type 3 domain
      smart00410
      Location:265 → 345
      IG_like; Immunoglobulin like
      cd00063
      Location:625 → 715
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:442 → 530
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1067 → 1151
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:363 → 438
      Ig; Immunoglobulin domain

    19. XM_040652706.2 → XP_040508640.1  neurofascin isoform X15

      UniProtKB/TrEMBL
      A0A8V1AB91
      Conserved Domains (6) summary
      smart00060
      Location:727 → 806
      FN3; Fibronectin type 3 domain
      smart00409
      Location:265 → 345
      IG; Immunoglobulin
      smart00410
      Location:144 → 228
      IG_like; Immunoglobulin like
      cd00063
      Location:625 → 715
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:366 → 370
      Ig; Ig strand B [structural motif]
      cl11960
      Location:351 → 437
      Ig; Immunoglobulin domain

    20. XM_040652707.2 → XP_040508641.1  neurofascin isoform X16

      UniProtKB/TrEMBL
      A0A8V1AB91
      Conserved Domains (6) summary
      smart00060
      Location:722 → 801
      FN3; Fibronectin type 3 domain
      smart00409
      Location:248 → 328
      IG; Immunoglobulin
      smart00410
      Location:523 → 604
      IG_like; Immunoglobulin like
      cd00063
      Location:620 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:340 → 344
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:334 → 420
      Ig; Immunoglobulin domain

    21. XM_040652712.2 → XP_040508646.1  neurofascin isoform X20

      Conserved Domains (6) summary
      smart00060
      Location:722 → 801
      FN3; Fibronectin type 3 domain
      smart00409
      Location:248 → 328
      IG; Immunoglobulin
      smart00410
      Location:523 → 604
      IG_like; Immunoglobulin like
      cd00063
      Location:620 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:340 → 344
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:334 → 420
      Ig; Immunoglobulin domain

    22. XM_015298917.4 → XP_015154403.1  neurofascin isoform X11

      UniProtKB/TrEMBL
      A0A8V1A3P6
      Conserved Domains (9) summary
      cd00096
      Location:444 → 510
      Ig; Immunoglobulin domain
      cd05731
      Location:259 → 329
      Ig3_L1-CAM_like; Third immunoglobulin (Ig)-like domain of the L1 cell adhesion molecule (CAM)
      cd05875
      Location:54 → 130
      Ig6_hNeurofascin_like; Sixth immunoglobulin (Ig)-like domain of human neurofascin (NF)
      smart00060
      Location:710 → 789
      FN3; Fibronectin type 3 domain
      smart00410
      Location:248 → 328
      IG_like; Immunoglobulin like
      cd00063
      Location:608 → 698
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam07679
      Location:425 → 513
      I-set; Immunoglobulin I-set domain
      pfam13882
      Location:1050 → 1134
      Bravo_FIGEY; Bravo-like intracellular region
      cl11960
      Location:346 → 421
      Ig; Immunoglobulin domain

    23. XM_040652708.2 → XP_040508642.1  neurofascin isoform X16

      UniProtKB/TrEMBL
      A0A8V1AB91
      Conserved Domains (6) summary
      smart00060
      Location:722 → 801
      FN3; Fibronectin type 3 domain
      smart00409
      Location:248 → 328
      IG; Immunoglobulin
      smart00410
      Location:523 → 604
      IG_like; Immunoglobulin like
      cd00063
      Location:620 → 710
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      cd00096
      Location:340 → 344
      Ig; Ig strand A' [structural motif]
      cl11960
      Location:334 → 420
      Ig; Immunoglobulin domain

    RNA

    1. XR_005841860.2 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052598.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      1906141..1982950
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046932920.1 → XP_046788876.1  neurofascin isoform X14

    2. XM_046932927.1 → XP_046788883.1  neurofascin isoform X19

    3. XM_046932907.1 → XP_046788863.1  neurofascin isoform X1

    4. XM_046932908.1 → XP_046788864.1  neurofascin isoform X2

    5. XM_046932909.1 → XP_046788865.1  neurofascin isoform X3

    6. XM_046932910.1 → XP_046788866.1  neurofascin isoform X4

    7. XM_046932911.1 → XP_046788867.1  neurofascin isoform X5

    8. XM_046932912.1 → XP_046788868.1  neurofascin isoform X6

    9. XM_046932913.1 → XP_046788869.1  neurofascin isoform X7

    10. XM_046932918.1 → XP_046788874.1  neurofascin isoform X12

      UniProtKB/TrEMBL
      A0A8V1A8L6

    11. XM_046932924.1 → XP_046788880.1  neurofascin isoform X17

    12. XM_046932915.1 → XP_046788871.1  neurofascin isoform X9

    13. XM_046932929.1 → XP_046788885.1  neurofascin isoform X21

    14. XM_046932926.1 → XP_046788882.1  neurofascin isoform X19

    15. XM_046932914.1 → XP_046788870.1  neurofascin isoform X8

    16. XM_046932919.1 → XP_046788875.1  neurofascin isoform X13

      UniProtKB/TrEMBL
      A0A8V1ADZ4

    17. XM_046932925.1 → XP_046788881.1  neurofascin isoform X18

    18. XM_046932916.1 → XP_046788872.1  neurofascin isoform X10

    19. XM_046932921.1 → XP_046788877.1  neurofascin isoform X15

    20. XM_046932922.1 → XP_046788878.1  neurofascin isoform X16

    21. XM_046932928.1 → XP_046788884.1  neurofascin isoform X20

    22. XM_046932917.1 → XP_046788873.1  neurofascin isoform X11

    23. XM_046932923.1 → XP_046788879.1  neurofascin isoform X16

    RNA

    1. XR_006937134.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001004394.2: Suppressed sequence

      Description
      NM_001004394.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O42414.1 GenPept UniProtKB/Swiss-Prot:O42414

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials