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    CG4042 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40291, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG4042provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037018
    Locus tag
    Dmel_CG4042
    See related
    AllianceGenome:FB:FBgn0037018
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    dATP5SL; Dmel\CG4042
    Summary
    Predicted to be involved in mitochondrial respiratory chain complex I assembly. Is active in mitochondrion. Is expressed in several structures, including adult head; embryonic/larval midgut; embryonic/larval midgut primordium; and larval muscle cell. Orthologous to human DMAC2 (distal membrane arm assembly component 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG4042 in Genome Data Viewer
    Location:
    77E6-77E6; 3-47 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (20770143..20771507, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (20763243..20764607, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene pitslre Neighboring gene Peroxin 16 Neighboring gene Peroxin 14 Neighboring gene Phosphorylated CTD-interacting factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis. Murari A, et al. iScience, 2021 Aug 20. PMID 34386730, Free PMC Article
    2. In vivo analysis of proteomes and interactomes using Parallel Affinity Capture (iPAC) coupled to mass spectrometry. Rees JS, et al. Mol Cell Proteomics, 2011 Jun. PMID 21447707, Free PMC Article
    3. Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution. Leung W, et al. G3 (Bethesda), 2015 Mar 4. PMID 25740935, Free PMC Article
    4. Putative synaptic genes defined from a Drosophila whole body developmental transcriptome by a machine learning approach. Pazos Obregón F, et al. BMC Genomics, 2015 Sep 15. PMID 26370122, Free PMC Article
    5. Protein interaction mapping: a Drosophila case study. Formstecher E, et al. Genome Res, 2005 Mar. PMID 15710747, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex I assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG4042-PA
    CG4042-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      20770143..20771507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001275192.1 → NP_001262121.1  uncharacterized protein Dmel_CG4042, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262121.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYK3, Q9VPC1
      Conserved Domains (1) summary
      sd00034
      Location:192 → 221
      LRR_AMN1; leucine-rich repeat [structural motif]

    2. NM_140993.4 → NP_649250.2  uncharacterized protein Dmel_CG4042, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649250.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8SYK3, Q9VPC1
      Related
      FBpp0077937
      Conserved Domains (1) summary
      sd00034
      Location:192 → 221
      LRR_AMN1; leucine-rich repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8SYK3 Q8SYK3
    Q9VPC1 Q9VPC1

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