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    rogdi rogdi [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39917, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rogdiprovided by FlyBase
    Official Full Name
    rogdiprovided by FlyBase
    Primary source
    FLYBASE:FBgn0036697
    Locus tag
    Dmel_CG7725
    See related
    AllianceGenome:FB:FBgn0036697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG7725; Dmel\CG7725; Rogdi
    Summary
    Involved in behavioral response to ethanol; gamma-aminobutyric acid secretion, neurotransmission; and sleep. Predicted to be part of RAVE complex. Is expressed in adult head; organism; and yolk nucleus. Human ortholog(s) of this gene implicated in Kohlschutter-Tonz syndrome. Orthologous to human ROGDI (rogdi atypical leucine zipper). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rogdi in Genome Data Viewer
    Location:
    73E5-73E5; 3-45 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (17049512..17055454)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (17042612..17048554)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene PAPS transporter 2 Neighboring gene Troponin C at 73F Neighboring gene POP5 ribonuclease P/MRP subunit Neighboring gene uncharacterized protein Neighboring gene RNA-binding protein 6 Neighboring gene antisense RNA:CR43433

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rogdi Defines GABAergic Control of a Wake-promoting Dopaminergic Pathway to Sustain Sleep in Drosophila. Kim M, et al. Sci Rep, 2017 Sep 12. PMID 28900300, Free PMC Article
    2. Metabolic flux from the Krebs cycle to glutamate transmission tunes a neural brake on seizure onset. Jeong J, et al. PLoS Genet, 2021 Oct. PMID 34714823, Free PMC Article
    3. Shared visual attention and memory systems in the Drosophila brain. van Swinderen B, et al. PLoS One, 2009 Jun 19. PMID 19543525, Free PMC Article
    4. Waking experience affects sleep need in Drosophila. Ganguly-Fitzgerald I, et al. Science, 2006 Sep 22. PMID 16990546
    5. Ethanol sensitivity and tolerance in long-term memory mutants of Drosophila melanogaster. Berger KH, et al. Alcohol Clin Exp Res, 2008 May. PMID 18435628, Free PMC Article

    See all (36) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in behavioral response to ethanol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gamma-aminobutyric acid secretion, neurotransmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sleep IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of RAVE complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rogdi
    Names
    CG7725-PA
    CG7725-PB
    rogdi-PA
    rogdi-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      17049512..17055454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_168717.2 → NP_730244.1  rogdi, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730244.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9VVE2
      Related
      FBpp0075042
      Conserved Domains (1) summary
      pfam10259
      Location:93 → 280
      Rogdi_lz; Rogdi leucine zipper containing protein

    2. NM_140699.3 → NP_648956.1  rogdi, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648956.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q32KF2, Q8IQP4, Q95T16, Q9VVE2
      Related
      FBpp0075043
      Conserved Domains (1) summary
      pfam10259
      Location:18 → 205
      Rogdi_lz; Rogdi leucine zipper containing protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VVE2.2 Q9VVE2

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