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    GluRIB Glutamate receptor IB [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44484, updated on 17-Dec-2024

    Summary

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    Official Symbol
    GluRIBprovided by FlyBase
    Official Full Name
    Glutamate receptor IBprovided by FlyBase
    Primary source
    FLYBASE:FBgn0264000
    Locus tag
    Dmel_CG43743
    See related
    AllianceGenome:FB:FBgn0264000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG42509; CG43743; CG4481; dglur-IB; DGluR-IB; DmelGlu-R1B; Dmel\CG43743; Dm_3L:43677; Glu-R1B; Glu-RIB; GluR1B; GluRIb
    Old locus tag
    Dmel_CG42509; Dmel_CG4481
    Summary
    Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission; modulation of chemical synaptic transmission; and monoatomic cation transport. Predicted to be located in membrane. Predicted to be part of ionotropic glutamate receptor complex. Predicted to be active in postsynaptic density membrane. Is expressed in adult brain; adult head; and larval central nervous system. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal recessive intellectual developmental disorder 76; epilepsy; schizophrenia; and syndromic X-linked intellectual disability 94. Orthologous to several human genes including GRIA2 (glutamate ionotropic receptor AMPA type subunit 2) and GRIA3 (glutamate ionotropic receptor AMPA type subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GluRIB in Genome Data Viewer
    Location:
    67A4-67A6; 3-28 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9251978..9288522)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9245078..9281622)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Peptidoglycan recognition protein LA Neighboring gene Peptidoglycan recognition protein LC

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Comparison of ultra-conserved elements in drosophilids and vertebrates. Makunin IV, et al. PLoS One, 2013. PMID 24349264, Free PMC Article
    2. Glutamate Is a Wake-Active Neurotransmitter in Drosophila melanogaster. Zimmerman JE, et al. Sleep, 2017 Feb 1. PMID 28364503, Free PMC Article
    3. Novel CNS glutamate receptor subunit genes of Drosophila melanogaster. Völkner M, et al. J Neurochem, 2000 Nov. PMID 11032867
    4. Gene duplication in the major insecticide target site, Rdl, in Drosophila melanogaster. Remnant EJ, et al. Proc Natl Acad Sci U S A, 2013 Sep 3. PMID 23959864, Free PMC Article
    5. Chromatin gene-gene loops support the cross-regulation of genes with related function. Pollex T, et al. Mol Cell, 2024 Mar 7. PMID 38157845

    See all (59) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables extracellular ligand-gated monoatomic ion channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic cation transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of ionotropic glutamate receptor complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor IB
    Names
    CG43743-PA
    CG43743-PB
    CG43743-PC
    CG43743-PD
    GluRIB-PA
    GluRIB-PB
    GluRIB-PC
    GluRIB-PD
    glutamate receptor

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      9251978..9288522
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274693.1 → NP_001261622.1  glutamate receptor IB, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TVG7, Q9VSV5
      Conserved Domains (4) summary
      cd06380
      Location:43 → 478
      PBP1_iGluR_AMPA; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor
      cd13715
      Location:497 → 938
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:632 → 967
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:55 → 461
      ANF_receptor; Receptor family ligand binding region

    2. NM_080016.4 → NP_524755.2  glutamate receptor IB, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524755.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TVG7, Q9VSV5
      Related
      FBpp0303372
      Conserved Domains (4) summary
      cd06380
      Location:43 → 478
      PBP1_iGluR_AMPA; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor
      cd13715
      Location:497 → 938
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:632 → 967
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:55 → 461
      ANF_receptor; Receptor family ligand binding region

    3. NM_001274692.1 → NP_001261621.2  glutamate receptor IB, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261621.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHV5, Q9TVG7
      Conserved Domains (4) summary
      cd06380
      Location:43 → 478
      PBP1_iGluR_AMPA; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor
      cd13715
      Location:497 → 938
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:632 → 967
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:55 → 461
      ANF_receptor; Receptor family ligand binding region

    4. NM_001316480.1 → NP_001303409.1  glutamate receptor IB, isoform D [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0S0WIE7, Q9TVG7
      Conserved Domains (4) summary
      cd06380
      Location:43 → 478
      PBP1_iGluR_AMPA; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the AMPA receptor
      cd13715
      Location:497 → 938
      PBP2_iGluR_AMPA; The ligand-binding domain of the AMPA (alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid) subtypes of ionotropic glutamate receptors, a member of the type 2 periplasmic binding fold protein superfamily
      pfam00060
      Location:632 → 967
      Lig_chan; Ligand-gated ion channel
      pfam01094
      Location:55 → 461
      ANF_receptor; Receptor family ligand binding region
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0S0WIE7 A0A0S0WIE7
    M9PHV5 M9PHV5
    Q9TVG7 Q9TVG7
    Q9VSV5 Q9VSV5

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