orb2 orb2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: orb2provided by FlyBase
Official Full Name: orb2provided by FlyBase
Primary source: FLYBASE:FBgn0264307
Locus tag: Dmel_CG43782
See related: AllianceGenome:FB:FBgn0264307
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0140519.222; CG43113; CG43782; cg5735; CG5735; Dmel\CG43782; Orb2; Orb2A; Orb2B
Old locus tag: Dmel_CG43113; Dmel_CG5735; Dmel_CG5741
Summary: Enables identical protein binding activity; mRNA 3'-UTR binding activity; and translation regulator activity, nucleic acid binding. Involved in several processes, including long-term memory; regulation of translation; and spermatid development. Located in several cellular components, including dendrite terminus; perinuclear region of cytoplasm; and synaptic membrane. Part of protein-containing complex. Is active in postsynapse and presynapse. Is expressed in several structures, including central nervous system; ganglia; germline cell; gonad; and synaptic neuropil domain. Orthologous to several human genes including CPEB2 (cytoplasmic polyadenylation element binding protein 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 66E4-66E5; 3-27 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (8937100..8954463, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (8930200..8947563, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation.
Title: Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation.
Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.
Title: Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.
Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like beta-sheets.
Title: Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like β-sheets.
The 3'UTR of the Drosophila CPEB translation factor gene orb2 plays a crucial role in spermatogenesis.
Title: The 3'UTR of the Drosophila CPEB translation factor gene orb2 plays a crucial role in spermatogenesis.
Droplet and fibril formation of the functional amyloid Orb2.
Title: Droplet and fibril formation of the functional amyloid Orb2.
Implications of the Orb2 Amyloid Structure in Huntington's Disease.
Title: Implications of the Orb2 Amyloid Structure in Huntington's Disease.
We present here evidences of a novel genetic mechanism to regulate synapse fine tuning during development and propose an equilibrium between Orb2 conformational state and nervous system formation.
Title: Orb2 as modulator of Brat and their role at the neuromuscular junction.
The N-terminus of Orb2A not only promotes the formation of fibrils, but also forms the fibril core.
Title: Identification and Structural Characterization of the N-terminal Amyloid Core of Orb2 isoform A.
Data confirm the original hypothesis that the glutamine, histidine-rich (Q/H-rich) domain of Orb2 can bind to transition metals via its His residues. Hence, the Q/H rich domain behaves like other H-rich domains, most of which were shown to be metal binding domains.
Title: Metal Binding Properties of the N-Terminus of the Functional Amyloid Orb2.
Study showed that the N-terminus specific to Orb2A can bind to lipid membranes; binding occurs preferentially to curved membranes and requires the membranes to be negatively charged. When binding to lipid membranes, the N-terminus of Orb2A undergoes a transition from a dynamic, intrinsically disordered state to a less dynamic alpha-helix. This lipid membrane interaction can prevent the N-terminus from forming amyloid f...
Title: The Functional Amyloid Orb2A Binds to Lipid Membranes.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables RNA binding	ISM Inferred from Sequence Model more info	PubMed
enables RNA binding	NAS Non-traceable Author Statement more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA regulatory element binding translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA regulatory element binding translation repressor activity	IDA Inferred from Direct Assay more info	PubMed
enables mRNA regulatory element binding translation repressor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables translation factor activity, RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in asymmetric cell division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in long-term memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male courtship behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of translation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in sperm axoneme assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in cell body	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	HDA more info	PubMed
located_in dendrite terminus	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynapse	IMP Inferred from Mutant Phenotype more info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: orb2

Names: CG43782-PA; CG43782-PB; CG43782-PC; CG43782-PD; CG43782-PH; CG43782-PJ; CG43782-PK; cg43782 gene product from transcript cg43782-rh; orb2-PA; orb2-PB; orb2-PC; orb2-PD; orb2-PH; orb2-PJ; orb2-PK

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

8937100..8954463 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_140009.3 → NP_648266.1 orb2, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648266.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95T31, Q9VSR2, Q9VSR3

UniProtKB/TrEMBL

A4V1P2

Conserved Domains (4) summary

COG0724
Location:446 → 509

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:447 → 538

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:555 → 635

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:630 → 691

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_001274679.1 → NP_001261608.1 orb2, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001261608.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95T31, Q9VSR2, Q9VSR3

UniProtKB/TrEMBL

A4V1P2

Conserved Domains (4) summary

COG0724
Location:446 → 509

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:447 → 538

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:555 → 635

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:630 → 691

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_001370022.1 → NP_001356977.1 orb2, isoform J [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4D6K616

Conserved Domains (3) summary

cd12724
Location:447 → 538

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:555 → 635

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:630 → 691

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_001370023.1 → NP_001356978.1 orb2, isoform K [Drosophila melanogaster]

Status: REVIEWED

UniProtKB/TrEMBL

A0A4D6K784

Conserved Domains (3) summary

cd12724
Location:447 → 538

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:555 → 635

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:630 → 691

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_168300.3 → NP_729427.1 orb2, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729427.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95T31, Q9VSR2, Q9VSR3

UniProtKB/TrEMBL

A4V1P2

Conserved Domains (4) summary

COG0724
Location:446 → 509

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:447 → 538

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:555 → 635

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:630 → 691

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_168301.3 → NP_729428.1 orb2, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729428.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q95T31, Q9VSR2, Q9VSR3

UniProtKB/TrEMBL

A4V1P2

Conserved Domains (4) summary

COG0724
Location:446 → 509

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:447 → 538

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:555 → 635

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:630 → 691

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_168302.3 → NP_729429.1 orb2, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729429.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9VSR3

Conserved Domains (4) summary

COG0724
Location:293 → 356

RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

cd12724
Location:294 → 385

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:402 → 482

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:477 → 538

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain