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    Mtmr6 Myotubularin related protein 6 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37707, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtmr6provided by FlyBase
    Official Full Name
    Myotubularin related protein 6provided by FlyBase
    Primary source
    FLYBASE:FBgn0028497
    Locus tag
    Dmel_CG3530
    See related
    AllianceGenome:FB:FBgn0028497
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA; BcDNA:GH04637; CG18093; CG3530; Dmel\CG3530; Dmtm-6; Dmtm6; dMtmr6; MTMR6/7/8
    Summary
    Predicted to enable phosphatidylinositol-3,5-bisphosphate phosphatase activity and phosphatidylinositol-3-phosphate phosphatase activity. Involved in mitotic cell cycle and regulation of macroautophagy. Predicted to be active in cytoplasm. Is expressed in adult head and organism. Orthologous to human MTMR6 (myotubularin related protein 6); MTMR7 (myotubularin related protein 7); and MTMR8 (myotubularin related protein 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Mtmr6 in Genome Data Viewer
    Location:
    59D10-59D10; 2-102 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23389009..23396680, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19276532..19284203, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44784 Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 2B subunit delta Neighboring gene reduction of Rh1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Myotubularin phosphatases: policing 3-phosphoinositides. Robinson FL, et al. Trends Cell Biol, 2006 Aug. PMID 16828287
    2. Condition-dependent functional shift of two Drosophila Mtmr lipid phosphatases in autophagy control. Manzéger A, et al. Autophagy, 2021 Dec. PMID 33779490, Free PMC Article
    3. PI3P-dependent regulation of cell size and autophagy by phosphatidylinositol 5-phosphate 4-kinase. Ghosh A, et al. Life Sci Alliance, 2023 Sep. PMID 37316298, Free PMC Article
    4. Comparative transcriptional profiling and evolutionary analysis of the GRAM domain family in eukaryotes. Jiang SY, et al. Dev Biol, 2008 Feb 15. PMID 18201690
    5. MetaBlasts: tracing protein tyrosine phosphatase gene family roots from Man to Drosophila melanogaster and Caenorhabditis elegans genomes. Wälchli S, et al. Gene, 2000 Aug 8. PMID 10940550

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3-phosphate phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein tyrosine/serine/threonine phosphatase activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myotubularin related protein 6
    Names
    CG3530-PA
    CG3530-PB
    CG3530-PC
    MYOTUBULARIN-like
    Mtmr6-PA
    Mtmr6-PB
    Mtmr6-PC
    NP_001097433.1
    NP_611791.2
    NP_726322.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23389009..23396680 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137947.3 → NP_611791.2  myotubularin related protein 6, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611791.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9V3A1, Q9W1Q6
      Related
      FBpp0071937
      Conserved Domains (3) summary
      cd13210
      Location:4 → 101
      PH-GRAM_MTMR6-like; Myotubularian (MTM) related (MTMR) 7 and 8 proteins Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15738
      Location:621 → 681
      FYVE_MTMR_unchar; FYVE-related domain found in uncharacterized myotubularin-related proteins mainly from eumetazoa
      pfam06602
      Location:107 → 442
      Myotub-related; Myotubularin-like phosphatase domain

    2. NM_001103963.2 → NP_001097433.1  myotubularin related protein 6, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097433.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KK51
      Conserved Domains (3) summary
      cd15738
      Location:571 → 631
      FYVE_MTMR_unchar; FYVE-related domain found in uncharacterized myotubularin-related proteins mainly from eumetazoa
      pfam06602
      Location:57 → 392
      Myotub-related; Myotubularin-like phosphatase domain
      cl17171
      Location:1 → 51
      PH-like; Pleckstrin homology-like domain

    3. NM_166603.2 → NP_726322.1  myotubularin related protein 6, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726322.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MLR7
      Related
      FBpp0071938
      Conserved Domains (3) summary
      cd13210
      Location:78 → 173
      PH-GRAM_MTMR6-like; Myotubularian (MTM) related (MTMR) 7 and 8 proteins Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain
      cd15738
      Location:693 → 753
      FYVE_MTMR_unchar; FYVE-related domain found in uncharacterized myotubularin-related proteins mainly from eumetazoa
      pfam06602
      Location:179 → 514
      Myotub-related; Myotubularin-like phosphatase domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KK51 Q7KK51
    Q8MLR7 Q8MLR7
    Q9W1Q6 Q9W1Q6

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