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    Klp59D Kinesin-like protein at 59D [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37674, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Klp59Dprovided by FlyBase
    Official Full Name
    Kinesin-like protein at 59Dprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034827
    Locus tag
    Dmel_CG12192
    See related
    AllianceGenome:FB:FBgn0034827
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12192; Dmel\CG12192; DmKlp59D; KIF2A/B/C; KLP59D
    Summary
    Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Involved in regulation of motile cilium assembly and sperm axoneme assembly. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule cytoskeleton. Is expressed in adult head. Orthologous to human KIF2C (kinesin family member 2C). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Klp59D in Genome Data Viewer
    Location:
    59D1-59D1; 2-102 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (23141999..23144497)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (19029522..19032020)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Glycerol-3-phosphate dehydrogenase 2 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression levels of a kinesin-13 microtubule depolymerase modulates the effectiveness of anti-microtubule agents. Schimizzi GV, et al. PLoS One, 2010 Jun 30. PMID 20614032, Free PMC Article
    2. Mini spindles, the XMAP215 homologue, suppresses pausing of interphase microtubules in Drosophila. Brittle AL, et al. EMBO J, 2005 Apr 6. PMID 15775959, Free PMC Article
    3. The Drosophila kinesin-13, KLP59D, impacts Pacman- and Flux-based chromosome movement. Rath U, et al. Mol Biol Cell, 2009 Nov. PMID 19793918, Free PMC Article
    4. Patronin regulates the microtubule network by protecting microtubule minus ends. Goodwin SS, et al. Cell, 2010 Oct 15. PMID 20946984, Free PMC Article
    5. Antagonistic activities of Klp10A and Orbit regulate spindle length, bipolarity and function in vivo. Laycock JE, et al. J Cell Sci, 2006 Jun 1. PMID 16723741

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of motile cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kinesin-like protein at 59D
    Names
    CG12192-PA
    Kinesin13A
    Klp59D-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      23141999..23144497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137918.3 → NP_611762.1  Kinesin-like protein at 59D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611762.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IHF4, Q9W1U1
      Related
      FBpp0071878
      Conserved Domains (2) summary
      cd01367
      Location:233 → 565
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group
      pfam00225
      Location:239 → 566
      Kinesin; Kinesin motor domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IHF4 Q8IHF4
    Q9W1U1 Q9W1U1

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