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    PolE2 DNA polymerase epsilon subunit 2 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 38661, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PolE2provided by FlyBase
    Official Full Name
    DNA polymerase epsilon subunit 2provided by FlyBase
    Primary source
    FLYBASE:FBgn0035644
    Locus tag
    Dmel_CG10489
    See related
    AllianceGenome:FB:FBgn0035644
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    10489; CG10489; Dmel\CG10489; DNApol-epsilon; DNApol-epsilon58; dpolepsilonp58; pol.epsilon 2; Pole2; POLE2
    Summary
    Predicted to enable DNA binding activity. Involved in DNA-templated DNA replication and positive regulation of DNA endoreduplication. Part of epsilon DNA polymerase complex. Orthologous to human POLE2 (DNA polymerase epsilon 2, accessory subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PolE2 in Genome Data Viewer
    Location:
    64F4-64F4; 3-15 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5895691..5897435, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5888791..5890535, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glutaminyl cyclase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Subunit protein-affinity isolation of Drosophila DNA polymerase catalytic subunit. Oshige M, et al. Protein Expr Purif, 2004 Jun. PMID 15135399
    2. Functional analysis of Drosophila DNA polymerase ε p58 subunit. Sahashi R, et al. Am J Cancer Res, 2013. PMID 24224125, Free PMC Article
    3. Association of Mutations in Replicative DNA Polymerase Genes with Human Disease: Possible Application of Drosophila Models for Studies. Yamaguchi M, et al. Int J Mol Sci, 2023 Apr 29. PMID 37175782, Free PMC Article
    4. A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses. Sun D, et al. Nat Struct Mol Biol, 2010 Oct. PMID 20818390
    5. Akirin proteins in development and disease: critical roles and mechanisms of action. Bosch PJ, et al. Cell Mol Life Sci, 2020 Nov. PMID 32361777, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA replication proofreading IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in DNA-templated DNA replication IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA-templated DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in error-prone translesion synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA endoreduplication IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell cycle process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of epsilon DNA polymerase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of epsilon DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of epsilon DNA polymerase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase epsilon subunit 2
    Names
    CG10489-PA
    DNA polymerase epsilon 58kD subunit
    DNA polymerase epsilon B subunit
    PolE2-PA
    Pole2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      5895691..5897435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_139738.2 → NP_647995.1  DNA polymerase epsilon subunit 2 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_647995.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A9UND8, D3DMG0, Q95RJ7, Q9VRQ7
      Related
      FBpp0076789
      Conserved Domains (2) summary
      pfam04042
      Location:287 → 484
      DNA_pol_E_B; DNA polymerase alpha/epsilon subunit B
      pfam12213
      Location:7 → 76
      Dpoe2NT; DNA polymerases epsilon N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VRQ7.1 Q9VRQ7

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