wdp windpipe [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: wdpprovided by FlyBase
Official Full Name: windpipeprovided by FlyBase
Primary source: FLYBASE:FBgn0034718
Locus tag: Dmel_CG3413
See related: AllianceGenome:FB:FBgn0034718
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG30504; CG3413; CT11415; CT39092; Dmel\CG3413; Wdp
Summary: Involved in several processes, including negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of stem cell proliferation; and synaptic target recognition. Located in plasma membrane. Is expressed in several structures, including adult head; primary segmental tracheal branch primordium; and primary tracheal branch. [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 58D3-58D3; 2-99 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (22298214..22311937, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (18185719..18199442, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Regulation of morphogen pathways by a Drosophila chondroitin sulfate proteoglycan Windpipe.
Title: Regulation of morphogen pathways by a Drosophila chondroitin sulfate proteoglycan Windpipe.
Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila.
Title: Chondroitin sulfate proteoglycan Windpipe modulates Hedgehog signaling in Drosophila.
these data led us to propose that Wdp acts as a novel negative feedback regulator of the JAK/STAT pathway in regulating intestinal homeostasis
Title: Windpipe controls Drosophila intestinal homeostasis by regulating JAK/STAT pathway via promoting receptor endocytosis and lysosomal degradation.
sequence and expression analysis of a novel tracheal gene, named windpipe (wdp). wdp is identical to the predicted gene CG3413 and encodes a transmembrane, leucine-rich repeat family member. wdp transcripts appear abruptly at stage 15
Title: Drosophila windpipe codes for a leucine-rich repeat protein expressed in the developing trachea.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of stem cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synaptic target recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trachea development	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	ISM Inferred from Sequence Model more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: windpipe

Names: CG3413-PA; CG3413-PB; CG3413-PC; CG3413-PD; CG3413-PE; connectin-like; wdp-PA; wdp-PB; wdp-PC; wdp-PD; wdp-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

22298214..22311937 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_166526.2 → NP_726189.1 windpipe, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726189.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1NZE9, Q8IGN2, Q95U72, Q9W266

Related

FBpp0071761

Conserved Domains (3) summary

cd00116
Location:31 → 176

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:73 → 93

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:112 → 169

LRR_8; Leucine rich repeat
NM_137817.3 → NP_611661.1 windpipe, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_611661.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1NZE9, Q8IGN2, Q95U72, Q9W266

Related

FBpp0071760

Conserved Domains (3) summary

cd00116
Location:31 → 176

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:73 → 93

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:112 → 169

LRR_8; Leucine rich repeat
NM_166525.2 → NP_726188.1 windpipe, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726188.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1NZE9, Q8IGN2, Q95U72, Q9W266

Related

FBpp0071762

Conserved Domains (3) summary

cd00116
Location:31 → 176

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:73 → 93

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:112 → 169

LRR_8; Leucine rich repeat
NM_166524.2 → NP_726187.1 windpipe, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726187.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1NZE9, Q8IGN2, Q95U72, Q9W266

Related

FBpp0071763

Conserved Domains (3) summary

cd00116
Location:31 → 176

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:73 → 93

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:112 → 169

LRR_8; Leucine rich repeat
NM_001299783.1 → NP_001286712.1 windpipe, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286712.1

Status: REVIEWED

UniProtKB/Swiss-Prot

E1NZE9, Q8IGN2, Q95U72, Q9W266

Conserved Domains (3) summary

cd00116
Location:31 → 176

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00031
Location:73 → 93

LRR_1; leucine-rich repeat [structural motif]

pfam13855
Location:112 → 169

LRR_8; Leucine rich repeat