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    trio trio [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43974, updated on 9-Dec-2024

    Summary

    Official Symbol
    trioprovided by FlyBase
    Official Full Name
    trioprovided by FlyBase
    Primary source
    FLYBASE:FBgn0024277
    Locus tag
    Dmel_CG18214
    See related
    AllianceGenome:FB:FBgn0024277
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    0368/10; 0959/14; 1372/03; 1386/06; BEST:LD36950; CG18214; CG9208; Dmel\CG18214; dTrio; DTrio; l(3)036810; l(3)6D104; l(3)S036810; l(3)S095914; l(3)S137203; l(3)S138606; l(3)S[1372/3]; l(3)S[1386/06]; l(3)trio; M89; Trio; TRIO; UNC-73/Trio
    Summary
    Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including nervous system development; positive regulation of Rho protein signal transduction; and positive regulation of synaptic assembly at neuromuscular junction. Located in growth cone. Is extrinsic component of cytoplasmic side of plasma membrane. Is expressed in several structures, including epidermis; mushroom body; synaptic neuropil domain; synaptic neuropil subdomain; and ventral nerve cord. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal dominant intellectual developmental disorder 44; cerebral atherosclerosis; cerebral infarction; and coronary artery disease. Orthologous to human KALRN (kalirin RhoGEF kinase) and TRIO (trio Rho guanine nucleotide exchange factor). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See trio in Genome Data Viewer
    Location:
    61E1-61E2; 3-0.5 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (995982..1034875, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (995982..1034875, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Glucose transporter 1 Neighboring gene long non-coding RNA:CR45810 Neighboring gene long non-coding RNA:CR45811 Neighboring gene allnighter Neighboring gene uncharacterized protein Neighboring gene bric a brac 1 Neighboring gene bric a brac 2

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin cytoskeleton organization IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in axon guidance IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in axon target recognition IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in central nervous system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in imaginal disc-derived leg morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mushroom body development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peripheral nervous system development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in peripheral nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of synaptic assembly at neuromuscular junction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of axonogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in axon IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extrinsic component of cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extrinsic component of membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    trio
    Names
    CG18214-PA
    CG18214-PB
    CG18214-PC
    CG18214-PD
    CG18214-PE
    CG18214-PF
    CG18214-PG
    trio-PA
    trio-PB
    trio-PC
    trio-PD
    trio-PE
    trio-PF
    trio-PG

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      995982..1034875 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_143703.3NP_651960.2  trio, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651960.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVD1, Q9W0L0, Q9W0L1
      Related
      FBpp0072539
      Conserved Domains (8) summary
      smart00150
      Location:11251226
      SPEC; Spectrin repeats
      cd11852
      Location:16431707
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:13152
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00176
      Location:782997
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14621584
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21302260
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:14951580
      PH; PH domain
      pfam00621
      Location:12871456
      RhoGEF; RhoGEF domain
    2. NM_167847.2NP_728560.1  trio, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728560.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KVD1, Q9W0L0, Q9W0L1
      Related
      FBpp0072540
      Conserved Domains (8) summary
      smart00150
      Location:11251226
      SPEC; Spectrin repeats
      cd11852
      Location:16431707
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      smart00516
      Location:13152
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      cd00176
      Location:782997
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cd13240
      Location:14621584
      PH1_Kalirin_Trio_like; Triple functional domain pleckstrin homology pleckstrin homology (PH) domain, repeat 1
      cd13241
      Location:21302260
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00169
      Location:14951580
      PH; PH domain
      pfam00621
      Location:12871456
      RhoGEF; RhoGEF domain
    3. NM_167848.2NP_728561.1  trio, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728561.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IRI5
      Related
      FBpp0072541
      Conserved Domains (3) summary
      cd11852
      Location:184248
      SH3_Kalirin_1; First Src homology 3 domain of the RhoGEF kinase, Kalirin
      cd13241
      Location:671801
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:486663
      RhoGEF; RhoGEF domain
    4. NM_167849.2NP_728562.1  trio, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728562.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZA0, Q8T987
      Related
      FBpp0072542
      Conserved Domains (2) summary
      cd13241
      Location:525655
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:340517
      RhoGEF; RhoGEF domain
    5. NM_167850.2NP_728563.1  trio, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728563.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV43, Q8IRI4
      Related
      FBpp0072543
      Conserved Domains (2) summary
      cd13241
      Location:265395
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:80257
      RhoGEF; RhoGEF domain
    6. NM_206228.2NP_995950.1  trio, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995950.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7YZA0, Q8T987
      Conserved Domains (2) summary
      cd13241
      Location:525655
      PH2_Kalirin_Trio_p63RhoGEF; p63RhoGEF pleckstrin homology (PH) domain, repeat 2
      pfam00621
      Location:340517
      RhoGEF; RhoGEF domain
    7. NM_001414065.1NP_001401024.1  trio, isoform G [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A9F2H0X5