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    Hyccin hyccin [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 37019, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hyccinprovided by FlyBase
    Official Full Name
    hyccinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034269
    Locus tag
    Dmel_CG6406
    See related
    AllianceGenome:FB:FBgn0034269
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6406; Dmel\CG6406; FAM126A; hyccin
    Summary
    Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and protein localization to plasma membrane. Predicted to be active in plasma membrane. Is expressed in adult head. Used to study hypomyelinating leukodystrophy 5. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy 5. Orthologous to human HYCC1 (hyccin PI4KA lipid kinase complex subunit 1) and HYCC2 (hyccin PI4KA lipid kinase complex subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hyccin in Genome Data Viewer
    Location:
    54E4-54E4; 2-84 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (17734419..17737269, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (13621924..13624774, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Dachs ligand with SH3s Neighboring gene Sorting nexin 16 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class A Neighboring gene Vacuolar protein sorting 50

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. TTC7 and Hyccin Regulate Neuronal Aβ42 Accumulation and its Associated Neural Deficits in Aβ42-Expressing Drosophila. Sun M, et al. J Alzheimers Dis, 2018. PMID 30103315
    2. Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIα in Drosophila. Zhang Q, et al. Biochem Biophys Res Commun, 2022 Jan 22. PMID 34894559
    3. Genetic Dissection of Alzheimer's Disease Using Drosophila Models. Jeon Y, et al. Int J Mol Sci, 2020 Jan 30. PMID 32019113, Free PMC Article
    4. Behavioral screening of sleep-promoting effects of human intestinal and food-associated bacteria on Drosophila melanogaster. Ko T, et al. Genes Cells, 2023 Jun. PMID 36914986, Free PMC Article
    5. Latitudinal clines in gene expression and cis-regulatory element variation in Drosophila melanogaster. Juneja P, et al. BMC Genomics, 2016 Nov 28. PMID 27894253, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIalpha in Drosophila.
      Title: Hyccin/FAM126A deficiency reduces glial enrichment and axonal sheath, which are rescued by overexpression of a plasma membrane-targeting PI4KIIIα in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization to plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    hyccin
    Names
    CG6406-PA
    CG6406-PB
    Hyccin-PA
    Hyccin-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      17734419..17737269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166247.3 → NP_725714.1  hyccin, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725714.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1C5
      Related
      FBpp0086044
      Conserved Domains (1) summary
      pfam09790
      Location:20 → 346
      Hyccin; Hyccin

    2. NM_137412.4 → NP_611256.1  hyccin, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611256.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7K1C5
      Related
      FBpp0086043
      Conserved Domains (1) summary
      pfam09790
      Location:20 → 346
      Hyccin; Hyccin
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7K1C5 Q7K1C5

    Gene LinkOut

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