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    CG8389 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 36764, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG8389provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0034063
    Locus tag
    Dmel_CG8389
    See related
    AllianceGenome:FB:FBgn0034063
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG8389
    Summary
    Predicted to enable monocarboxylic acid transmembrane transporter activity. Predicted to be involved in monocarboxylic acid transport. Predicted to be active in plasma membrane. Is expressed in adult fat body and adult head. Human ortholog(s) of this gene implicated in cataract 47. Orthologous to human SLC16A12 (solute carrier family 16 member 12); SLC16A3 (solute carrier family 16 member 3); and SLC16A5 (solute carrier family 16 member 5). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG8389 in Genome Data Viewer
    Location:
    52D12-52D13; 2-76 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16008339..16013815)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11895844..11901320)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ATP citrate lyase Neighboring gene Transmembrane protein 131 Neighboring gene Ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene uncharacterized protein Neighboring gene Proteasome beta1 subunit Neighboring gene Rrp42 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glial Glycolysis Is Essential for Neuronal Survival in Drosophila. Volkenhoff A, et al. Cell Metab, 2015 Sep 1. PMID 26235423
    2. Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets. Rehwinkel J, et al. RNA, 2005 Oct. PMID 16199763, Free PMC Article
    3. The circadian clock interacts with metabolic physiology to influence reproductive fitness. Xu K, et al. Cell Metab, 2011 Jun 8. PMID 21641546, Free PMC Article
    4. Mobile-phone radiation-induced perturbation of gene-expression profiling, redox equilibrium and sporadic-apoptosis control in the ovary of Drosophila melanogaster. Manta AK, et al. Fly (Austin), 2017 Apr 3. PMID 27960592, Free PMC Article
    5. Reproductive status alters transcriptomic response to infection in female Drosophila melanogaster. Short SM, et al. G3 (Bethesda), 2013 May 20. PMID 23550122, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables monocarboxylic acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in monocarboxylic acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG8389-PA
    CG8389-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      16008339..16013815
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_137232.4 → NP_611076.2  uncharacterized protein Dmel_CG8389, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_611076.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E960, Q500Y2
      Related
      FBpp0086346
      Conserved Domains (2) summary
      cd06174
      Location:19 → 425
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:19 → 400
      MFS_1; Major Facilitator Superfamily

    2. NM_166132.3 → NP_725515.1  uncharacterized protein Dmel_CG8389, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_725515.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0E960, Q500Y2
      Related
      FBpp0086347
      Conserved Domains (2) summary
      cd06174
      Location:19 → 425
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:19 → 400
      MFS_1; Major Facilitator Superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0E960 Q0E960
    Q95TH5 Q95TH5

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