Vps16B Vacuolar protein sorting 16B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Vps16Bprovided by FlyBase
Official Full Name: Vacuolar protein sorting 16Bprovided by FlyBase
Primary source: FLYBASE:FBgn0039702
Locus tag: Dmel_CG18112
See related: AllianceGenome:FB:FBgn0039702
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG18112; Dmel\CG18112; dVps16B; fob; Vps16b
Summary: Involved in cellular response to peptidoglycan; immune response; and phagosome-lysosome fusion. Part of HOPS complex. Used to study ARC syndrome. Human ortholog(s) of this gene implicated in arthrogryposis, renal dysfunction, and cholestasis 2. Orthologous to human VIPAS39 (VPS33B interacting protein, apical-basolateral polarity regulator, spe-39 homolog). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (29814921..29816451, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (25640643..25642173, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Here, we describe a mutation in the full-of-bacteria (fob) gene, which encodes Drosophila Vps16B
Title: The full-of-bacteria gene is required for phagosome maturation during immune defense in Drosophila.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to peptidoglycan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endosomal transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in phagosome maturation	IDA Inferred from Direct Assay more info	PubMed
involved_in phagosome-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of SNARE complex assembly	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in vacuolar transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of CORVET complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of HOPS complex	IDA Inferred from Direct Assay more info	PubMed
part_of HOPS complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info

NEW Try the new Transcript table

The following sections contain reference sequences that belong to a specific genome build. Explain