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    SppL Signal peptide peptidase-like [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43128, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SppLprovided by FlyBase
    Official Full Name
    Signal peptide peptidase-likeprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039381
    Locus tag
    Dmel_CG17370
    See related
    AllianceGenome:FB:FBgn0039381
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG17370; CG5901; Dmel\CG17370; sppL; Sppl; SPPL3
    Summary
    Enables aspartic endopeptidase activity, intramembrane cleaving. Involved in signal peptide processing. Located in Golgi apparatus; endoplasmic reticulum; and membrane. Is expressed in several structures, including Malpighian tubule main body primordium; Malpighian tubule primordium; adult head; embryonic/larval midgut primordium; and gut section. Orthologous to human SPPL3 (signal peptide peptidase like 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See SppL in Genome Data Viewer
    Location:
    96F5-96F6; 3-89 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (25881984..25888230)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (21707706..21713952)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Tetraspanin 96F Neighboring gene Lnk Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A C-terminal region of signal peptide peptidase defines a functional domain for intramembrane aspartic protease catalysis. Narayanan S, et al. J Biol Chem, 2007 Jul 13. PMID 17517891
    2. Identification of a novel family of presenilin homologues. Ponting CP, et al. Hum Mol Genet, 2002 May 1. PMID 11978763
    3. Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease. Miller JP, et al. Neuron, 2010 Jul 29. PMID 20670829, Free PMC Article
    4. Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease. Casso DJ, et al. PLoS One, 2012. PMID 22439002, Free PMC Article
    5. piggyBac-based insertional mutagenesis in the presence of stably integrated P elements in Drosophila. Hacker U, et al. Proc Natl Acad Sci U S A, 2003 Jun 24. PMID 12802016, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Expression and characterization of signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease.
      Title: Expression and characterization of Drosophila signal peptide peptidase-like (sppL), a gene that encodes an intramembrane protease.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aspartic endopeptidase activity, intramembrane cleaving IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aspartic endopeptidase activity, intramembrane cleaving IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables aspartic endopeptidase activity, intramembrane cleaving IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in membrane protein proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal peptide processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in Golgi-associated vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasmic side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in lumenal side of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signal peptide peptidase-like
    Names
    CG17370-PA
    CG17370-PB
    CG17370-PC
    CG17370-PD
    CG17370-PE
    CG17370-PF
    SPP-like protein 3
    SppL-PA
    SppL-PB
    SppL-PC
    SppL-PD
    SppL-PE
    SppL-PF
    NP_001163740.1
    NP_001163741.1
    NP_001287535.1
    NP_651437.1
    NP_733123.1
    NP_733124.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      25881984..25888230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170269.2 → NP_001163740.1  signal peptide peptidase-like, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163740.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDN0, Q86P97
      Conserved Domains (1) summary
      pfam04258
      Location:102 → 413
      Peptidase_A22B; Signal peptide peptidase

    2. NM_143180.2 → NP_651437.1  signal peptide peptidase-like, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651437.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDN0, Q9VBL1
      Related
      FBpp0084283
      Conserved Domains (1) summary
      pfam04258
      Location:96 → 408
      Peptidase_A22B; Signal peptide peptidase

    3. NM_001300606.1 → NP_001287535.1  signal peptide peptidase-like, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001287535.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDN0, Q9VBL1
      Conserved Domains (1) summary
      pfam04258
      Location:96 → 408
      Peptidase_A22B; Signal peptide peptidase

    4. NM_001170270.2 → NP_001163741.1  signal peptide peptidase-like, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163741.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDN0, Q86P97
      Conserved Domains (1) summary
      pfam04258
      Location:102 → 413
      Peptidase_A22B; Signal peptide peptidase

    5. NM_170244.2 → NP_733123.1  signal peptide peptidase-like, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733123.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDN0, Q9VBL1
      Related
      FBpp0084284
      Conserved Domains (1) summary
      pfam04258
      Location:96 → 408
      Peptidase_A22B; Signal peptide peptidase

    6. NM_170245.2 → NP_733124.1  signal peptide peptidase-like, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_733124.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F3YDN0, Q9VBL1
      Related
      FBpp0084285
      Conserved Domains (1) summary
      pfam04258
      Location:96 → 408
      Peptidase_A22B; Signal peptide peptidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86P97 Q86P97
    Q9VBL1 Q9VBL1

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