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    Pebp1 Phosphatidylethanolamine-binding protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42644, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pebp1provided by FlyBase
    Official Full Name
    Phosphatidylethanolamine-binding protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0038973
    Locus tag
    Dmel_CG18594
    See related
    AllianceGenome:FB:FBgn0038973
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:LP12095; CG18594; Dmel\CG18594; PEBP1; T2
    Summary
    Involved in defense response to bacterium; negative regulation of ERK1 and ERK2 cascade; and regulation of antimicrobial humoral response. Located in cytosol. Is expressed in several structures, including anterior-posterior subdivision of organism; embryonic/larval fat body; embryonic/larval salivary gland; gastric caecum; and gut. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Pebp1 in Genome Data Viewer
    Location:
    94A16-94A16; 3-74 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (22466034..22466679)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (18291756..18292401)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Adaptor Protein complex 2, mu subunit Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Neurexin 1 Neighboring gene mir-4952 stem loop

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning, high yield over-expression, purification, and characterization of CG18594, a new PEBP/RKIP family member from Drosophila melanogaster. Rautureau G, et al. Protein Expr Purif, 2006 Jul. PMID 16529946
    2. Drosophila PEBP1 inhibits intestinal stem cell aging via suppression of ERK pathway. Pyo JH, et al. Oncotarget, 2018 Apr 6. PMID 29719584, Free PMC Article
    3. Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells. Ureña E, et al. Proc Natl Acad Sci U S A, 2024 Jan 23. PMID 38241436, Free PMC Article
    4. Expression and characterization of the PEBP homolog genes from Drosophila. Rautureau G, et al. Arch Insect Biochem Physiol, 2009 Jun. PMID 19309003
    5. Mbf1 ensures Polycomb silencing by protecting E(z) mRNA from degradation by Pacman. Nishioka K, et al. Development, 2018 Mar 9. PMID 29523653, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. transgenic flies overexpressing the protein are highly protected against bacterial infection
      Title: Unraveling the protective effect of a Drosophila phosphatidylethanolamine-binding protein upon bacterial infection by means of proteomics.
    2. CG18594 was not expressed in embryos whatever the developmental stage, was detected in all larval tissues tested, and was only found in ovaries and gut of adult Drosophila.
      Title: Expression and characterization of the PEBP homolog genes from Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in defense response to Gram-negative bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in defense response to Gram-positive bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of antimicrobial humoral response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Phosphatidylethanolamine-binding protein 1
    Names
    CG18594-PA
    Pebp1-PA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      22466034..22466679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_142794.3 → NP_651051.1  Phosphatidylethanolamine-binding protein 1 [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651051.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VD01
      Related
      FBpp0083648
      Conserved Domains (1) summary
      cd00866
      Location:20 → 162
      PEBP_euk; PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in eukaryotes
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VD01 Q9VD01

    Gene LinkOut

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