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    meigo medial glomeruli [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42510, updated on 17-Dec-2024

    Summary

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    Official Symbol
    meigoprovided by FlyBase
    Official Full Name
    medial glomeruliprovided by FlyBase
    Primary source
    FLYBASE:FBgn0250820
    Locus tag
    Dmel_CG5802
    See related
    AllianceGenome:FB:FBgn0250820
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-EST:fe1H6; CG5802; Dmel\CG5802; Meigo; NEST:bs03h03
    Summary
    Predicted to enable UDP-galactose transmembrane transporter activity and UDP-glucose transmembrane transporter activity. Involved in neuron projection guidance; protein N-linked glycosylation; and response to endoplasmic reticulum stress. Located in endoplasmic reticulum membrane. Is expressed in several structures, including adult head; adult heart; embryonic proventriculus intermediate layer; gut section; and yolk. Orthologous to human SLC35B1 (solute carrier family 35 member B1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See meigo in Genome Data Viewer
    Location:
    93C1-93C1; 3-71 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (21138270..21140365)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (16963992..16966087)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene tRNA methyltransferase 7-34 Neighboring gene SNF4/AMP-activated protein kinase gamma subunit Neighboring gene Ubiquitin specific protease 8 Neighboring gene Common Dpr-interacting protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Endoplasmic reticulum proteins Meigo and Gp93 govern dendrite targeting by regulating Toll-6 localization. Kamemura K, et al. Dev Biol, 2022 Apr. PMID 35134382
    2. Identification and characterization of a novel Drosophila 3'-phosphoadenosine 5'-phosphosulfate transporter. Goda E, et al. J Biol Chem, 2006 Sep 29. PMID 16873373
    3. Natural variation of ebony gene controlling thoracic pigmentation in Drosophila melanogaster. Takahashi A, et al. Genetics, 2007 Oct. PMID 17660557, Free PMC Article
    4. A mechanism for circadian control of pacemaker neuron excitability. Ruben M, et al. J Biol Rhythms, 2012 Oct. PMID 23010658, Free PMC Article
    5. ECM stiffness regulates glial migration in Drosophila and mammalian glioma models. Kim SN, et al. Development, 2014 Aug. PMID 25063458

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Endoplasmic reticulum proteins Meigo and Gp93 govern dendrite targeting by regulating Toll-6 localization.
      Title: Endoplasmic reticulum proteins Meigo and Gp93 govern dendrite targeting by regulating Toll-6 localization.
    2. Meigo, an endoplasmic reticulum (ER)-resident protein, governs neuronal targeting specificity by regulating ER folding capacity and protein N-glycosylation.
      Title: Meigo governs dendrite targeting specificity by modulating ephrin level and N-glycosylation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables UDP-galactose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucose transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in UDP-galactose transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dendrite guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein N-linked glycosylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    medial glomeruli
    Names
    CG5802-PA
    CG5802-PB
    NEST:bs03h03
    anon-fast-evolving-1H6
    meigo-PA
    meigo-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      21138270..21140365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104383.2 → NP_001097853.1  medial glomeruli, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097853.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JR61, Q9VDD7
      Conserved Domains (2) summary
      pfam08449
      Location:8 → 311
      UAA; UAA transporter family
      cl23754
      Location:169 → 308
      EamA; EamA-like transporter family

    2. NM_142692.3 → NP_650949.1  medial glomeruli, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650949.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JR61, Q9VDD7
      Related
      FBpp0083420
      Conserved Domains (2) summary
      pfam08449
      Location:8 → 311
      UAA; UAA transporter family
      cl23754
      Location:169 → 308
      EamA; EamA-like transporter family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VDD7.1 Q9VDD7

    Gene LinkOut

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    Other Literature Sources
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