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    Tssk Testis-specific serine/threonine kinase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 42233, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tsskprovided by FlyBase
    Official Full Name
    Testis-specific serine/threonine kinaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038630
    Locus tag
    Dmel_CG14305
    See related
    AllianceGenome:FB:FBgn0038630
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG14305; Dmel\CG14305; dTSSK
    Summary
    Enables protein serine/threonine kinase activity. Involved in spermatogenesis. Located in nucleus. Is expressed in adult head and testis. Orthologous to several human genes including TSSK2 (testis specific serine kinase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Tssk in Genome Data Viewer
    Location:
    91B5-91B5; 3-64 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18598691..18600097)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (14424413..14425819)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene hemotin Neighboring gene uncharacterized protein Neighboring gene frayed Neighboring gene uncharacterized protein Neighboring gene qin Neighboring gene transfer RNA:Proline-TGG 1-5 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Broad phosphorylation mediated by testis-specific serine/threonine kinases contributes to spermiogenesis and male fertility. Zhang X, et al. Nat Commun, 2023 May 6. PMID 37149634, Free PMC Article
    2. The Drosophila Translational Control Element (TCE) is required for high-level transcription of many genes that are specifically expressed in testes. Katzenberger RJ, et al. PLoS One, 2012. PMID 22984601, Free PMC Article
    3. Analysis of genes within the schizophrenia-linked 22q11.2 deletion identifies interaction of night owl/LZTR1 and NF1 in GABAergic sleep control. Maurer GW, et al. PLoS Genet, 2020 Apr. PMID 32339168, Free PMC Article
    4. Numerous Serine/Threonine Kinases Affect Blood Cell Homeostasis in Drosophila melanogaster. Deichsel S, et al. Cells, 2024 Mar 26. PMID 38607015, Free PMC Article
    5. A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Yin Z, et al. Nat Cell Biol, 2013 Jul. PMID 23748611, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that the Translational Control Element (TCE) is necessary for the transcription of testes-specific genes Mst84Dc, Mst87F, CG7557, CG14305 and CG31245.
      Title: The Drosophila Translational Control Element (TCE) is required for high-level transcription of many genes that are specifically expressed in testes.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatid development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Testis-specific serine/threonine kinase
    Names
    CG14305-PA
    CG14305-PC
    CG14305-PD
    Tssk-PA
    Tssk-PC
    Tssk-PD
    testis-specific serine/threonine kinase
    NP_650732.1
    NP_732356.1
    NP_732357.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      18598691..18600097
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_169825.2 → NP_732357.1  Testis-specific serine/threonine kinase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732357.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE58
      Related
      FBpp0083056
      Conserved Domains (2) summary
      smart00220
      Location:28 → 287
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14080
      Location:27 → 291
      STKc_TSSK-like; Catalytic domain of testis-specific serine/threonine kinases and similar proteins

    2. NM_142475.2 → NP_650732.1  Testis-specific serine/threonine kinase, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_650732.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE58
      Related
      FBpp0083054, FBtr0083634
      Conserved Domains (2) summary
      smart00220
      Location:28 → 287
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14080
      Location:27 → 291
      STKc_TSSK-like; Catalytic domain of testis-specific serine/threonine kinases and similar proteins

    3. NM_169824.3 → NP_732356.1  Testis-specific serine/threonine kinase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_732356.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VE58
      Related
      FBpp0297098
      Conserved Domains (2) summary
      smart00220
      Location:28 → 287
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14080
      Location:27 → 291
      STKc_TSSK-like; Catalytic domain of testis-specific serine/threonine kinases and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VE58 Q9VE58

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