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    GCS2alpha Glucosidase 2 alpha subunit [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 49953, updated on 9-Dec-2024

    Summary

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    Official Symbol
    GCS2alphaprovided by FlyBase
    Official Full Name
    Glucosidase 2 alpha subunitprovided by FlyBase
    Primary source
    FLYBASE:FBgn0027588
    Locus tag
    Dmel_CG14476
    See related
    AllianceGenome:FB:FBgn0027588
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    BcDNA:GH04962; CG14476; clot#312; Dmel\CG14476
    Summary
    Predicted to enable glucan 1,3-alpha-glucosidase activity. Predicted to be involved in N-glycan processing. Located in endomembrane system and extracellular region. Is expressed in several structures, including adult head; adult heart; anterior endoderm; gut section; and mesoderm. Human ortholog(s) of this gene implicated in polycystic kidney disease; polycystic kidney disease 3; and polycystic liver disease. Orthologous to several human genes including GANAB (glucosidase II alpha subunit). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See GCS2alpha in Genome Data Viewer
    Location:
    20A4-20A4; 1-66 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (21600502..21605264, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (21471529..21476291, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46472 Neighboring gene long non-coding RNA:CR44711 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region
      Title: [Analysis of the structure and expression of the cluster of Drosophila melanogaster genes DIP1, CG32500, CG32819, and CG14476 in the flamenco gene region].
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c21604380-21604032 mobile_element_type = transposon:INE-1{}2000

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables alpha-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucan 1,3-alpha-glucosidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-glycan processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endomembrane system HDA PubMed 
    located_in extracellular region HDA PubMed 
    part_of glucosidase II complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    glucosidase 2 alpha subunit
    Names
    CG14476-PA
    CG14476-PB
    CG14476-PC
    CG14476-PD
    CG14476-PE
    GCS2alpha-PA
    GCS2alpha-PB
    GCS2alpha-PC
    GCS2alpha-PD
    GCS2alpha-PE
    alpha-glucosidase
    glucosidase II
    NP_652145.1
    NP_728434.1
    NP_728435.1
    NP_728436.1
    NP_728437.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      21600502..21605264 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_167758.2 → NP_728435.1  glucosidase 2 alpha subunit, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728435.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMM4
      Related
      FBpp0070058
      Conserved Domains (3) summary
      cd06603
      Location:362 → 833
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:224 → 362
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:343 → 792
      Glyco_hydro_31; Glycosyl hydrolases family 31

    2. NM_143888.5 → NP_652145.1  glucosidase 2 alpha subunit, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652145.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMM4
      Related
      FBpp0070057
      Conserved Domains (3) summary
      cd06603
      Location:362 → 833
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:224 → 362
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:343 → 792
      Glyco_hydro_31; Glycosyl hydrolases family 31

    3. NM_167757.3 → NP_728434.1  glucosidase 2 alpha subunit, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728434.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMM4
      Related
      FBpp0070059
      Conserved Domains (3) summary
      cd06603
      Location:362 → 833
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:224 → 362
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:343 → 792
      Glyco_hydro_31; Glycosyl hydrolases family 31

    4. NM_167760.1 → NP_728437.1  glucosidase 2 alpha subunit, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728437.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMM4
      Related
      FBpp0070060, FBtr0070061
      Conserved Domains (3) summary
      cd06603
      Location:362 → 833
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:224 → 362
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:343 → 792
      Glyco_hydro_31; Glycosyl hydrolases family 31

    5. NM_167759.2 → NP_728436.1  glucosidase 2 alpha subunit, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_728436.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KMM4
      Related
      FBpp0070061
      Conserved Domains (3) summary
      cd06603
      Location:362 → 833
      GH31_GANC_GANAB_alpha; neutral alpha-glucosidase C, neutral alpha-glucosidase AB
      cd14752
      Location:224 → 362
      GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
      pfam01055
      Location:343 → 792
      Glyco_hydro_31; Glycosyl hydrolases family 31
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KMM4 Q7KMM4

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