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    sni sniffer [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31761, updated on 27-Dec-2024

    Summary

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    Official Symbol
    sniprovided by FlyBase
    Official Full Name
    snifferprovided by FlyBase
    Primary source
    FLYBASE:FBgn0030026
    Locus tag
    Dmel_CG10964
    See related
    AllianceGenome:FB:FBgn0030026
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO03040301.183; CG10964; Dmel\CG10964; Sni; SNI
    Summary
    Enables carbonyl reductase (NADPH) activity. Located in mitochondrial matrix. Is expressed in adult head; adult heart; and organism. Used to study neurodegenerative disease. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See sni in Genome Data Viewer
    Location:
    7D22-7D22; 1-22 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8241501..8244016, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8135534..8138049, complement)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene stardust Neighboring gene uncharacterized protein Neighboring gene Thioredoxin reductase 1 Neighboring gene NADH dehydrogenase (ubiquinone) 75 kDa subunit Neighboring gene uncharacterized protein Neighboring gene Companion of reaper

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exposure to Spectracide® causes behavioral deficits in Drosophila melanogaster: Insights from locomotor analysis and molecular modeling. Chaudhuri A, et al. Chemosphere, 2020 Jun. PMID 32018111
    2. Structural insights into the neuroprotective-acting carbonyl reductase Sniffer of Drosophila melanogaster. Sgraja T, et al. J Mol Biol, 2004 Oct 1. PMID 15364585
    3. The Drosophila carbonyl reductase sniffer is an efficient 4-oxonon-2-enal (4ONE) reductase. Martin HJ, et al. Chem Biol Interact, 2011 May 30. PMID 21167142
    4. Withania somnifera and Centella asiatica Extracts Ameliorate Behavioral Deficits in an In Vivo Drosophila melanogaster Model of Oxidative Stress. Cabey K, et al. Antioxidants (Basel), 2022 Jan 6. PMID 35052625, Free PMC Article
    5. The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration. Botella JA, et al. Curr Biol, 2004 May 4. PMID 15120069

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study demonistrated that combined a null mutation in the clock gene period (per(01)) that abolishes circadian rhythms, with a hypomorphic mutation in the (sni(1)), which displays oxidative stress induced neurodegeneration.
      Title: Loss of circadian clock accelerates aging in neurodegeneration-prone mutants.
    2. sniffer catalyzed the NADPH-dependent carbonyl reduction of 4-oxonon-2-enal
      Title: The Drosophila carbonyl reductase sniffer is an efficient 4-oxonon-2-enal (4ONE) reductase.
    3. Sniffer exhibits carbonyl reductase activity and is essential for preventing age-related neurodegeneration.
      Title: The Drosophila carbonyl reductase sniffer prevents oxidative stress-induced neurodegeneration.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables carbonyl reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables carbonyl reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sniffer
    Names
    CG10964-PA
    CG10964-PB
    sni-PA
    sni-PB
    NP_001285012.1
    NP_572466.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8241501..8244016 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001298083.1 → NP_001285012.1  sniffer, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285012.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3H4
      Conserved Domains (2) summary
      cd05325
      Location:4 → 247
      carb_red_sniffer_like_SDR_c; carbonyl reductase sniffer-like, classical (c) SDRs
      pfam00106
      Location:4 → 209
      adh_short; short chain dehydrogenase

    2. NM_132238.3 → NP_572466.1  sniffer, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_572466.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9W3H4
      Related
      FBpp0071131
      Conserved Domains (2) summary
      cd05325
      Location:4 → 247
      carb_red_sniffer_like_SDR_c; carbonyl reductase sniffer-like, classical (c) SDRs
      pfam00106
      Location:4 → 209
      adh_short; short chain dehydrogenase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9W3H4 Q9W3H4

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