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    Abcd1 ATP binding cassette subfamily D member 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43772, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Abcd1provided by FlyBase
    Official Full Name
    ATP binding cassette subfamily D member 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0039890
    Locus tag
    Dmel_CG2316
    See related
    AllianceGenome:FB:FBgn0039890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ABCD; ABCD1/2; CG2316; dABCD; DmCG2316; Dmel\CG2316
    Summary
    Predicted to enable ABC-type fatty-acyl-CoA transporter activity; ATP binding activity; and long-chain fatty acid transmembrane transporter activity. Involved in long-chain fatty acid metabolic process. Predicted to be located in membrane. Predicted to be active in peroxisomal membrane. Is expressed in adult head. Used to study adrenoleukodystrophy. Human ortholog(s) of this gene implicated in adrenoleukodystrophy. Orthologous to human ABCD1 (ATP binding cassette subfamily D member 1) and ABCD2 (ATP binding cassette subfamily D member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Abcd1 in Genome Data Viewer
    Location:
    102A6-102A6; 4-0 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (184076..193829, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (204702..214455, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR46488 Neighboring gene ADP ribosylation factor-like 4 Neighboring gene long non-coding RNA:CR44441 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Etiology and treatment of adrenoleukodystrophy: new insights from Drosophila. Gordon HB, et al. Dis Model Mech, 2018 Jun 15. PMID 29739804, Free PMC Article
    2. SON protects nascent transcripts from unproductive degradation by counteracting DIP1. Tay ML, et al. PLoS Genet, 2019 Nov. PMID 31730657, Free PMC Article
    3. cis-Acting determinants of heterochromatin formation on Drosophila melanogaster chromosome four. Sun FL, et al. Mol Cell Biol, 2004 Sep. PMID 15340080, Free PMC Article
    4. Gene transposition as a cause of hybrid sterility in Drosophila. Masly JP, et al. Science, 2006 Sep 8. PMID 16960009
    5. Identification and characterization of a juvenile hormone response element and its binding proteins. Li Y, et al. J Biol Chem, 2007 Dec 28. PMID 17956872, Free PMC Article

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c185457-184965 mobile_element_type = transposon:INE-1{}4839
    • Loc: c193017-192640 mobile_element_type = transposon:INE-1{}4844

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ABC-type fatty-acyl-CoA transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables ABC-type transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATPase-coupled transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables long-chain fatty acid transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in fatty acid beta-oxidation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid import into peroxisome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in long-chain fatty acid import into peroxisome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ATP binding cassette subfamily D member 1
    Names
    ATP binding cassette subfamily D
    ATP-binding cassette, subfamily D, member 1
    Abcd1-PA
    Abcd1-PB
    Abcd1-PC
    Abcd1-PD
    Abcd1-PG
    Abcd1-PH
    CG2316-PA
    CG2316-PB
    CG2316-PC
    CG2316-PD
    CG2316-PG
    CG2316-PH
    NP_001245409.1
    NP_651906.1
    NP_726542.1
    NP_726543.1
    NP_726544.1
    NP_726546.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      184076..193829 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_166736.4 → NP_726542.1  ATP binding cassette subfamily D member 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726542.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JUN3
      Related
      FBpp0088215
      Conserved Domains (1) summary
      TIGR00954
      Location:75 → 715
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

    2. NM_166738.3 → NP_726544.1  ATP binding cassette subfamily D member 1, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726544.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JUN3
      Related
      FBpp0088213
      Conserved Domains (1) summary
      TIGR00954
      Location:75 → 715
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

    3. NM_166737.3 → NP_726543.1  ATP binding cassette subfamily D member 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726543.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JUN3
      Related
      FBpp0088214
      Conserved Domains (1) summary
      TIGR00954
      Location:75 → 715
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

    4. NM_143649.3 → NP_651906.1  ATP binding cassette subfamily D member 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651906.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JUN3
      Related
      FBpp0088217
      Conserved Domains (1) summary
      TIGR00954
      Location:75 → 715
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

    5. NM_166740.2 → NP_726546.1  ATP binding cassette subfamily D member 1, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_726546.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JUN3
      Related
      FBpp0088216
      Conserved Domains (1) summary
      TIGR00954
      Location:75 → 715
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein

    6. NM_001258480.1 → NP_001245409.1  ATP binding cassette subfamily D member 1, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001245409.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7JUN3
      Conserved Domains (1) summary
      TIGR00954
      Location:75 → 715
      3a01203; Peroxysomal Fatty Acyl CoA Transporter (FAT) Family protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JUN3.1 Q7JUN3

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