RNF32 ring finger protein 32 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RNF32provided by HGNC
Official Full Name: ring finger protein 32provided by HGNC
Primary source: HGNC:HGNC:17118
See related: Ensembl:ENSG00000105982 MIM:610241; AllianceGenome:HGNC:17118
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSD15; LMBR2; FKSG33
Summary: The protein encoded by this gene contains two RING ring finger motifs. RING finger motifs are present in a variety of functionally distinct proteins and are known to be involved in protein-DNA or protein-protein interactions. This gene was found to be expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Expression: Biased expression in testis (RPKM 12.4), bone marrow (RPKM 0.9) and 4 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q36.3

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (156640204..156677130)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (157827918..157864843)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (156433468..156469824)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

molecular cloning of a RING domain protein expressed during sperm formation
Title: A double RING-H2 domain in RNF32, a gene expressed during sperm formation.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2021-02-02) ClinGen Genome Curation Page Haploinsufficency Dosage sensitivity unlikely (Last evaluated 2021-02-02) ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:1318499 (e-PCR)
- UniSTS:74279

SHGC-132644 (e-PCR)
- UniSTS:185424

RH93169 (e-PCR)
- UniSTS:91737

RH94347 (e-PCR)
- UniSTS:89453

SHGC-36890 (e-PCR)
- UniSTS:34449

SHGC-58113 (e-PCR)
- UniSTS:46994

WI-11426 (e-PCR)
- UniSTS:15515

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in aggresome	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in endosome	IDA Inferred from Direct Assay more info
located_in nuclear body	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: RING finger protein 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001184996.2 → NP_001171925.1 RING finger protein 32 isoform a

See identical proteins and their annotated locations for NP_001171925.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1, 2 and 3 all encode isoform a.

Source sequence(s)

AK314067, AL136874

Consensus CDS

CCDS5944.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Related

ENSP00000405588.2, ENST00000432459.6

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain
NM_001184997.1 → NP_001171926.1 RING finger protein 32 isoform a

See identical proteins and their annotated locations for NP_001171926.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.

Source sequence(s)

AA412402, AF325690, AF441222

Consensus CDS

CCDS5944.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Related

ENSP00000376499.2, ENST00000392743.6

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain
NM_001308273.2 → NP_001295202.1 RING finger protein 32 isoform b

See identical proteins and their annotated locations for NP_001295202.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice site in the 3' terminal exon, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

AL136874, BC028120, DB198291

Consensus CDS

CCDS78293.1

UniProtKB/TrEMBL

G5E940

Related

ENSP00000308894.8, ENST00000311822.12

Conserved Domains (2) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif
NM_001308274.1 → NP_001295203.1 RING finger protein 32 isoform c

See identical proteins and their annotated locations for NP_001295203.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and contains alternate 3' exon structure, resulting in an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (c) has a distinct C-terminus and is shorter than isoform a.

Source sequence(s)

BC015416

Consensus CDS

CCDS78292.1

UniProtKB/TrEMBL

E9PES2

Related

ENSP00000376497.2, ENST00000392741.6

Conserved Domains (2) summary

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

cd16677
Location:126 → 169

RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
NM_030936.4 → NP_112198.1 RING finger protein 32 isoform a

See identical proteins and their annotated locations for NP_112198.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 all encode isoform a.

Source sequence(s)

AL136874, BI460257, DB445126

Consensus CDS

CCDS5944.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Related

ENSP00000315950.5, ENST00000317955.10

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain

RNA

NR_131778.1 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) contains an additional internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AF441224, AL136874

Related

ENST00000392747.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

156640204..156677130

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_024446666.2 → XP_024302434.1 RING finger protein 32 isoform X4

UniProtKB/TrEMBL

E9PES2

Related

ENSP00000385815.2, ENST00000404282.6

Conserved Domains (2) summary

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

cd16677
Location:126 → 169

RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
XM_011515811.3 → XP_011514113.1 RING finger protein 32 isoform X1

See identical proteins and their annotated locations for XP_011514113.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain
XM_047419904.1 → XP_047275860.1 RING finger protein 32 isoform X4
XM_011515810.3 → XP_011514112.1 RING finger protein 32 isoform X1

See identical proteins and their annotated locations for XP_011514112.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain
XM_047419894.1 → XP_047275850.1 RING finger protein 32 isoform X1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1
XM_011515808.4 → XP_011514110.1 RING finger protein 32 isoform X1

See identical proteins and their annotated locations for XP_011514110.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain
XM_011515809.4 → XP_011514111.1 RING finger protein 32 isoform X1

See identical proteins and their annotated locations for XP_011514111.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain
XM_047419899.1 → XP_047275855.1 RING finger protein 32 isoform X3

UniProtKB/TrEMBL

G5E940
XM_011515805.4 → XP_011514107.1 RING finger protein 32 isoform X1

See identical proteins and their annotated locations for XP_011514107.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Related

ENSP00000385285.1, ENST00000405335.5

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain
XM_047419898.1 → XP_047275854.1 RING finger protein 32 isoform X2
XM_047419895.1 → XP_047275851.1 RING finger protein 32 isoform X1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1
XM_011515806.4 → XP_011514108.1 RING finger protein 32 isoform X1

See identical proteins and their annotated locations for XP_011514108.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain
XM_011515812.4 → XP_011514114.1 RING finger protein 32 isoform X1

See identical proteins and their annotated locations for XP_011514114.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain
XM_011515804.4 → XP_011514106.1 RING finger protein 32 isoform X1

See identical proteins and their annotated locations for XP_011514106.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain
XM_011515813.3 → XP_011514115.1 RING finger protein 32 isoform X2

Conserved Domains (2) summary

pfam00612
Location:175 → 194

IQ; IQ calmodulin-binding motif

pfam13639
Location:278 → 339

zf-RING_2; Ring finger domain
XM_047419900.1 → XP_047275856.1 RING finger protein 32 isoform X4
XM_047419901.1 → XP_047275857.1 RING finger protein 32 isoform X4
XM_047419902.1 → XP_047275858.1 RING finger protein 32 isoform X4
XM_017011755.2 → XP_016867244.1 RING finger protein 32 isoform X4

UniProtKB/TrEMBL

E9PES2

Conserved Domains (2) summary

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

cd16677
Location:126 → 169

RING1-H2_RNF32; RING finger 1, H2 subclass, found in RING finger protein 32 (RNF32) and similar proteins
XM_047419905.1 → XP_047275861.1 RING finger protein 32 isoform X5
XM_005249522.6 → XP_005249579.1 RING finger protein 32 isoform X1

See identical proteins and their annotated locations for XP_005249579.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain
XM_047419903.1 → XP_047275859.1 RING finger protein 32 isoform X4
XM_047419897.1 → XP_047275853.1 RING finger protein 32 isoform X1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1
XM_047419896.1 → XP_047275852.1 RING finger protein 32 isoform X1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1
XM_011515807.4 → XP_011514109.1 RING finger protein 32 isoform X1

See identical proteins and their annotated locations for XP_011514109.1

UniProtKB/Swiss-Prot

Q6FIB3, Q6X7T4, Q8N6V8, Q8TDG0, Q96BM5, Q9H0A6, Q9Y6U1

Conserved Domains (3) summary

cd00162
Location:127 → 171

RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

pfam00612
Location:188 → 207

IQ; IQ calmodulin-binding motif

pfam13639
Location:291 → 352

zf-RING_2; Ring finger domain