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    ARIH2 ariadne RBR E3 ubiquitin protein ligase 2 [ Homo sapiens (human) ]

    Gene ID: 10425, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ARIH2provided by HGNC
    Official Full Name
    ariadne RBR E3 ubiquitin protein ligase 2provided by HGNC
    Primary source
    HGNC:HGNC:690
    See related
    Ensembl:ENSG00000177479 MIM:605615; AllianceGenome:HGNC:690
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ARI2; TRIAD1
    Summary
    The protein encoded by this gene is an E3 ubiquitin-protein ligase that polyubiquitinates some proteins, tagging them for degradation. The encoded protein upregulates p53 in some cancer cells and may inhibit myelopoiesis. Several transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been determined yet. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in thyroid (RPKM 18.6), heart (RPKM 17.4) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ARIH2 in Genome Data Viewer
    Location:
    3p21.31
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (48918842..48986382)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (48947848..49014431)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48956275..49023815)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14340 Neighboring gene PRKAR2A antisense RNA 1 Neighboring gene solute carrier family 25 member 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19844 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14341 Neighboring gene hESC enhancers GRCh37_chr3:48955152-48955902 and GRCh37_chr3:48955903-48956654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:48956655-48957405 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48959089-48959589 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48961592-48962092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48962093-48962593 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19846 Neighboring gene ARIH2 opposite strand lncRNA Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19847 Neighboring gene MPRA-validated peak4646 silencer Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:49000975-49001622 Neighboring gene uncharacterized LOC124909376 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49026394-49026957 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49026958-49027520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14344 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:49028085-49028646 Neighboring gene uncharacterized LOC124906235 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:49043602-49044590 Neighboring gene prolyl 4-hydroxylase, transmembrane Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:49051026-49051863 Neighboring gene WD repeat domain 6 Neighboring gene DALR anticodon binding domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia. Wang H, et al. Oncogene, 2018 May. PMID 29459712, Free PMC Article
    2. TRIAD1 is negatively regulated by the MDM2 E3 ligase. Bae S, et al. Oncol Rep, 2012 Nov. PMID 22940738
    3. ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination. Geng S, et al. Cell Death Dis, 2022 Jun 22. PMID 35732617, Free PMC Article
    4. Gfi1 ubiquitination and proteasomal degradation is inhibited by the ubiquitin ligase Triad1. Marteijn JA, et al. Blood, 2007 Nov 1. PMID 17646546
    5. Structure of the HHARI catalytic domain shows glimpses of a HECT E3 ligase. Spratt DE, et al. PLoS One, 2013. PMID 24058416, Free PMC Article

    See all (71) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.
      Title: ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.
    2. Here, using a quantitative proteomics approach, the authors identify the E3 ligase ARIH2 as a regulator of the HIV-1 Vif protein-dependent CRL5-mediated APOBEC3 degradation. The CUL5(Vif/CBFss) complex recruits ARIH2 where it acts to transfer ubiquitin directly to the APOBEC3 targets.
      Title: ARIH2 Is a Vif-Dependent Regulator of CUL5-Mediated APOBEC3G Degradation in HIV Infection.
    3. ubiquitin-associated (UBA) domain-containing DCNL1 is monoubiquitylated when bound to CRLs and that this monoubiquitylation depends on the CRL-associated Ariadne RBR ligases TRIAD1 (ARIH2) and HHARI (ARIH1) and strictly requires the DCNL1's UBA domain.
      Title: Coupled monoubiquitylation of the co-E3 ligase DCNL1 by Ariadne-RBR E3 ubiquitin ligases promotes cullin-RING ligase complex remodeling.
    4. Data found Mll-Ell increases Triad1 in a Hox-dependent manner. Triad1 antagonizes Mll-Ell-induced protein ubiquitination and progression to AML. Triad1 knockdown significantly shortened the latency to development of AML in mice transplanted with Mll-Ell-transduced bone marrow. Further results identify Triad1 as a leukemia suppressor in 11q23-AML.
      Title: The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.
    5. these findings reveal a novel mechanism of ubiquitination-dependent negative regulation of the NLRP3 inflammasome by ARIH2 and highlight ARIH2 as a potential therapeutic target for inflammatory diseases
      Title: ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.
    6. We show that ARIH2 E3-ligase regulates PABPN1 protein accumulation and aggregation
      Title: A novel feed-forward loop between ARIH2 E3-ligase and PABPN1 regulates aging-associated muscle degeneration.
    7. TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
      Title: TRIAD1 and HHARI bind to and are activated by distinct neddylated Cullin-RING ligase complexes.
    8. study demonstrated that TRIAD1 is a ubiquitination target for proteasome-dependent degradation by MDM2; results suggest TRIAD1 degradation by MDM2 suppresses TRIAD1-mediated cell growth; data suggested a novel negative regulatory mechanism of TRIAD1 via MDM2 E3 ligase ubiquitination
      Title: TRIAD1 is negatively regulated by the MDM2 E3 ligase.
    9. TRIAD1 as a novel modulator of the p53-MDM2 axis that induces p53 activation by inhibiting its regulation by MDM2.
      Title: TRIAD1 inhibits MDM2-mediated p53 ubiquitination and degradation.
    10. In sharp contrast to SIAH1/SIAH2 and UBCH8, TRIAD1 binding to PML-RARalpha has no effect on its turnover.
      Title: Differential regulation of PML-RARα stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ10938, FLJ33921

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin conjugating enzyme binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin conjugating enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in developmental cell growth IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in hematopoietic stem cell proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein targeting to mitochondrion HMP PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K63-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase ARIH2
    Names
    RING-type E3 ubiquitin transferase ARIH2
    all-trans retinoic acid inducible RING finger
    ariadne homolog 2
    protein ariadne-2 homolog
    NP_001304262.1
    NP_001304263.1
    NP_001336138.1
    NP_001336139.1
    NP_001336140.1
    NP_001336141.1
    NP_001336142.1
    NP_001336143.1
    NP_001336144.1
    NP_001336145.1
    NP_001336146.1
    NP_001336147.1
    NP_001336148.1
    NP_001336149.1
    NP_001336150.1
    NP_001336151.1
    NP_001336152.1
    NP_001336153.1
    NP_001336154.1
    NP_001336155.1
    NP_001336156.1
    NP_001336157.1
    NP_001336158.1
    NP_001336159.1
    NP_006312.1
    XP_011531570.1
    XP_011531573.1
    XP_016861023.1
    XP_016861024.1
    XP_024309077.1
    XP_024309079.1
    XP_047303221.1
    XP_047303223.1
    XP_047303234.1
    XP_047303239.1
    XP_047303240.1
    XP_054200902.1
    XP_054200903.1
    XP_054200904.1
    XP_054200905.1
    XP_054200906.1
    XP_054200907.1
    XP_054200908.1
    XP_054200909.1
    XP_054200910.1
    XP_054200911.1
    XP_054200912.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001317333.2 → NP_001304262.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), as well as variants 2, 4, 5, and 6, encodes isoform a.
      Source sequence(s)
      AC134028, AC137630, AK223550, AL110187
      Consensus CDS
      CCDS2780.1
      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
      Related
      ENSP00000403222.1, ENST00000449376.5
      Conserved Domains (3) summary
      smart00647
      Location:208 → 270
      IBR; In Between Ring fingers
      cd16773
      Location:137 → 190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:298 → 330
      IBR; IBR domain, a half RING-finger domain

    2. NM_001317334.2 → NP_001304263.1  E3 ubiquitin-protein ligase ARIH2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 7, encodes isoform b.
      Source sequence(s)
      AC137630, AL110187, BC000422, BG476221, BM928477
      UniProtKB/TrEMBL
      Q59HA2
      Conserved Domains (3) summary
      smart00647
      Location:66 → 128
      IBR; In Between Ring fingers
      cd16773
      Location:1 → 48
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:156 → 188
      IBR; IBR domain, a half RING-finger domain

    3. NM_001349209.2 → NP_001336138.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variants 1, 2, 5, and 6, encodes isoform a.
      Source sequence(s)
      AC134028, AC137630
      Consensus CDS
      CCDS2780.1
      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
      Conserved Domains (3) summary
      smart00647
      Location:208 → 270
      IBR; In Between Ring fingers
      cd16773
      Location:137 → 190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:298 → 330
      IBR; IBR domain, a half RING-finger domain

    4. NM_001349210.2 → NP_001336139.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1, 2, 4, and 6, encodes isoform a.
      Source sequence(s)
      AC134028, AC137630
      Consensus CDS
      CCDS2780.1
      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
      Conserved Domains (3) summary
      smart00647
      Location:208 → 270
      IBR; In Between Ring fingers
      cd16773
      Location:137 → 190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:298 → 330
      IBR; IBR domain, a half RING-finger domain

    5. NM_001349211.2 → NP_001336140.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 2, 4, and 5, encodes isoform a.
      Source sequence(s)
      AC134028, AC137630
      Consensus CDS
      CCDS2780.1
      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
      Conserved Domains (3) summary
      smart00647
      Location:208 → 270
      IBR; In Between Ring fingers
      cd16773
      Location:137 → 190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:298 → 330
      IBR; IBR domain, a half RING-finger domain

    6. NM_001349212.2 → NP_001336141.1  E3 ubiquitin-protein ligase ARIH2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variant 3, encodes isoform b.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q59HA2
      Conserved Domains (3) summary
      smart00647
      Location:66 → 128
      IBR; In Between Ring fingers
      cd16773
      Location:1 → 48
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:156 → 188
      IBR; IBR domain, a half RING-finger domain

    7. NM_001349213.2 → NP_001336142.1  E3 ubiquitin-protein ligase ARIH2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variant 9, encodes the longest isoform (c).
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:208 → 270
      IBR; In Between Ring fingers
      cd16773
      Location:137 → 190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

    8. NM_001349214.2 → NP_001336143.1  E3 ubiquitin-protein ligase ARIH2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variant 8, encodes the longest isoform (c).
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:208 → 270
      IBR; In Between Ring fingers
      cd16773
      Location:137 → 190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

    9. NM_001349215.2 → NP_001336144.1  E3 ubiquitin-protein ligase ARIH2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) encodes isoform d.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:208 → 270
      IBR; In Between Ring fingers
      pfam01485
      Location:298 → 330
      IBR; IBR domain, a half RING-finger domain
      cd16773
      Location:137 → 190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

    10. NM_001349216.2 → NP_001336145.1  E3 ubiquitin-protein ligase ARIH2 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) encodes isoform e.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:136 → 198
      IBR; In Between Ring fingers
      cd16773
      Location:65 → 118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

    11. NM_001349217.2 → NP_001336146.1  E3 ubiquitin-protein ligase ARIH2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 13, 14, 15, and 16, encodes isoform f.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:136 → 198
      IBR; In Between Ring fingers
      cd16773
      Location:65 → 118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226 → 258
      IBR; IBR domain, a half RING-finger domain

    12. NM_001349218.2 → NP_001336147.1  E3 ubiquitin-protein ligase ARIH2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 12, 14, 15, and 16, encodes isoform f.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:136 → 198
      IBR; In Between Ring fingers
      cd16773
      Location:65 → 118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226 → 258
      IBR; IBR domain, a half RING-finger domain

    13. NM_001349219.2 → NP_001336148.1  E3 ubiquitin-protein ligase ARIH2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 12, 13, 15, and 16, encodes isoform f.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:136 → 198
      IBR; In Between Ring fingers
      cd16773
      Location:65 → 118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226 → 258
      IBR; IBR domain, a half RING-finger domain

    14. NM_001349220.2 → NP_001336149.1  E3 ubiquitin-protein ligase ARIH2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 12, 13, 14, and 16, encodes isoform f.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:136 → 198
      IBR; In Between Ring fingers
      cd16773
      Location:65 → 118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226 → 258
      IBR; IBR domain, a half RING-finger domain

    15. NM_001349221.2 → NP_001336150.1  E3 ubiquitin-protein ligase ARIH2 isoform f

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 12, 13, 14, and 15, encodes isoform f.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:136 → 198
      IBR; In Between Ring fingers
      cd16773
      Location:65 → 118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:226 → 258
      IBR; IBR domain, a half RING-finger domain

    16. NM_001349222.2 → NP_001336151.1  E3 ubiquitin-protein ligase ARIH2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 18, 19, 20, and 21, encodes isoform g.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:124 → 186
      IBR; In Between Ring fingers
      cd16773
      Location:53 → 106
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:214 → 246
      IBR; IBR domain, a half RING-finger domain

    17. NM_001349223.2 → NP_001336152.1  E3 ubiquitin-protein ligase ARIH2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variants 17, 19, 20, and 21, encodes isoform g.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:124 → 186
      IBR; In Between Ring fingers
      cd16773
      Location:53 → 106
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:214 → 246
      IBR; IBR domain, a half RING-finger domain

    18. NM_001349224.2 → NP_001336153.1  E3 ubiquitin-protein ligase ARIH2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variants 17, 18, 20, and 21, encodes isoform g.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:124 → 186
      IBR; In Between Ring fingers
      cd16773
      Location:53 → 106
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:214 → 246
      IBR; IBR domain, a half RING-finger domain

    19. NM_001349225.2 → NP_001336154.1  E3 ubiquitin-protein ligase ARIH2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variants 17, 18, 19, and 21, encodes isoform g.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:124 → 186
      IBR; In Between Ring fingers
      cd16773
      Location:53 → 106
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:214 → 246
      IBR; IBR domain, a half RING-finger domain

    20. NM_001349226.2 → NP_001336155.1  E3 ubiquitin-protein ligase ARIH2 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 17, 18, 19, and 20, encodes isoform g.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (3) summary
      smart00647
      Location:124 → 186
      IBR; In Between Ring fingers
      cd16773
      Location:53 → 106
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:214 → 246
      IBR; IBR domain, a half RING-finger domain

    21. NM_001349227.2 → NP_001336156.1  E3 ubiquitin-protein ligase ARIH2 isoform h

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22) encodes isoform h.
      Source sequence(s)
      AC134028, AC137630
      UniProtKB/TrEMBL
      Q59HA2
      Conserved Domains (1) summary
      smart00647
      Location:25 → 87
      IBR; In Between Ring fingers

    22. NM_001349228.2 → NP_001336157.1  E3 ubiquitin-protein ligase ARIH2 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 24 and 25, encodes isoform i.
      Source sequence(s)
      AC134028
      UniProtKB/TrEMBL
      C9JCL4

    23. NM_001349229.2 → NP_001336158.1  E3 ubiquitin-protein ligase ARIH2 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 23 and 25, encodes isoform i.
      Source sequence(s)
      AC134028
      UniProtKB/TrEMBL
      C9JCL4

    24. NM_001349230.2 → NP_001336159.1  E3 ubiquitin-protein ligase ARIH2 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 23 and 24, encodes isoform i.
      Source sequence(s)
      AC134028
      UniProtKB/TrEMBL
      C9JCL4
      Related
      ENSP00000404838.1, ENST00000449729.5

    25. NM_006321.4 → NP_006312.1  E3 ubiquitin-protein ligase ARIH2 isoform a

      See identical proteins and their annotated locations for NP_006312.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2), as well as variants 1, 4, 5, and 6, encodes isoform a.
      Source sequence(s)
      AC137630, AL110187, BC000422, BG476221
      Consensus CDS
      CCDS2780.1
      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
      Related
      ENSP00000348769.4, ENST00000356401.9
      Conserved Domains (3) summary
      smart00647
      Location:208 → 270
      IBR; In Between Ring fingers
      cd16773
      Location:137 → 190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:298 → 330
      IBR; IBR domain, a half RING-finger domain

    RNA

    1. NR_146082.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC134028, AC137630

    2. NR_146083.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC134028, AC137630

    3. NR_146084.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC134028, AC137630

    4. NR_146085.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC134028, AC137630

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      48918842..48986382
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024453309.2 → XP_024309077.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q53ET9, Q6IBL8
      Conserved Domains (3) summary
      smart00647
      Location:208 → 270
      IBR; In Between Ring fingers
      cd16773
      Location:137 → 190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)
      pfam01485
      Location:298 → 330
      IBR; IBR domain, a half RING-finger domain

    2. XM_047447278.1 → XP_047303234.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

    3. XM_011533271.2 → XP_011531573.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      See identical proteins and their annotated locations for XP_011531573.1

      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:136 → 198
      IBR; In Between Ring fingers
      cd16773
      Location:65 → 118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

    4. XM_011533268.2 → XP_011531570.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

      See identical proteins and their annotated locations for XP_011531570.1

      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:208 → 270
      IBR; In Between Ring fingers
      cd16773
      Location:137 → 190
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

    5. XM_047447283.1 → XP_047303239.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

    6. XM_017005534.2 → XP_016861023.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:136 → 198
      IBR; In Between Ring fingers
      cd16773
      Location:65 → 118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

    7. XM_047447284.1 → XP_047303240.1  E3 ubiquitin-protein ligase ARIH2 isoform X5

    8. XM_024453311.2 → XP_024309079.1  E3 ubiquitin-protein ligase ARIH2 isoform X6

      UniProtKB/TrEMBL
      Q59HA2
      Conserved Domains (2) summary
      smart00647
      Location:66 → 128
      IBR; In Between Ring fingers
      cd16773
      Location:1 → 48
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

    9. XM_047447267.1 → XP_047303223.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    10. XM_047447265.1 → XP_047303221.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    11. XM_017005535.2 → XP_016861024.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

      UniProtKB/TrEMBL
      Q53ET9
      Conserved Domains (2) summary
      smart00647
      Location:136 → 198
      IBR; In Between Ring fingers
      cd16773
      Location:65 → 118
      RING-HC_RBR_TRIAD1; RING finger, HC subclass, found in two RING fingers and DRIL [double RING finger linked] 1 (TRIAD1)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      48947848..49014431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344930.1 → XP_054200905.1  E3 ubiquitin-protein ligase ARIH2 isoform X2

      UniProtKB/Swiss-Prot
      O95376, Q9HBZ6, Q9UEM9
      UniProtKB/TrEMBL
      A0A024R2S5, Q6IBL8

    2. XM_054344934.1 → XP_054200909.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

    3. XM_054344933.1 → XP_054200908.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

    4. XM_054344928.1 → XP_054200903.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    5. XM_054344935.1 → XP_054200910.1  E3 ubiquitin-protein ligase ARIH2 isoform X4

    6. XM_054344931.1 → XP_054200906.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

    7. XM_054344936.1 → XP_054200911.1  E3 ubiquitin-protein ligase ARIH2 isoform X5

    8. XM_054344937.1 → XP_054200912.1  E3 ubiquitin-protein ligase ARIH2 isoform X6

    9. XM_054344927.1 → XP_054200902.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    10. XM_054344929.1 → XP_054200904.1  E3 ubiquitin-protein ligase ARIH2 isoform X1

    11. XM_054344932.1 → XP_054200907.1  E3 ubiquitin-protein ligase ARIH2 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O95376.1 GenPept UniProtKB/Swiss-Prot:O95376

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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