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    PIKFYVE phosphoinositide kinase, FYVE-type zinc finger containing [ Homo sapiens (human) ]

    Gene ID: 200576, updated on 10-Dec-2024

    Summary

    Official Symbol
    PIKFYVEprovided by HGNC
    Official Full Name
    phosphoinositide kinase, FYVE-type zinc finger containingprovided by HGNC
    Primary source
    HGNC:HGNC:23785
    See related
    Ensembl:ENSG00000115020 MIM:609414; AllianceGenome:HGNC:23785
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CFD; FAB1; HEL37; PIP5K; PIP5K3; ZFYVE29
    Summary
    Phosphorylated derivatives of phosphatidylinositol (PtdIns) regulate cytoskeletal functions, membrane trafficking, and receptor signaling by recruiting protein complexes to cell- and endosomal-membranes. Humans have multiple PtdIns proteins that differ by the degree and position of phosphorylation of the inositol ring. This gene encodes an enzyme (PIKfyve; also known as phosphatidylinositol-3-phosphate 5-kinase type III or PIPKIII) that phosphorylates the D-5 position in PtdIns and phosphatidylinositol-3-phosphate (PtdIns3P) to make PtdIns5P and PtdIns(3,5)biphosphate. The D-5 position also can be phosphorylated by type I PtdIns4P-5-kinases (PIP5Ks) that are encoded by distinct genes and preferentially phosphorylate D-4 phosphorylated PtdIns. In contrast, PIKfyve preferentially phosphorylates D-3 phosphorylated PtdIns. In addition to being a lipid kinase, PIKfyve also has protein kinase activity. PIKfyve regulates endomembrane homeostasis and plays a role in the biogenesis of endosome carrier vesicles from early endosomes. The protein plays a key role in cell entry of ebola virus and SARS-CoV-2 by endocytosis Mutations in this gene cause corneal fleck dystrophy (CFD); an autosomal dominant disorder characterized by numerous small white flecks present in all layers of the corneal stroma. Histologically, these flecks appear to be keratocytes distended with lipid and mucopolysaccharide filled intracytoplasmic vacuoles. [provided by RefSeq, Jul 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in SARS-CoV-2 infection.
    Expression
    Ubiquitous expression in bone marrow (RPKM 9.7), lymph node (RPKM 8.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PIKFYVE in Genome Data Viewer
    Location:
    2q34
    Exon count:
    43
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (208266056..208358746)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (208744537..208838556)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (209130979..209223470)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12288 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:209119503-209120029 Neighboring gene isocitrate dehydrogenase (NADP(+)) 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17051 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12289 Neighboring gene IDH1 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:209134199-209134700 Neighboring gene MYL6B pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17052 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12290 Neighboring gene ARPC1B pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:209241536-209242336 Neighboring gene parathyroid hormone 2 receptor Neighboring gene uncharacterized LOC105373855

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Overexpression of phosphatidylinositol 4 phosphate 5-kinase (PIP5K) suppresses HIV-1 Tat-mediated inhibition of growth hormone secretion from cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ37746, KIAA0981, MGC40423

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-3-phosphate 5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 1-phosphatidylinositol-4-phosphate 5-kinase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables 1-phosphatidylinositol-5-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 1-phosphatidylinositol-5-kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 1-phosphatidylinositol-5-kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in melanosome organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in melanosome organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in myelin assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neutrophil chemotaxis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neutrophil chemotaxis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in peptidyl-serine autophosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phagosome maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phagosome-lysosome fusion IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phagosome-lysosome fusion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylinositol 5-phosphate metabolic process IC
    Inferred by Curator
    more info
    PubMed 
    involved_in phosphatidylinositol 5-phosphate metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
     
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    NOT involved_in receptor-mediated endocytosis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in receptor-mediated endocytosis of virus by host cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of autophagosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of reactive oxygen species biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of reactive oxygen species biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retrograde transport, endosome to Golgi IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane TAS
    Traceable Author Statement
    more info
     
    located_in cell-cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoplasmic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in early endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in early endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome membrane TAS
    Traceable Author Statement
    more info
     
    located_in membrane raft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in phagocytic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in vesicle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    1-phosphatidylinositol 3-phosphate 5-kinase
    Names
    PIPkin-III
    epididymis luminal protein 37
    phosphatidylinositol 3-phosphate 5-kinase type III
    phosphatidylinositol-3-phosphate/phosphatidylinositol 5-kinase, type III
    phosphoinositide kinase, FYVE finger containing
    serine-protein kinase PIKFYVE
    type III PIP kinase
    zinc finger, FYVE domain containing 29
    NP_001171471.1
    NP_055855.2
    NP_689884.1
    XP_011509080.1
    XP_011509081.1
    XP_011509082.1
    XP_011509083.1
    XP_011509084.1
    XP_011509085.1
    XP_011509086.1
    XP_011509087.1
    XP_011509088.1
    XP_011509089.1
    XP_011509090.1
    XP_011509091.1
    XP_011509094.1
    XP_016859057.1
    XP_016859058.1
    XP_016859059.1
    XP_016859060.1
    XP_016859063.1
    XP_047299623.1
    XP_047299626.1
    XP_047299627.1
    XP_047299628.1
    XP_047299629.1
    XP_047299630.1
    XP_047299632.1
    XP_047299633.1
    XP_047299635.1
    XP_047299636.1
    XP_047299637.1
    XP_047299638.1
    XP_047299642.1
    XP_047299643.1
    XP_047299645.1
    XP_047299646.1
    XP_047299651.1
    XP_047299652.1
    XP_047299654.1
    XP_054196941.1
    XP_054196942.1
    XP_054196943.1
    XP_054196944.1
    XP_054196945.1
    XP_054196946.1
    XP_054196947.1
    XP_054196948.1
    XP_054196949.1
    XP_054196950.1
    XP_054196951.1
    XP_054196952.1
    XP_054196953.1
    XP_054196954.1
    XP_054196955.1
    XP_054196956.1
    XP_054196957.1
    XP_054196958.1
    XP_054196959.1
    XP_054196960.1
    XP_054196961.1
    XP_054196962.1
    XP_054196963.1
    XP_054196964.1
    XP_054196965.1
    XP_054196966.1
    XP_054196967.1
    XP_054196968.1
    XP_054196969.1
    XP_054196970.1
    XP_054196971.1
    XP_054196972.1
    XP_054196973.1
    XP_054196974.1
    XP_054196975.1
    XP_054196976.1
    XP_054196977.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021188.2 RefSeqGene

      Range
      5201..97692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178000.2NP_001171471.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform 4

      See identical proteins and their annotated locations for NP_001171471.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks all of the 3' coding region and UTR, compared to variant 2. The encoded protein (isoform 4) has an identical N-terminus but a short novel C-terminus, compared to isoform 2.
      Source sequence(s)
      AC016697, BC032389, BC125053
      Consensus CDS
      CCDS54431.1
      UniProtKB/Swiss-Prot
      Q9Y2I7
      Related
      ENSP00000384356.1, ENST00000407449.5
      Conserved Domains (2) summary
      cd04448
      Location:357438
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:154215
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    2. NM_015040.4NP_055855.2  1-phosphatidylinositol 3-phosphate 5-kinase isoform 2

      See identical proteins and their annotated locations for NP_055855.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2).
      Source sequence(s)
      AC012362, AC016697
      Consensus CDS
      CCDS2382.1
      UniProtKB/Swiss-Prot
      Q08AR7, Q08AR8, Q53ST3, Q53T36, Q8N5H0, Q8NB67, Q9Y2I7
      Related
      ENSP00000264380.4, ENST00000264380.9
      Conserved Domains (4) summary
      cd00139
      Location:17722085
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:617877
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:357438
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:154215
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    3. NM_152671.4NP_689884.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform 3

      See identical proteins and their annotated locations for NP_689884.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two in-frame exons in the 5' coding region and all of the 3' coding region and UTR, compared to variant 2. The encoded protein (isoform 3) has a shorter N-terminus and a short novel C-terminus, compared to isoform 2.
      Source sequence(s)
      AC016697, BC032389
      Consensus CDS
      CCDS33368.1
      UniProtKB/Swiss-Prot
      Q9Y2I7
      Related
      ENSP00000376038.3, ENST00000392202.7
      Conserved Domains (1) summary
      cd04448
      Location:260341
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      208266056..208358746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510779.3XP_011509081.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

      See identical proteins and their annotated locations for XP_011509081.1

      Conserved Domains (4) summary
      cd00139
      Location:17842097
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:629889
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    2. XM_047443667.1XP_047299623.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

      UniProtKB/Swiss-Prot
      Q08AR7, Q08AR8, Q53ST3, Q53T36, Q8N5H0, Q8NB67, Q9Y2I7
    3. XM_047443672.1XP_047299628.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X11

    4. XM_047443674.1XP_047299630.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X16

    5. XM_011510778.4XP_011509080.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

      See identical proteins and their annotated locations for XP_011509080.1

      Conserved Domains (4) summary
      cd00139
      Location:17842097
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:629889
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    6. XM_011510782.4XP_011509084.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X6

      Conserved Domains (4) summary
      cd00139
      Location:17352042
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:629889
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    7. XM_011510783.4XP_011509085.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X7

      Conserved Domains (4) summary
      cd00139
      Location:17282041
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:573833
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    8. XM_011510781.4XP_011509083.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

      Conserved Domains (4) summary
      cd00139
      Location:17782091
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:623883
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    9. XM_011510785.4XP_011509087.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X9

      Conserved Domains (4) summary
      cd00139
      Location:17222035
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:567827
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    10. XM_011510786.4XP_011509088.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X14

      Conserved Domains (3) summary
      cd00139
      Location:16872000
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:532792
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:272353
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    11. XM_047443680.1XP_047299636.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X20

    12. XM_011510780.3XP_011509082.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

      Conserved Domains (4) summary
      cd00139
      Location:17832096
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:628888
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:368449
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:165226
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    13. XM_011510784.3XP_011509086.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X8

      Conserved Domains (4) summary
      cd00139
      Location:17272040
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:572832
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:368449
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:165226
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    14. XM_011510787.2XP_011509089.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X15

      Conserved Domains (3) summary
      cd00139
      Location:16861999
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:531791
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:271352
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    15. XM_047443670.1XP_047299626.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X10

    16. XM_047443671.1XP_047299627.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X11

    17. XM_047443677.1XP_047299633.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X18

    18. XM_017003568.2XP_016859057.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X5

    19. XM_047443673.1XP_047299629.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X12

    20. XM_017003569.2XP_016859058.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X13

    21. XM_047443679.1XP_047299635.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X19

    22. XM_011510788.2XP_011509090.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X16

      Conserved Domains (3) summary
      cd00139
      Location:16751988
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:520780
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:260341
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    23. XM_047443681.1XP_047299637.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X22

    24. XM_017003570.2XP_016859059.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X23

    25. XM_047443690.1XP_047299646.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X29

    26. XM_047443676.1XP_047299632.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X17

    27. XM_047443686.1XP_047299642.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X25

    28. XM_047443687.1XP_047299643.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X26

    29. XM_047443696.1XP_047299652.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X31

    30. XM_011510789.3XP_011509091.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X21

      Conserved Domains (3) summary
      cd00139
      Location:16251938
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:470730
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:210291
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    31. XM_047443689.1XP_047299645.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X27

    32. XM_017003571.2XP_016859060.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X28

    33. XM_047443682.1XP_047299638.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X24

    34. XM_047443695.1XP_047299651.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X30

    35. XM_011510792.4XP_011509094.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X33

      UniProtKB/TrEMBL
      E9PDH4
      Related
      ENSP00000405736.1, ENST00000452564.1
      Conserved Domains (3) summary
      cd03334
      Location:629889
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:369450
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
      cd15725
      Location:166227
      FYVE_PIKfyve_Fab1; FYVE domain found in metazoan PIKfyve, fungal and plant Fab1, and similar proteins
    36. XM_017003574.2XP_016859063.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X32

      Conserved Domains (3) summary
      cd00139
      Location:14531766
      PIPKc; Phosphatidylinositol phosphate kinases (PIPK) catalyze the phosphorylation of phosphatidylinositol phosphate on the fourth or fifth hydroxyl of the inositol ring, to form phosphatidylinositol bisphosphate. CD alignment includes type II ...
      cd03334
      Location:298558
      Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
      cd04448
      Location:38119
      DEP_PIKfyve; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in fungal RhoGEF (GDP/GTP exchange factor) PIKfyve-like proteins. PIKfyve contains N-terminal Fyve finger and DEP domains, a central chaperonin-like domain and a C-terminal PIPK (phosphatidylinositol ...
    37. XM_047443698.1XP_047299654.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X32

    RNA

    1. XR_007070607.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      208744537..208838556
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340970.1XP_054196945.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X4

      UniProtKB/TrEMBL
      V9HWG4
    2. XM_054340978.1XP_054196953.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X11

    3. XM_054340967.1XP_054196942.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    4. XM_054340984.1XP_054196959.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X16

    5. XM_054340966.1XP_054196941.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X1

    6. XM_054340972.1XP_054196947.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X6

    7. XM_054340973.1XP_054196948.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X7

    8. XM_054340969.1XP_054196944.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X3

    9. XM_054340975.1XP_054196950.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X9

    10. XM_054340981.1XP_054196956.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X14

    11. XM_054340988.1XP_054196963.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X20

    12. XM_054340968.1XP_054196943.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X2

    13. XM_054340974.1XP_054196949.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X8

    14. XM_054340982.1XP_054196957.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X15

    15. XM_054340976.1XP_054196951.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X10

    16. XM_054340977.1XP_054196952.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X11

    17. XM_054340986.1XP_054196961.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X18

    18. XM_054340971.1XP_054196946.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X5

    19. XM_054340979.1XP_054196954.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X12

    20. XM_054340980.1XP_054196955.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X13

    21. XM_054340987.1XP_054196962.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X19

    22. XM_054340983.1XP_054196958.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X16

    23. XM_054340990.1XP_054196965.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X22

    24. XM_054340991.1XP_054196966.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X23

    25. XM_054340997.1XP_054196972.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X29

    26. XM_054340985.1XP_054196960.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X17

    27. XM_054340993.1XP_054196968.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X25

    28. XM_054340994.1XP_054196969.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X26

    29. XM_054340999.1XP_054196974.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X31

    30. XM_054340989.1XP_054196964.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X21

    31. XM_054340995.1XP_054196970.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X27

    32. XM_054340996.1XP_054196971.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X28

    33. XM_054340992.1XP_054196967.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X24

    34. XM_054340998.1XP_054196973.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X30

    35. XM_054341002.1XP_054196977.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X33

      UniProtKB/TrEMBL
      E9PDH4
    36. XM_054341001.1XP_054196976.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X32

    37. XM_054341000.1XP_054196975.1  1-phosphatidylinositol 3-phosphate 5-kinase isoform X32

    RNA

    1. XR_008486304.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001002881.1: Suppressed sequence

      Description
      NM_001002881.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.