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    PLPPR3 phospholipid phosphatase related 3 [ Homo sapiens (human) ]

    Gene ID: 79948, updated on 10-Dec-2024

    Summary

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    Official Symbol
    PLPPR3provided by HGNC
    Official Full Name
    phospholipid phosphatase related 3provided by HGNC
    Primary source
    HGNC:HGNC:23497
    See related
    Ensembl:ENSG00000129951 MIM:610391; AllianceGenome:HGNC:23497
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LPR3; PRG2; LPPR3; PRG-2
    Summary
    The proteins in the lipid phosphate phosphatase (LPP) family, including PRG2, are integral membrane proteins that modulate bioactive lipid phosphates including phosphatidate, lysophosphatidate, and sphingosine-1-phosphate in the context of cell migration, neurite retraction, and mitogenesis (Brauer et al., 2003 [PubMed 12730698]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in bone marrow (RPKM 2.7), brain (RPKM 2.5) and 2 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PLPPR3 in Genome Data Viewer
    Location:
    19p13.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (812488..823797, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (766962..778213, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (812488..821955, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:782349-782922 Neighboring gene long intergenic non-protein coding RNA 1836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:787176-787746 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:787747-788315 Neighboring gene CRISPRi-validated cis-regulatory element chr19.128 Neighboring gene CRISPRi-validated cis-regulatory element chr19.129 Neighboring gene hESC enhancers GRCh37_chr19:796571-797206 and GRCh37_chr19:797405-798290 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:798291-799174 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:803235-803757 Neighboring gene polypyrimidine tract binding protein 1 Neighboring gene microRNA 4745 Neighboring gene microRNA 3187 Neighboring gene azurocidin 1 Neighboring gene proteinase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting. Bräuer AU, et al. Nat Neurosci, 2003 Jun. PMID 12730698
    2. Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration. Tracy TE, et al. Cell, 2022 Feb 17. PMID 35063084, Free PMC Article
    3. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article
    4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Wiemann S, et al. Genome Res, 2001 Mar. PMID 11230166, Free PMC Article
    5. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phospholipid dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phospholipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    phospholipid phosphatase-related protein type 3
    Names
    PAP-2-like protein 2
    inactive phospholipid phosphatase PLPPR3
    lipid phosphate phosphatase-related protein type 3
    plasticity-related gene 2 protein
    NP_001257295.1
    NP_079164.1
    XP_011526619.1
    XP_054178182.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270366.2 → NP_001257295.1  phospholipid phosphatase-related protein type 3 isoform 2

      See identical proteins and their annotated locations for NP_001257295.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate segment in the coding region, compared to variant 1. The resulting isoform (2) lacks an internal region compared to isoform 1.
      Source sequence(s)
      AC004799, AL136596, AY436785, BC012339
      Consensus CDS
      CCDS58636.1
      UniProtKB/Swiss-Prot
      Q6T4P5, Q86XQ4, Q96EH1, Q9BQF9, Q9HAJ4
      UniProtKB/TrEMBL
      H0YBY4
      Related
      ENSP00000430297.1, ENST00000520876.8
      Conserved Domains (1) summary
      cd03384
      Location:129 → 278
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    2. NM_024888.3 → NP_079164.1  phospholipid phosphatase-related protein type 3 isoform 1

      See identical proteins and their annotated locations for NP_079164.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1)
      Source sequence(s)
      AC004799, AC006273, AL136596, BC012339
      Consensus CDS
      CCDS12043.1
      UniProtKB/TrEMBL
      H0YBY4
      Related
      ENSP00000352962.2, ENST00000359894.6
      Conserved Domains (1) summary
      cd03384
      Location:129 → 306
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      812488..823797 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528317.4 → XP_011526619.1  phospholipid phosphatase-related protein type 3 isoform X1

      See identical proteins and their annotated locations for XP_011526619.1

      UniProtKB/TrEMBL
      H0YBY4
      Conserved Domains (1) summary
      cd03384
      Location:129 → 306
      PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      766962..778213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322207.1 → XP_054178182.1  phospholipid phosphatase-related protein type 3 isoform X1

      UniProtKB/TrEMBL
      H0YBY4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6T4P5.1 GenPept UniProtKB/Swiss-Prot:Q6T4P5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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