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    ACBD4 acyl-CoA binding domain containing 4 [ Homo sapiens (human) ]

    Gene ID: 79777, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ACBD4provided by HGNC
    Official Full Name
    acyl-CoA binding domain containing 4provided by HGNC
    Primary source
    HGNC:HGNC:23337
    See related
    Ensembl:ENSG00000181513 MIM:619968; AllianceGenome:HGNC:23337
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HMFT0700
    Summary
    This gene encodes a member of the acyl-coenzyme A binding domain containing protein family. All family members contain the conserved acyl-Coenzyme A binding domain, which binds acyl-CoA thiol esters. They are thought to play roles in acyl-CoA dependent lipid metabolism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
    Expression
    Ubiquitous expression in liver (RPKM 7.3), duodenum (RPKM 7.0) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ACBD4 in Genome Data Viewer
    Location:
    17q21.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (45131597..45144176)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (45985481..45998057)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (43209986..43221543)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43138457-43139448 Neighboring gene N-myristoyltransferase 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr17:43168092-43168593 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43175496-43175996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43175997-43176497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12273 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43180894-43181394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43184227-43184728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43189298-43190163 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43190164-43191028 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:43191895-43192759 Neighboring gene phospholipase C delta 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43198136-43198673 Neighboring gene microRNA 6784 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12274 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43220320-43221042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43221043-43221764 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43222487-43223207 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43224945-43225827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12275 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12277 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:43226945-43227500 Neighboring gene HEXIM2 antisense RNA 1 Neighboring gene HEXIM P-TEFb complex subunit 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43237877-43238492 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43238493-43239108 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:43239109-43239724 Neighboring gene HEXIM P-TEFb complex subunit 2 Neighboring gene HEXIM2 antisense RNA 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome associations. Costello JL, et al. Cell Cycle, 2017 Jun 3. PMID 28463579, Free PMC Article
    2. Differential roles for ACBD4 and ACBD5 in peroxisome-ER interactions and lipid metabolism. Costello JL, et al. J Biol Chem, 2023 Aug. PMID 37414147, Free PMC Article
    3. Discovery and replication of novel blood pressure genetic loci in the Women's Genome Health Study. Ho JE, et al. J Hypertens, 2011 Jan. PMID 21045733, Free PMC Article
    4. Genome-wide association study identifies eight loci associated with blood pressure. Newton-Cheh C, et al. Nat Genet, 2009 Jun. PMID 19430483, Free PMC Article
    5. Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas. Yamada S, et al. Oncogene, 2004 Aug 5. PMID 15221005

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies eight loci associated with blood pressure.
    EBI GWAS Catalog
    Hundreds of variants clustered in genomic loci and biological pathways affect human height.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
    EBI GWAS Catalog
    The genetic architecture of economic and political preferences.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13322, FLJ90623

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fatty-acyl-CoA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    acyl-CoA-binding domain-containing protein 4
    Names
    acyl-Coenzyme A binding domain containing 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135705.3 → NP_001129177.1  acyl-CoA-binding domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_001129177.1

      Status: REVIEWED

      Source sequence(s)
      BC029164, BF514946, DC393065
      Consensus CDS
      CCDS42348.1
      UniProtKB/TrEMBL
      A0A0S2Z5Q0
      Related
      ENSP00000314440.8, ENST00000321854.13
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    2. NM_001135706.3 → NP_001129178.1  acyl-CoA-binding domain-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_001129178.1

      Status: REVIEWED

      Source sequence(s)
      AK296167, BC041143
      Consensus CDS
      CCDS45710.1
      UniProtKB/TrEMBL
      A0A0S2Z5Y4, B4DJP3, B7ZAP4
      Related
      ENSP00000465484.1, ENST00000586346.5
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    3. NM_001135707.3 → NP_001129179.1  acyl-CoA-binding domain-containing protein 4 isoform 3

      See identical proteins and their annotated locations for NP_001129179.1

      Status: REVIEWED

      Source sequence(s)
      AC142472, AK075104, BC041143, CN293965, DC393065
      Consensus CDS
      CCDS45711.1
      UniProtKB/Swiss-Prot
      D3DX64, Q8IUT1, Q8NC06, Q9H8Q4
      Related
      ENSP00000366154.3, ENST00000376955.8
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    4. NM_001321352.2 → NP_001308281.1  acyl-CoA-binding domain-containing protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      BC041143, DB128538
      Consensus CDS
      CCDS45710.1
      UniProtKB/TrEMBL
      A0A0S2Z5Y4, B4DJP3, B7ZAP4
      Related
      ENSP00000465610.1, ENST00000591859.5
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    5. NM_001321353.2 → NP_001308282.1  acyl-CoA-binding domain-containing protein 4 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC142472, BC041143, DB128538
      Consensus CDS
      CCDS45710.1
      UniProtKB/TrEMBL
      A0A0S2Z5Y4, B4DJP3, B7ZAP4
      Related
      ENSP00000405969.1, ENST00000431281.5
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    6. NM_001378111.1 → NP_001365040.1  acyl-CoA-binding domain-containing protein 4 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC142472
      UniProtKB/TrEMBL
      B4DJP3
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    7. NM_001378112.1 → NP_001365041.1  acyl-CoA-binding domain-containing protein 4 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC142472

    8. NM_001411125.1 → NP_001398054.1  acyl-CoA-binding domain-containing protein 4 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC142472
      Consensus CDS
      CCDS92338.1
      UniProtKB/TrEMBL
      K7EM05

    9. NM_024722.4 → NP_078998.1  acyl-CoA-binding domain-containing protein 4 isoform 2

      See identical proteins and their annotated locations for NP_078998.1

      Status: REVIEWED

      Source sequence(s)
      AK023384, BC041143, DC421936
      Consensus CDS
      CCDS42348.1
      UniProtKB/TrEMBL
      A0A0S2Z5Q0
      Related
      ENSP00000381367.2, ENST00000398322.7
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      45131597..45144176
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436765.1 → XP_047292721.1  acyl-CoA-binding domain-containing protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A0S2Z5Q0

    2. XM_017025092.3 → XP_016880581.1  acyl-CoA-binding domain-containing protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A0S2Z5Q0
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    3. XM_047436763.1 → XP_047292719.1  acyl-CoA-binding domain-containing protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A0S2Z5Q0

    4. XM_017025084.2 → XP_016880573.1  acyl-CoA-binding domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      B4DJP3, B7ZAP4
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    5. XM_017025095.2 → XP_016880584.1  acyl-CoA-binding domain-containing protein 4 isoform X16

      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    6. XM_047436766.1 → XP_047292722.1  acyl-CoA-binding domain-containing protein 4 isoform X12

      UniProtKB/TrEMBL
      B4DJP3

    7. XM_047436768.1 → XP_047292724.1  acyl-CoA-binding domain-containing protein 4 isoform X14

      UniProtKB/TrEMBL
      B4DJP3

    8. XM_017025087.2 → XP_016880576.1  acyl-CoA-binding domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      B4DJP3, B7ZAP4
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    9. XM_047436767.1 → XP_047292723.1  acyl-CoA-binding domain-containing protein 4 isoform X13

      UniProtKB/TrEMBL
      B4DJP3

    10. XM_047436769.1 → XP_047292725.1  acyl-CoA-binding domain-containing protein 4 isoform X15

      UniProtKB/TrEMBL
      B4DJP3

    11. XM_017025088.2 → XP_016880577.1  acyl-CoA-binding domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z5Y4, B4DJP3, B7ZAP4
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    12. XM_017025097.2 → XP_016880586.1  acyl-CoA-binding domain-containing protein 4 isoform X18

      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    13. XM_017025090.2 → XP_016880579.1  acyl-CoA-binding domain-containing protein 4 isoform X8

    14. XM_017025096.2 → XP_016880585.1  acyl-CoA-binding domain-containing protein 4 isoform X17

    15. XM_017025089.3 → XP_016880578.1  acyl-CoA-binding domain-containing protein 4 isoform X4

    16. XM_047436761.1 → XP_047292717.1  acyl-CoA-binding domain-containing protein 4 isoform X6

    17. XM_006722085.3 → XP_006722148.1  acyl-CoA-binding domain-containing protein 4 isoform X9

      UniProtKB/TrEMBL
      A0A0S2Z5W7
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    18. XM_047436760.1 → XP_047292716.1  acyl-CoA-binding domain-containing protein 4 isoform X5

    19. XM_047436762.1 → XP_047292718.1  acyl-CoA-binding domain-containing protein 4 isoform X7

    20. XM_017025099.2 → XP_016880588.1  acyl-CoA-binding domain-containing protein 4 isoform X19

      UniProtKB/TrEMBL
      K7EM05
      Related
      ENSP00000466305.1, ENST00000592162.5
      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    21. XM_047436764.1 → XP_047292720.1  acyl-CoA-binding domain-containing protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A0S2Z5Q0

    22. XM_017025093.2 → XP_016880582.1  acyl-CoA-binding domain-containing protein 4 isoform X11

      UniProtKB/TrEMBL
      B4DJP3

    23. XM_017025100.2 → XP_016880589.1  acyl-CoA-binding domain-containing protein 4 isoform X20

    24. XM_011525259.3 → XP_011523561.1  acyl-CoA-binding domain-containing protein 4 isoform X21

      Conserved Domains (2) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein
      cl00464
      Location:103 → 199
      URO-D_CIMS_like; The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases. ...

    25. XM_017025101.3 → XP_016880590.1  acyl-CoA-binding domain-containing protein 4 isoform X22

    26. XM_011525261.3 → XP_011523563.1  acyl-CoA-binding domain-containing protein 4 isoform X23

      Conserved Domains (1) summary
      pfam00887
      Location:13 → 93
      ACBP; Acyl CoA binding protein

    27. XM_047436772.1 → XP_047292728.1  acyl-CoA-binding domain-containing protein 4 isoform X23

    28. XM_047436770.1 → XP_047292726.1  acyl-CoA-binding domain-containing protein 4 isoform X18

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      45985481..45998057
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054317246.1 → XP_054173221.1  acyl-CoA-binding domain-containing protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A0S2Z5Q0

    2. XM_054317247.1 → XP_054173222.1  acyl-CoA-binding domain-containing protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A0S2Z5Q0

    3. XM_054317243.1 → XP_054173218.1  acyl-CoA-binding domain-containing protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A0S2Z5Q0

    4. XM_054317233.1 → XP_054173208.1  acyl-CoA-binding domain-containing protein 4 isoform X1

      UniProtKB/TrEMBL
      B4DJP3, B7ZAP4

    5. XM_054317253.1 → XP_054173228.1  acyl-CoA-binding domain-containing protein 4 isoform X16

    6. XM_054317249.1 → XP_054173224.1  acyl-CoA-binding domain-containing protein 4 isoform X12

      UniProtKB/TrEMBL
      B4DJP3

    7. XM_054317251.1 → XP_054173226.1  acyl-CoA-binding domain-containing protein 4 isoform X14

      UniProtKB/TrEMBL
      B4DJP3

    8. XM_054317234.1 → XP_054173209.1  acyl-CoA-binding domain-containing protein 4 isoform X2

      UniProtKB/TrEMBL
      B4DJP3, B7ZAP4

    9. XM_054317250.1 → XP_054173225.1  acyl-CoA-binding domain-containing protein 4 isoform X13

      UniProtKB/TrEMBL
      B4DJP3

    10. XM_054317252.1 → XP_054173227.1  acyl-CoA-binding domain-containing protein 4 isoform X15

      UniProtKB/TrEMBL
      B4DJP3

    11. XM_054317235.1 → XP_054173210.1  acyl-CoA-binding domain-containing protein 4 isoform X3

      UniProtKB/TrEMBL
      A0A0S2Z5Y4, B4DJP3, B7ZAP4

    12. XM_054317255.1 → XP_054173230.1  acyl-CoA-binding domain-containing protein 4 isoform X18

    13. XM_054317240.1 → XP_054173215.1  acyl-CoA-binding domain-containing protein 4 isoform X8

    14. XM_054317254.1 → XP_054173229.1  acyl-CoA-binding domain-containing protein 4 isoform X17

    15. XM_054317236.1 → XP_054173211.1  acyl-CoA-binding domain-containing protein 4 isoform X4

    16. XM_054317238.1 → XP_054173213.1  acyl-CoA-binding domain-containing protein 4 isoform X6

    17. XM_054317241.1 → XP_054173216.1  acyl-CoA-binding domain-containing protein 4 isoform X9

      UniProtKB/TrEMBL
      A0A0S2Z5W7

    18. XM_054317237.1 → XP_054173212.1  acyl-CoA-binding domain-containing protein 4 isoform X5

    19. XM_054317239.1 → XP_054173214.1  acyl-CoA-binding domain-containing protein 4 isoform X7

    20. XM_054317242.1 → XP_054173217.1  acyl-CoA-binding domain-containing protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A0S2Z5Q0

    21. XM_054317257.1 → XP_054173232.1  acyl-CoA-binding domain-containing protein 4 isoform X19

      UniProtKB/TrEMBL
      K7EM05

    22. XM_054317244.1 → XP_054173219.1  acyl-CoA-binding domain-containing protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A0S2Z5Q0

    23. XM_054317248.1 → XP_054173223.1  acyl-CoA-binding domain-containing protein 4 isoform X11

      UniProtKB/TrEMBL
      B4DJP3

    24. XM_054317260.1 → XP_054173235.1  acyl-CoA-binding domain-containing protein 4 isoform X21

    25. XM_054317262.1 → XP_054173237.1  acyl-CoA-binding domain-containing protein 4 isoform X23

    26. XM_054317264.1 → XP_054173239.1  acyl-CoA-binding domain-containing protein 4 isoform X23

    27. XM_054317259.1 → XP_054173234.1  acyl-CoA-binding domain-containing protein 4 isoform X20

    28. XM_054317261.1 → XP_054173236.1  acyl-CoA-binding domain-containing protein 4 isoform X22

    29. XM_054317245.1 → XP_054173220.1  acyl-CoA-binding domain-containing protein 4 isoform X10

      UniProtKB/TrEMBL
      A0A0S2Z5Q0

    30. XM_054317256.1 → XP_054173231.1  acyl-CoA-binding domain-containing protein 4 isoform X18

    31. XM_054317258.1 → XP_054173233.1  acyl-CoA-binding domain-containing protein 4 isoform X19

      UniProtKB/TrEMBL
      K7EM05

    32. XM_054317263.1 → XP_054173238.1  acyl-CoA-binding domain-containing protein 4 isoform X23

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001135704.1: Suppressed sequence

      Description
      NM_001135704.1: This RefSeq was removed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NC06.2 GenPept UniProtKB/Swiss-Prot:Q8NC06

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