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    UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 [ Homo sapiens (human) ]

    Gene ID: 55757, updated on 9-Dec-2024

    Summary

    Official Symbol
    UGGT2provided by HGNC
    Official Full Name
    UDP-glucose glycoprotein glucosyltransferase 2provided by HGNC
    Primary source
    HGNC:HGNC:15664
    See related
    Ensembl:ENSG00000102595 MIM:605898; AllianceGenome:HGNC:15664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    UGT2; HUGT2; UGCGL2
    Summary
    UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
    Expression
    Ubiquitous expression in thyroid (RPKM 5.5), testis (RPKM 4.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See UGGT2 in Genome Data Viewer
    Location:
    13q32.1
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (95801580..96053401, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (95006150..95257608, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (96453834..96705655, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5448 Neighboring gene Sharpr-MPRA regulatory region 4273 Neighboring gene MT-ND6 pseudogene 18 Neighboring gene MT-CYB pseudogene 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C3 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 24 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96558977-96559478 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:96606253-96607155 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96611347-96611848 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96611849-96612348 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96666836-96667336 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:96693792-96694381 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:96705417-96705916 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96741684-96742184 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:96742185-96742685 Neighboring gene heparan sulfate 6-O-sulfotransferase 3 Neighboring gene RNA, 7SL, cytoplasmic 164, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr13:96947250-96948184 Neighboring gene microRNA 4501

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10873, FLJ11485, MGC87276, MGC117360, MGC150689

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables UDP-glucose:glycoprotein glucosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables UDP-glucose:glycoprotein glucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables UDP-glucose:glycoprotein glucosyltransferase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in UDP-glucosylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endoplasmic reticulum mannose trimming TAS
    Traceable Author Statement
    more info
     
    involved_in protein N-linked glycosylation via asparagine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum lumen ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum quality control compartment IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    UDP-glucose:glycoprotein glucosyltransferase 2
    Names
    UDP-Glc:glycoprotein glucosyltransferase 2
    UDP-glucose ceramide glucosyltransferase-like 1
    UDP-glucose ceramide glucosyltransferase-like 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020121.4NP_064506.3  UDP-glucose:glycoprotein glucosyltransferase 2 precursor

      See identical proteins and their annotated locations for NP_064506.3

      Status: VALIDATED

      Source sequence(s)
      AF227906, AL162500, BC017759, BC032302
      Consensus CDS
      CCDS9480.1
      UniProtKB/Swiss-Prot
      A6NKL4, Q08AD0, Q5JQR8, Q8N5K0, Q9NYU1, Q9UFC4
      Related
      ENSP00000365938.3, ENST00000376747.8
      Conserved Domains (2) summary
      cd06432
      Location:12311478
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:331189
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      95801580..96053401 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047430471.1XP_047286427.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X6

    2. XM_011521097.2XP_011519399.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X4

      Conserved Domains (2) summary
      cd06432
      Location:12581505
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:331216
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    3. XM_017020662.2XP_016876151.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X5

    4. XM_011521096.2XP_011519398.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X3

      Conserved Domains (2) summary
      cd06432
      Location:12141461
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:331172
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    5. XM_011521095.2XP_011519397.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X2

      Conserved Domains (2) summary
      cd06432
      Location:12311478
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:331189
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    6. XM_011521094.2XP_011519396.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1

      Conserved Domains (2) summary
      cd06432
      Location:12581505
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:331216
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    7. XM_047430473.1XP_047286429.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X8

    8. XM_047430472.1XP_047286428.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X7

    9. XM_047430474.1XP_047286430.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X10

    10. XM_011521099.3XP_011519401.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X9

      Conserved Domains (2) summary
      cd06432
      Location:9041151
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:1862
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    11. XM_047430475.1XP_047286431.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X13

    12. XM_011521102.3XP_011519404.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X12

      Conserved Domains (2) summary
      cd06432
      Location:699946
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:1657
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    13. XM_011521103.3XP_011519405.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X14

      Conserved Domains (2) summary
      cd06432
      Location:586833
      GT8_HUGT1_C_like; The C-terminal domain of HUGT1-like is highly homologous to the GT 8 family
      pfam06427
      Location:1544
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase
    14. XM_011521100.3XP_011519402.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X11

      UniProtKB/TrEMBL
      Q9NV86
      Conserved Domains (1) summary
      pfam06427
      Location:331013
      UDP-g_GGTase; UDP-glucose:Glycoprotein Glucosyltransferase

    RNA

    1. XR_931617.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      95006150..95257608 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374735.1XP_054230710.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X6

    2. XM_054374733.1XP_054230708.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X4

    3. XM_054374734.1XP_054230709.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X5

    4. XM_054374732.1XP_054230707.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X3

    5. XM_054374731.1XP_054230706.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X2

    6. XM_054374730.1XP_054230705.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X1

    7. XM_054374737.1XP_054230712.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X8

    8. XM_054374736.1XP_054230711.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X7

    9. XM_054374739.1XP_054230714.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X10

    10. XM_054374738.1XP_054230713.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X9

    11. XM_054374742.1XP_054230717.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X13

    12. XM_054374741.1XP_054230716.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X12

    13. XM_054374743.1XP_054230718.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X14

    14. XM_054374740.1XP_054230715.1  UDP-glucose:glycoprotein glucosyltransferase 2 isoform X11

      UniProtKB/TrEMBL
      Q9NV86

    RNA

    1. XR_008488774.1 RNA Sequence