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    USP44 ubiquitin specific peptidase 44 [ Homo sapiens (human) ]

    Gene ID: 84101, updated on 10-Dec-2024

    Summary

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    Official Symbol
    USP44provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 44provided by HGNC
    Primary source
    HGNC:HGNC:20064
    See related
    Ensembl:ENSG00000136014 MIM:610993; AllianceGenome:HGNC:20064
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a protease that functions as a deubiquitinating enzyme. The encoded protein is thought to help regulate the spindle assembly checkpoint by preventing early anaphase onset. This protein specifically deubiquitinates CDC20, which stabilizes the anaphase promoting complex/cyclosome. [provided by RefSeq, Dec 2016]
    Expression
    Biased expression in testis (RPKM 9.0), lung (RPKM 1.3) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See USP44 in Genome Data Viewer
    Location:
    12q22
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (95516560..95551681, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (95497607..95532730, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (95910336..95945252, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6810 Neighboring gene ribosomal protein L29 pseudogene 26 Neighboring gene methionyl aminopeptidase 2 Neighboring gene MPRA-validated peak1899 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:95916458-95916958 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:95936387-95936886 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6811 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:96004940-96005508 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr12:96005509-96006077 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:96008766-96009393 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:96016523-96017477 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4739 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:96026735-96027934 Neighboring gene Sharpr-MPRA regulatory region 15569 Neighboring gene phosphoglycerate mutase 1 pseudogene 5 Neighboring gene netrin 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96087614-96088118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:96088119-96088623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6813 Neighboring gene uncharacterized LOC105369919 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:96125327-96125544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6815

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming. Ekstrom TL, et al. Mol Cancer Res, 2024 Sep 4. PMID 38775808, Free PMC Article
    2. Integrated network findings reveal ubiquitin-specific protease 44 overexpression suppresses tumorigenicity of liver cancer. Zhou H, et al. Aging (Albany NY), 2023 May 18. PMID 37204480, Free PMC Article
    3. Epigenetic inactivation of the candidate tumor suppressor USP44 is a frequent and early event in colorectal neoplasia. Sloane MA, et al. Epigenetics, 2014 Aug. PMID 24837038, Free PMC Article
    4. USP44+ Cancer Stem Cell Subclones Contribute to Breast Cancer Aggressiveness by Promoting Vasculogenic Mimicry. Liu T, et al. Mol Cancer Ther, 2015 Sep. PMID 26232424
    5. USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma. Chen Y, et al. Nat Commun, 2022 Jan 25. PMID 35079021, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming.
      Title: USP44 Overexpression Drives a MYC-Like Gene Expression Program in Neuroblastoma through Epigenetic Reprogramming.
    2. RNA-binding protein NOVA1 promotes acute T-lymphocyte leukemia progression by stabilizing USP44 mRNA.
      Title: RNA-binding protein NOVA1 promotes acute T-lymphocyte leukemia progression by stabilizing USP44 mRNA.
    3. MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex.
      Title: MAD2 activates IGF1R/PI3K/AKT pathway and promotes cholangiocarcinoma progression by interfering USP44/LIMA1 complex.
    4. Integrated network findings reveal ubiquitin-specific protease 44 overexpression suppresses tumorigenicity of liver cancer.
      Title: Integrated network findings reveal ubiquitin-specific protease 44 overexpression suppresses tumorigenicity of liver cancer.
    5. USP44 accelerates the growth of T-cell acute lymphoblastic leukemia through interacting with WDR5 and repressing its ubiquitination.
      Title: USP44 accelerates the growth of T-cell acute lymphoblastic leukemia through interacting with WDR5 and repressing its ubiquitination.
    6. USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma.
      Title: USP44 regulates irradiation-induced DNA double-strand break repair and suppresses tumorigenesis in nasopharyngeal carcinoma.
    7. USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer.
      Title: USP44 hypermethylation promotes cell proliferation and metastasis in breast cancer.
    8. CRADD and USP44 mutations in intellectual disability, mild lissencephaly, brain atrophy, developmental delay, strabismus, behavioural problems and skeletal anomalies.
      Title: CRADD and USP44 mutations in intellectual disability, mild lissencephaly, brain atrophy, developmental delay, strabismus, behavioural problems and skeletal anomalies.
    9. The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation.
      Title: The deubiquitinase USP44 promotes Treg function during inflammation by preventing FOXP3 degradation.
    10. USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/beta-catenin pathway via Axin1 deubiquitination.
      Title: USP44 suppresses proliferation and enhances apoptosis in colorectal cancer cells by inactivating the Wnt/β-catenin pathway via Axin1 deubiquitination.
    Submit: New GeneRIF Correction See all GeneRIFs (25)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ14528, DKFZp434D0127

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deubiquitinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antiviral innate immune response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of mitotic metaphase/anaphase transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of ubiquitin protein ligase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein deubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deubiquitination TAS
    Traceable Author Statement
    more info
    		  
    involved_in regulation of cell cycle process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mitotic cell cycle spindle assembly checkpoint ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulatory T cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IC
    Inferred by Curator
    more info
    		 PubMed 
    is_active_in mitotic spindle IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 44
    Names
    deubiquitinating enzyme 44
    ubiquitin specific protease 44
    ubiquitin thioesterase 44
    ubiquitin thiolesterase 44
    ubiquitin-specific-processing protease 44
    NP_001035862.1
    NP_001265322.1
    NP_001334865.1
    NP_001334866.1
    NP_115523.2
    XP_005269229.1
    XP_005269230.1
    XP_005269231.1
    XP_011537102.1
    XP_011537103.1
    XP_011537104.1
    XP_011537105.1
    XP_011537106.1
    XP_011537107.1
    XP_011537108.1
    XP_047285598.1
    XP_047285599.1
    XP_047285600.1
    XP_047285601.1
    XP_047285602.1
    XP_047285603.1
    XP_054229381.1
    XP_054229382.1
    XP_054229383.1
    XP_054229384.1
    XP_054229385.1
    XP_054229386.1
    XP_054229387.1
    XP_054229388.1
    XP_054229389.1
    XP_054229390.1
    XP_054229391.1
    XP_054229392.1
    XP_054229393.1
    XP_054229394.1
    XP_054229395.1
    XP_054229396.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_052622.1 RefSeqGene

      Range
      5054..39970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042403.3 → NP_001035862.1  ubiquitin carboxyl-terminal hydrolase 44

      See identical proteins and their annotated locations for NP_001035862.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the same protein as variants 1, 3, 4, and 6.
      Source sequence(s)
      AC018475, AK027434, AK315697, BM023146, DA092275, DB462518
      Consensus CDS
      CCDS9053.1
      UniProtKB/Swiss-Prot
      B2RDW3, Q9H0E7
      Related
      ENSP00000376806.2, ENST00000393091.6
      Conserved Domains (3) summary
      cl02553
      Location:274 → 676
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:272 → 675
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    2. NM_001278393.2 → NP_001265322.1  ubiquitin carboxyl-terminal hydrolase 44

      See identical proteins and their annotated locations for NP_001265322.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the same protein as variants 1, 2, 5, and 6.
      Source sequence(s)
      AC018475, AK027434, AK315697, BM023146, DA092275, DB454726
      Consensus CDS
      CCDS9053.1
      UniProtKB/Swiss-Prot
      B2RDW3, Q9H0E7
      Related
      ENSP00000442629.2, ENST00000537435.2
      Conserved Domains (3) summary
      cl02553
      Location:274 → 676
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:272 → 675
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    3. NM_001347936.2 → NP_001334865.1  ubiquitin carboxyl-terminal hydrolase 44

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes the same protein as variants 1, 2, 3, and 6.
      Source sequence(s)
      AC018475
      Consensus CDS
      CCDS9053.1
      UniProtKB/Swiss-Prot
      B2RDW3, Q9H0E7

    4. NM_001347937.2 → NP_001334866.1  ubiquitin carboxyl-terminal hydrolase 44

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) encodes the same protein as variants 1, 2, 3, and 5.
      Source sequence(s)
      AC018475
      Consensus CDS
      CCDS9053.1
      UniProtKB/Swiss-Prot
      B2RDW3, Q9H0E7

    5. NM_032147.5 → NP_115523.2  ubiquitin carboxyl-terminal hydrolase 44

      See identical proteins and their annotated locations for NP_115523.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the same protein as variants 2, 3, 5, and 6.
      Source sequence(s)
      AC018475, AK315697, BM023146, DA092275, DB443014, DB456039
      Consensus CDS
      CCDS9053.1
      UniProtKB/Swiss-Prot
      B2RDW3, Q9H0E7
      Related
      ENSP00000258499.3, ENST00000258499.8
      Conserved Domains (3) summary
      cl02553
      Location:274 → 676
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:272 → 675
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RNA

    1. NR_125360.3 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) is represented as non-coding because the use of the 5'-most supported translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC018475

    2. NR_144944.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018475

    3. NR_144945.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018475

    4. NR_144946.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018475

    5. NR_144947.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018475

    6. NR_144948.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC018475

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      95516560..95551681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429645.1 → XP_047285601.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

      UniProtKB/Swiss-Prot
      B2RDW3, Q9H0E7

    2. XM_011538803.1 → XP_011537105.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011537105.1

      Conserved Domains (3) summary
      cl02553
      Location:274 → 707
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:272 → 706
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    3. XM_005269172.2 → XP_005269229.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_005269229.1

      Conserved Domains (3) summary
      cl02553
      Location:274 → 707
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:272 → 706
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    4. XM_047429643.1 → XP_047285599.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

      UniProtKB/Swiss-Prot
      B2RDW3, Q9H0E7

    5. XM_011538800.3 → XP_011537102.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011537102.1

      Conserved Domains (3) summary
      cl02553
      Location:274 → 707
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:272 → 706
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    6. XM_047429644.1 → XP_047285600.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

      UniProtKB/Swiss-Prot
      B2RDW3, Q9H0E7

    7. XM_011538805.3 → XP_011537107.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011537107.1

      Conserved Domains (3) summary
      cl02553
      Location:274 → 707
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:272 → 706
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    8. XM_005269174.2 → XP_005269231.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_005269231.1

      Conserved Domains (3) summary
      cl02553
      Location:274 → 707
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:272 → 706
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    9. XM_047429642.1 → XP_047285598.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

      UniProtKB/Swiss-Prot
      B2RDW3, Q9H0E7

    10. XM_011538802.2 → XP_011537104.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011537104.1

      Conserved Domains (3) summary
      cl02553
      Location:274 → 707
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:272 → 706
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    11. XM_011538801.2 → XP_011537103.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011537103.1

      Conserved Domains (3) summary
      cl02553
      Location:274 → 707
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:272 → 706
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    12. XM_011538804.3 → XP_011537106.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_011537106.1

      Conserved Domains (3) summary
      cl02553
      Location:274 → 707
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:272 → 706
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    13. XM_005269173.2 → XP_005269230.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

      See identical proteins and their annotated locations for XP_005269230.1

      Conserved Domains (3) summary
      cl02553
      Location:274 → 707
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:272 → 706
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    14. XM_047429646.1 → XP_047285602.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X4

      UniProtKB/TrEMBL
      F8VRI7
      Related
      ENSP00000448670.1, ENST00000552440.5

    15. XM_047429647.1 → XP_047285603.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X4

      UniProtKB/TrEMBL
      F8VRI7

    16. XM_011538806.3 → XP_011537108.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X3

      Conserved Domains (3) summary
      cd02257
      Location:421 → 496
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      cl02553
      Location:274 → 438
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam02148
      Location:29 → 90
      zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

    RNA

    1. XR_944757.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      95497607..95532730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373417.1 → XP_054229392.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

    2. XM_054373413.1 → XP_054229388.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    3. XM_054373406.1 → XP_054229381.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    4. XM_054373418.1 → XP_054229393.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

    5. XM_054373410.1 → XP_054229385.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    6. XM_054373416.1 → XP_054229391.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

    7. XM_054373414.1 → XP_054229389.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    8. XM_054373408.1 → XP_054229383.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    9. XM_054373415.1 → XP_054229390.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X2

    10. XM_054373409.1 → XP_054229384.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    11. XM_054373411.1 → XP_054229386.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    12. XM_054373407.1 → XP_054229382.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    13. XM_054373412.1 → XP_054229387.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X1

    14. XM_054373420.1 → XP_054229395.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X4

    15. XM_054373421.1 → XP_054229396.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X4

    16. XM_054373419.1 → XP_054229394.1  ubiquitin carboxyl-terminal hydrolase 44 isoform X3

    RNA

    1. XR_008488692.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H0E7.2 GenPept UniProtKB/Swiss-Prot:Q9H0E7

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