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    KIF21A kinesin family member 21A [ Homo sapiens (human) ]

    Gene ID: 55605, updated on 10-Dec-2024

    Summary

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    Official Symbol
    KIF21Aprovided by HGNC
    Official Full Name
    kinesin family member 21Aprovided by HGNC
    Primary source
    HGNC:HGNC:19349
    See related
    Ensembl:ENSG00000139116 MIM:608283; AllianceGenome:HGNC:19349
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FEOM1; CFEOM1; FEOM3A
    Summary
    This gene encodes a member of the KIF4 subfamily of kinesin-like motor proteins. The encoded protein is characterized by an N-terminal motor domain a coiled-coil stalk domain and a C-terminal WD-40 repeat domain. This protein may be involved in microtubule dependent transport. Mutations in this gene are the cause of congenital fibrosis of extraocular muscles-1. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Mar 2010]
    Expression
    Broad expression in brain (RPKM 25.3), kidney (RPKM 9.6) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See KIF21A in Genome Data Viewer
    Location:
    12q12
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (39293228..39443120, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (39243102..39393006, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (39687030..39836922, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984484 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:39456016-39456953 Neighboring gene long intergenic non-protein coding RNA 2406 Neighboring gene NANOG hESC enhancer GRCh37_chr12:39523406-39523907 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:39584065-39584264 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr12:39671001-39672200 Neighboring gene uncharacterized LOC101927019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6197 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6198 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:39787553-39788229 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6199 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:39805818-39806556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:39836751-39837251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6201 Neighboring gene uncharacterized LOC124902919 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:39845559-39846258 Neighboring gene ribosomal protein L7a pseudogene 74

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Congential fibrosis of the extraocular muscles type I (CFEOM1) on the Arabian Peninsula. Khan AO, et al. Ophthalmic Genet, 2008 Mar. PMID 18363169
    2. Prognostic value of Kinesin-4 family genes mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy. Han Q, et al. Cancer Med, 2019 Nov. PMID 31489986, Free PMC Article
    3. Clinical characteristics of a KIF21A mutation in a Chinese family with congenital fibrosis of the extraocular muscles type 1. Chen H, et al. Medicine (Baltimore), 2017 Sep. PMID 28930843, Free PMC Article
    4. KIF21A mutation in two Chinese families with congenital fibrosis of the extraocular muscles type 1 and 3. Chen J, et al. Mol Med Rep, 2016 Oct. PMID 27513105, Free PMC Article
    5. A rare case of congenital fibrosis of extraocular muscle type 1A due to KIF21A mutation with Marcus Gunn jaw-winking phenomenon. Kaçar Bayram A, et al. Eur J Paediatr Neurol, 2015 Nov. PMID 26190014

    See all (93) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.
      Title: Nephrotic-syndrome-associated mutation of KANK2 induces pathologic binding competition with physiological interactor KIF21A.
    2. Phenotypic heterogeneity associated with KIF21A: Two new cases and review of the literature.
      Title: Phenotypic heterogeneity associated with KIF21A: Two new cases and review of the literature.
    3. Bi-allelic loss-of-function variants in KIF21A cause severe fetal akinesia with arthrogryposis multiplex.
      Title: Bi-allelic loss-of-function variants in KIF21A cause severe fetal akinesia with arthrogryposis multiplex.
    4. [Identification of a novel KIF21A gene mutation in a Chinese family with congenital fibrosis of the extraocular muscles].
      Title: [Identification of a novel KIF21A gene mutation in a Chinese family with congenital fibrosis of the extraocular muscles].
    5. KIF21A regulates breast cancer aggressiveness and is prognostic of patient survival and tumor recurrence.
      Title: KIF21A regulates breast cancer aggressiveness and is prognostic of patient survival and tumor recurrence.
    6. KIF21A pathogenic variants cause congenital fibrosis of extraocular muscles type 3.
      Title: KIF21A pathogenic variants cause congenital fibrosis of extraocular muscles type 3.
    7. Outcomes of strabismus surgery in genetically confirmed congenital fibrosis of the extraocular muscles.
      Title: Outcomes of strabismus surgery in genetically confirmed congenital fibrosis of the extraocular muscles.
    8. Prognostic value of Kinesin-4 family genes mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy.
      Title: Prognostic value of Kinesin-4 family genes mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy.
    9. Several key residues (i.e. Thr-1147, Leu-1152, Leu-1153, and Tyr-1154) at the C-terminal half of the KIF21A KBD peptide contact with the hydrophobic patch formed by Tyr-1176, Met-1209, Leu-1210, Leu-1213, and Leu-1248 from KANK1.
      Title: Structural analyses of key features in the KANK1·KIF21A complex yield mechanistic insights into the cross-talk between microtubules and the cell cortex.
    10. We describe a recurrent (c.2860C>T) missense KIF21A mutation identified in a Chinese family with CFEOM1 (congenital fibrosis of the extraocular muscles type 1) phenotypes.
      Title: Clinical characteristics of a KIF21A mutation in a Chinese family with congenital fibrosis of the extraocular muscles type 1.
    Submit: New GeneRIF Correction See all GeneRIFs (45)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20052, KIAA1708, DKFZp779C159

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ankyrin repeat binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables plus-end-directed microtubule motor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cortical microtubule organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in axonal growth cone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin-like protein KIF21A
    Names
    kinesin-like protein KIF2
    renal carcinoma antigen NY-REN-62

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017067.1 RefSeqGene

      Range
      5271..155163
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001173463.2 → NP_001166934.1  kinesin-like protein KIF21A isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks four in-frame exons in the coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      AB051495, AB290166, AC084373, AW131223, BC136414
      Consensus CDS
      CCDS53775.1
      UniProtKB/TrEMBL
      A0A1B0GV47
      Related
      ENSP00000445606.2, ENST00000544797.6
      Conserved Domains (7) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1308 → 1618
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:655 → 791
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:1302 → 1615
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:649 → 786
      FliJ; Flagellar FliJ protein
      sd00039
      Location:1353 → 1412
      7WD40; WD40 repeat [structural motif]

    2. NM_001173464.2 → NP_001166935.1  kinesin-like protein KIF21A isoform 1

      See identical proteins and their annotated locations for NP_001166935.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AB051495, AB290166, AW131223, AY368076
      Consensus CDS
      CCDS53776.1
      UniProtKB/Swiss-Prot
      A8MX28, B0I1R9, B9EGE4, F5H0C3, F5H219, Q2UVF1, Q6UKL9, Q7Z4S6, Q7Z668, Q86WZ5, Q8IVZ8, Q9C0F5, Q9NXU4, Q9Y590
      UniProtKB/TrEMBL
      A0A1B0GV47
      Related
      ENSP00000354878.5, ENST00000361418.10
      Conserved Domains (7) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1345 → 1655
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668 → 804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:1339 → 1652
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662 → 799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:1390 → 1449
      7WD40; WD40 repeat [structural motif]

    3. NM_001173465.2 → NP_001166936.1  kinesin-like protein KIF21A isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks four in-frame exons in the coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AB051495, AB290166, AC084373, AC090668, AM177179, AW131223, BC041430, DA293947
      Consensus CDS
      CCDS53774.1
      UniProtKB/TrEMBL
      A0A1B0GV47
      Related
      ENSP00000438075.2, ENST00000541463.6
      Conserved Domains (7) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1292 → 1602
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:655 → 791
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:1286 → 1599
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:649 → 786
      FliJ; Flagellar FliJ protein
      sd00039
      Location:1337 → 1396
      7WD40; WD40 repeat [structural motif]

    4. NM_001378439.1 → NP_001365368.1  kinesin-like protein KIF21A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC084373, AC090668, AC121334
      UniProtKB/TrEMBL
      A0A1B0GV47
      Conserved Domains (6) summary
      COG1196
      Location:644 → 1004
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00200
      Location:1340 → 1653
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1391 → 1450
      7WD40; WD40 repeat [structural motif]
      pfam10174
      Location:364 → 836
      Cast; RIM-binding protein of the cytomatrix active zone
      cd22263
      Location:936 → 1017
      Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

    5. NM_001378440.1 → NP_001365369.1  kinesin-like protein KIF21A isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC084373, AC090668, AC121334
      UniProtKB/TrEMBL
      A0A1B0GV47
      Conserved Domains (6) summary
      COG1196
      Location:644 → 1004
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00200
      Location:1335 → 1648
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1386 → 1445
      7WD40; WD40 repeat [structural motif]
      pfam10174
      Location:364 → 836
      Cast; RIM-binding protein of the cytomatrix active zone
      cd22263
      Location:936 → 1017
      Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

    6. NM_001378441.1 → NP_001365370.1  kinesin-like protein KIF21A isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC084373, AC090668, AC121334
      UniProtKB/TrEMBL
      A0A1B0GV47
      Related
      ENSP00000490369.1, ENST00000636569.1
      Conserved Domains (6) summary
      COG1196
      Location:631 → 991
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd00200
      Location:1327 → 1640
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      sd00039
      Location:1378 → 1437
      7WD40; WD40 repeat [structural motif]
      pfam10174
      Location:364 → 823
      Cast; RIM-binding protein of the cytomatrix active zone
      cd22263
      Location:923 → 1004
      Rcc_KIF21A; regulatory coiled-coil domain found in kinesin-like protein KIF21A

    7. NM_017641.4 → NP_060111.2  kinesin-like protein KIF21A isoform 2

      See identical proteins and their annotated locations for NP_060111.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AB290166, AC084373, AW131223
      Consensus CDS
      CCDS31773.1
      UniProtKB/TrEMBL
      A0A1B0GV47
      Related
      ENSP00000354851.3, ENST00000361961.7
      Conserved Domains (7) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1332 → 1642
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:655 → 791
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:1326 → 1639
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:649 → 786
      FliJ; Flagellar FliJ protein
      sd00039
      Location:1377 → 1436
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      39293228..39443120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429133.1 → XP_047285089.1  kinesin-like protein KIF21A isoform X26

      UniProtKB/TrEMBL
      A0A1B0GV47

    2. XM_047429128.1 → XP_047285084.1  kinesin-like protein KIF21A isoform X18

      UniProtKB/TrEMBL
      A0A1B0GV47

    3. XM_047429123.1 → XP_047285079.1  kinesin-like protein KIF21A isoform X11

      UniProtKB/TrEMBL
      A0A1B0GV47

    4. XM_047429129.1 → XP_047285085.1  kinesin-like protein KIF21A isoform X23

      UniProtKB/TrEMBL
      A0A1B0GV47

    5. XM_017019609.3 → XP_016875098.1  kinesin-like protein KIF21A isoform X20

      UniProtKB/TrEMBL
      A0A1B0GV47

    6. XM_047429120.1 → XP_047285076.1  kinesin-like protein KIF21A isoform X7

      UniProtKB/TrEMBL
      A0A1B0GV47

    7. XM_006719493.4 → XP_006719556.1  kinesin-like protein KIF21A isoform X5

      UniProtKB/TrEMBL
      A0A1B0GV47
      Conserved Domains (7) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1326 → 1636
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:655 → 791
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:1320 → 1633
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:649 → 786
      FliJ; Flagellar FliJ protein
      sd00039
      Location:1371 → 1430
      7WD40; WD40 repeat [structural motif]

    8. XM_017019611.3 → XP_016875100.1  kinesin-like protein KIF21A isoform X22

      UniProtKB/TrEMBL
      A0A1B0GV47

    9. XM_047429127.1 → XP_047285083.1  kinesin-like protein KIF21A isoform X17

      UniProtKB/TrEMBL
      A0A1B0GV47

    10. XM_017019608.3 → XP_016875097.1  kinesin-like protein KIF21A isoform X9

      UniProtKB/TrEMBL
      A0A1B0GV47

    11. XM_017019607.3 → XP_016875096.1  kinesin-like protein KIF21A isoform X3

      UniProtKB/TrEMBL
      A0A1B0GV47

    12. XM_047429132.1 → XP_047285088.1  kinesin-like protein KIF21A isoform X25

      UniProtKB/TrEMBL
      A0A1B0GV47

    13. XM_047429125.1 → XP_047285081.1  kinesin-like protein KIF21A isoform X15

      UniProtKB/TrEMBL
      A0A1B0GV47

    14. XM_047429130.1 → XP_047285086.1  kinesin-like protein KIF21A isoform X24

      UniProtKB/TrEMBL
      A0A1B0GV47

    15. XM_047429122.1 → XP_047285078.1  kinesin-like protein KIF21A isoform X10

      UniProtKB/TrEMBL
      A0A1B0GV47

    16. XM_011538556.4 → XP_011536858.1  kinesin-like protein KIF21A isoform X6

      UniProtKB/TrEMBL
      A0A1B0GV47
      Conserved Domains (7) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1323 → 1633
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668 → 804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:1317 → 1630
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662 → 799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:1368 → 1427
      7WD40; WD40 repeat [structural motif]

    17. XM_017019610.3 → XP_016875099.1  kinesin-like protein KIF21A isoform X21

      UniProtKB/TrEMBL
      A0A1B0GV47

    18. XM_047429126.1 → XP_047285082.1  kinesin-like protein KIF21A isoform X16

      UniProtKB/TrEMBL
      A0A1B0GV47

    19. XM_047429121.1 → XP_047285077.1  kinesin-like protein KIF21A isoform X8

      UniProtKB/TrEMBL
      A0A1B0GV47

    20. XM_047429119.1 → XP_047285075.1  kinesin-like protein KIF21A isoform X2

      UniProtKB/TrEMBL
      A0A1B0GV47

    21. XM_005269009.4 → XP_005269066.1  kinesin-like protein KIF21A isoform X1

      UniProtKB/TrEMBL
      A0A1B0GV47
      Conserved Domains (7) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1339 → 1649
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668 → 804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:1333 → 1646
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662 → 799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:1384 → 1443
      7WD40; WD40 repeat [structural motif]

    22. XM_005269014.4 → XP_005269071.1  kinesin-like protein KIF21A isoform X19

      UniProtKB/TrEMBL
      A0A1B0GV47
      Conserved Domains (7) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1285 → 1595
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668 → 804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:1279 → 1592
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662 → 799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:1330 → 1389
      7WD40; WD40 repeat [structural motif]

    23. XM_005269013.4 → XP_005269070.1  kinesin-like protein KIF21A isoform X14

      UniProtKB/TrEMBL
      A0A1B0GV47
      Conserved Domains (7) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1298 → 1608
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668 → 804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:1292 → 1605
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662 → 799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:1343 → 1402
      7WD40; WD40 repeat [structural motif]

    24. XM_006719494.4 → XP_006719557.1  kinesin-like protein KIF21A isoform X13

      UniProtKB/TrEMBL
      A0A1B0GV47
      Conserved Domains (7) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1302 → 1612
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668 → 804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:1296 → 1609
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662 → 799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:1347 → 1406
      7WD40; WD40 repeat [structural motif]

    25. XM_005269012.4 → XP_005269069.1  kinesin-like protein KIF21A isoform X12

      UniProtKB/TrEMBL
      A0A1B0GV47
      Conserved Domains (7) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1303 → 1613
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668 → 804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:1297 → 1610
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662 → 799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:1348 → 1407
      7WD40; WD40 repeat [structural motif]

    26. XM_005269011.4 → XP_005269068.1  kinesin-like protein KIF21A isoform X4

      UniProtKB/TrEMBL
      A0A1B0GV47
      Conserved Domains (7) summary
      smart00129
      Location:9 → 378
      KISc; Kinesin motor, catalytic domain. ATPase
      COG2319
      Location:1328 → 1638
      WD40; WD40 repeat [General function prediction only]
      COG2882
      Location:668 → 804
      FliJ; Flagellar biosynthesis chaperone FliJ [Cell motility]
      cd00200
      Location:1322 → 1635
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cd01372
      Location:8 → 372
      KISc_KIF4; Kinesin motor domain, KIF4-like subfamily
      pfam02050
      Location:662 → 799
      FliJ; Flagellar FliJ protein
      sd00039
      Location:1373 → 1432
      7WD40; WD40 repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      39243102..39393006 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372520.1 → XP_054228495.1  kinesin-like protein KIF21A isoform X26

      UniProtKB/TrEMBL
      A0A1B0GV47

    2. XM_054372512.1 → XP_054228487.1  kinesin-like protein KIF21A isoform X18

      UniProtKB/TrEMBL
      A0A1B0GV47

    3. XM_054372505.1 → XP_054228480.1  kinesin-like protein KIF21A isoform X11

      UniProtKB/TrEMBL
      A0A1B0GV47

    4. XM_054372517.1 → XP_054228492.1  kinesin-like protein KIF21A isoform X23

      UniProtKB/TrEMBL
      A0A1B0GV47

    5. XM_054372514.1 → XP_054228489.1  kinesin-like protein KIF21A isoform X20

      UniProtKB/TrEMBL
      A0A1B0GV47

    6. XM_054372501.1 → XP_054228476.1  kinesin-like protein KIF21A isoform X7

      UniProtKB/TrEMBL
      A0A1B0GV47

    7. XM_054372499.1 → XP_054228474.1  kinesin-like protein KIF21A isoform X5

      UniProtKB/TrEMBL
      A0A1B0GV47

    8. XM_054372516.1 → XP_054228491.1  kinesin-like protein KIF21A isoform X22

      UniProtKB/TrEMBL
      A0A1B0GV47

    9. XM_054372511.1 → XP_054228486.1  kinesin-like protein KIF21A isoform X17

      UniProtKB/TrEMBL
      A0A1B0GV47

    10. XM_054372503.1 → XP_054228478.1  kinesin-like protein KIF21A isoform X9

      UniProtKB/TrEMBL
      A0A1B0GV47

    11. XM_054372497.1 → XP_054228472.1  kinesin-like protein KIF21A isoform X3

      UniProtKB/TrEMBL
      A0A1B0GV47

    12. XM_054372519.1 → XP_054228494.1  kinesin-like protein KIF21A isoform X25

      UniProtKB/TrEMBL
      A0A1B0GV47

    13. XM_054372509.1 → XP_054228484.1  kinesin-like protein KIF21A isoform X15

      UniProtKB/TrEMBL
      A0A1B0GV47

    14. XM_054372518.1 → XP_054228493.1  kinesin-like protein KIF21A isoform X24

      UniProtKB/TrEMBL
      A0A1B0GV47

    15. XM_054372504.1 → XP_054228479.1  kinesin-like protein KIF21A isoform X10

      UniProtKB/TrEMBL
      A0A1B0GV47

    16. XM_054372500.1 → XP_054228475.1  kinesin-like protein KIF21A isoform X6

      UniProtKB/TrEMBL
      A0A1B0GV47

    17. XM_054372515.1 → XP_054228490.1  kinesin-like protein KIF21A isoform X21

      UniProtKB/TrEMBL
      A0A1B0GV47

    18. XM_054372510.1 → XP_054228485.1  kinesin-like protein KIF21A isoform X16

      UniProtKB/TrEMBL
      A0A1B0GV47

    19. XM_054372502.1 → XP_054228477.1  kinesin-like protein KIF21A isoform X8

      UniProtKB/TrEMBL
      A0A1B0GV47

    20. XM_054372496.1 → XP_054228471.1  kinesin-like protein KIF21A isoform X2

      UniProtKB/TrEMBL
      A0A1B0GV47

    21. XM_054372495.1 → XP_054228470.1  kinesin-like protein KIF21A isoform X1

      UniProtKB/TrEMBL
      A0A1B0GV47

    22. XM_054372513.1 → XP_054228488.1  kinesin-like protein KIF21A isoform X19

      UniProtKB/TrEMBL
      A0A1B0GV47

    23. XM_054372508.1 → XP_054228483.1  kinesin-like protein KIF21A isoform X14

      UniProtKB/TrEMBL
      A0A1B0GV47

    24. XM_054372507.1 → XP_054228482.1  kinesin-like protein KIF21A isoform X13

      UniProtKB/TrEMBL
      A0A1B0GV47

    25. XM_054372506.1 → XP_054228481.1  kinesin-like protein KIF21A isoform X12

      UniProtKB/TrEMBL
      A0A1B0GV47

    26. XM_054372498.1 → XP_054228473.1  kinesin-like protein KIF21A isoform X4

      UniProtKB/TrEMBL
      A0A1B0GV47

    RNA

    1. XR_008488639.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7Z4S6.2 GenPept UniProtKB/Swiss-Prot:Q7Z4S6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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