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    ZBTB37 zinc finger and BTB domain containing 37 [ Homo sapiens (human) ]

    Gene ID: 84614, updated on 27-Nov-2024

    Summary

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    Official Symbol
    ZBTB37provided by HGNC
    Official Full Name
    zinc finger and BTB domain containing 37provided by HGNC
    Primary source
    HGNC:HGNC:28365
    See related
    Ensembl:ENSG00000185278 AllianceGenome:HGNC:28365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF908; D430004I08Rik
    Summary
    Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; regulation of cytokine production; and regulation of immune system process. Predicted to be located in chromatin. Predicted to be active in nucleoplasm. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 2.8), bone marrow (RPKM 1.4) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZBTB37 in Genome Data Viewer
    Location:
    1q25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (173868082..173903547)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (173226202..173261663)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (173837220..173872685)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173837597-173838796 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2118 Neighboring gene growth arrest specific 5 Neighboring gene small nucleolar RNA, C/D box 75 Neighboring gene small nucleolar RNA, C/D box 74 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:173863193-173864392 Neighboring gene serpin family C member 1 Neighboring gene uncharacterized LOC124904457 Neighboring gene RNA, 5S ribosomal pseudogene 67

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of multi-SH3 domain-containing protein interactome in pancreatic cancer: a yeast two-hybrid approach. Thalappilly S, et al. Proteomics, 2008 Aug. PMID 18654987
    2. N(6)-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cheng Y, et al. Cancer Cell, 2021 Jul 12. PMID 34048709, Free PMC Article
    3. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. Katsogiannou M, et al. Mol Cell Proteomics, 2014 Dec. PMID 25277244, Free PMC Article
    4. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. Trynka G, et al. Gut, 2009 Aug. PMID 19240061
    5. Impact of cytosine methylation on DNA binding specificities of human transcription factors. Yin Y, et al. Science, 2017 May 5. PMID 28473536, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association. (HuGE Navigator)
      Title: Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC2629

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokine production IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of immune system process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger and BTB domain-containing protein 37

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122770.3 → NP_001116242.1  zinc finger and BTB domain-containing protein 37 isoform a

      See identical proteins and their annotated locations for NP_001116242.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AL136170, KF455104
      Consensus CDS
      CCDS44278.1
      UniProtKB/Swiss-Prot
      Q5TC79, Q5TC80, Q96M87, Q9BQ88
      UniProtKB/TrEMBL
      B7Z7Z4
      Related
      ENSP00000356674.4, ENST00000367701.10
      Conserved Domains (4) summary
      sd00017
      Location:375 → 395
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:7 → 129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:401 → 423
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:416 → 438
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001346115.2 → NP_001333044.1  zinc finger and BTB domain-containing protein 37 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c) is shorter at the C-terminus compared to isoform a.
      Source sequence(s)
      AL136170, KF455104
      Consensus CDS
      CCDS86033.1
      UniProtKB/Swiss-Prot
      Q5TC79
      UniProtKB/TrEMBL
      B7Z7Z4
      Conserved Domains (1) summary
      cd18222
      Location:7 → 129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    3. NM_001369846.1 → NP_001356775.1  zinc finger and BTB domain-containing protein 37 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL136170, KF455104
      Consensus CDS
      CCDS86033.1
      Related
      ENSP00000356677.1, ENST00000367704.5
      Conserved Domains (1) summary
      cd18222
      Location:7 → 129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    4. NM_001395199.1 → NP_001382128.1  zinc finger and BTB domain-containing protein 37 isoform a

      Status: VALIDATED

      Source sequence(s)
      AL136170, KF455104
      Consensus CDS
      CCDS44278.1
      UniProtKB/Swiss-Prot
      Q5TC79, Q5TC80, Q96M87, Q9BQ88
      UniProtKB/TrEMBL
      B7Z7Z4
      Related
      ENSP00000511931.1, ENST00000695459.1
      Conserved Domains (4) summary
      sd00017
      Location:375 → 395
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:7 → 129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:401 → 423
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:416 → 438
      zf-H2C2_2; Zinc-finger double domain

    5. NM_001395200.1 → NP_001382129.1  zinc finger and BTB domain-containing protein 37 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL136170
      Conserved Domains (1) summary
      cd18222
      Location:7 → 129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    6. NM_001395201.1 → NP_001382130.1  zinc finger and BTB domain-containing protein 37 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL136170
      Conserved Domains (1) summary
      cd18222
      Location:7 → 129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    7. NM_001395202.1 → NP_001382131.1  zinc finger and BTB domain-containing protein 37 isoform d

      Status: VALIDATED

      Source sequence(s)
      AL136170
      Conserved Domains (1) summary
      cd18222
      Location:7 → 129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    8. NM_032522.5 → NP_115911.1  zinc finger and BTB domain-containing protein 37 isoform b

      See identical proteins and their annotated locations for NP_115911.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AL136170, KF455104
      Consensus CDS
      CCDS1312.1
      UniProtKB/Swiss-Prot
      Q5TC79
      Related
      ENSP00000356675.1, ENST00000367702.1
      Conserved Domains (1) summary
      pfam00651
      Location:22 → 122
      BTB; BTB/POZ domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      173868082..173903547
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017002557.2 → XP_016858046.1  zinc finger and BTB domain-containing protein 37 isoform X2

      UniProtKB/Swiss-Prot
      Q5TC79
      Conserved Domains (1) summary
      cd18222
      Location:7 → 129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    2. XM_011510062.4 → XP_011508364.1  zinc finger and BTB domain-containing protein 37 isoform X2

      See identical proteins and their annotated locations for XP_011508364.1

      UniProtKB/Swiss-Prot
      Q5TC79
      Conserved Domains (1) summary
      cd18222
      Location:7 → 129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    3. XM_006711578.5 → XP_006711641.1  zinc finger and BTB domain-containing protein 37 isoform X1

      See identical proteins and their annotated locations for XP_006711641.1

      UniProtKB/Swiss-Prot
      Q5TC79, Q5TC80, Q96M87, Q9BQ88
      UniProtKB/TrEMBL
      B7Z7Z4
      Conserved Domains (4) summary
      sd00017
      Location:375 → 395
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd18222
      Location:7 → 129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)
      pfam00096
      Location:401 → 423
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:416 → 438
      zf-H2C2_2; Zinc-finger double domain

    4. XM_047432197.1 → XP_047288153.1  zinc finger and BTB domain-containing protein 37 isoform X2

    5. XM_017002558.2 → XP_016858047.1  zinc finger and BTB domain-containing protein 37 isoform X3

      UniProtKB/Swiss-Prot
      Q5TC79
      Conserved Domains (1) summary
      cd18222
      Location:7 → 129
      BTB_POZ_ZBTB37; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      173226202..173261663
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339219.1 → XP_054195194.1  zinc finger and BTB domain-containing protein 37 isoform X2

    2. XM_054339218.1 → XP_054195193.1  zinc finger and BTB domain-containing protein 37 isoform X2

    3. XM_054339217.1 → XP_054195192.1  zinc finger and BTB domain-containing protein 37 isoform X1

      UniProtKB/Swiss-Prot
      Q5TC79, Q5TC80, Q96M87, Q9BQ88

    4. XM_054339221.1 → XP_054195196.1  zinc finger and BTB domain-containing protein 37 isoform X2

    5. XM_054339220.1 → XP_054195195.1  zinc finger and BTB domain-containing protein 37 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5TC79.1 GenPept UniProtKB/Swiss-Prot:Q5TC79

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