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    DNAH14 dynein axonemal heavy chain 14 [ Homo sapiens (human) ]

    Gene ID: 127602, updated on 27-Nov-2024

    Summary

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    Official Symbol
    DNAH14provided by HGNC
    Official Full Name
    dynein axonemal heavy chain 14provided by HGNC
    Primary source
    HGNC:HGNC:2945
    See related
    Ensembl:ENSG00000185842 MIM:603341; AllianceGenome:HGNC:2945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HL18; HL-18; C1orf67; Dnahc14
    Summary
    Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. Two major classes of dyneins, axonemal and cytoplasmic, have been identified. DNAH14 is an axonemal dynein heavy chain (DHC) (Vaughan et al., 1996 [PubMed 8812413]).[supplied by OMIM, Mar 2008]
    Expression
    Biased expression in testis (RPKM 2.0), thyroid (RPKM 0.3) and 6 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See DNAH14 in Genome Data Viewer
    Location:
    1q42.12
    Exon count:
    90
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (224929654..225399286)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (224118326..224587576)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (225117356..225586988)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373108 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:224988386-224988929 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:225027656-225028156 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:225046922-225048121 Neighboring gene uncharacterized LOC105373109 Neighboring gene uncharacterized LOC124904524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1854 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:225333859-225334360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:225334361-225334860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1855 Neighboring gene MPRA-validated peak726 silencer Neighboring gene MPRA-validated peak727 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2619 Neighboring gene uncharacterized LOC124904525 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_5491 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:225614150-225614822 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:225614823-225615494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2621 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2622 Neighboring gene CRISPRi-validated cis-regulatory element chr1.11936 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:225633853-225634413 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:225634414-225634974 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:225634975-225635534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:225643575-225644075 Neighboring gene Sharpr-MPRA regulatory region 13241 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:225648195-225648876 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:225653249-225654138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2624 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2625 Neighboring gene long intergenic non-protein coding RNA 2765 Neighboring gene lamin B receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Circular RNA DNAH14 molecular mechanism in an experimental model of hepatocellular carcinoma treated with Cobalt chloride to mimic the hypoxia-like response of transcatheter arterial chemoembolization. Liao Q, et al. Sci Rep, 2024 Jan 23. PMID 38263208, Free PMC Article
    2. DNAH14 variants are associated with neurodevelopmental disorders. Li J, et al. Hum Mutat, 2022 Jul. PMID 35438214
    3. Clinical and Genetic Spectrum of Children With Primary Ciliary Dyskinesia in China. Guan Y, et al. Chest, 2021 May. PMID 33577779, Free PMC Article
    4. Identification of novel mutations in endometrial cancer patients by whole-exome sequencing. Chang YS, et al. Int J Oncol, 2017 May. PMID 28339086
    5. Identification of embryonic lethal genes in humans by autozygosity mapping and exome sequencing in consanguineous families. Shamseldin HE, et al. Genome Biol, 2015 Jun 3. PMID 26036949, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Circular RNA DNAH14 molecular mechanism in an experimental model of hepatocellular carcinoma treated with Cobalt chloride to mimic the hypoxia-like response of transcatheter arterial chemoembolization.
      Title: Circular RNA DNAH14 molecular mechanism in an experimental model of hepatocellular carcinoma treated with Cobalt chloride to mimic the hypoxia-like response of transcatheter arterial chemoembolization.
    2. DNAH14 variants are associated with neurodevelopmental disorders.
      Title: DNAH14 variants are associated with neurodevelopmental disorders.
    3. Clinical and Genetic Spectrum of Children With Primary Ciliary Dyskinesia in China.
      Title: Clinical and Genetic Spectrum of Children With Primary Ciliary Dyskinesia in China.
    4. Genetic variants within DNAH6, DNAH14, and DNAAF3 are associated with variation in lung function among persons with cystic fibrosis.
      Title: Variation in Cilia Protein Genes and Progression of Lung Disease in Cystic Fibrosis.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC27277, MGC51214, MGC149665, MGC149666, DKFZp781B1548

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dynein intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dynein light intermediate chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables minus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium movement involved in cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in 9+2 motile cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of dynein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    dynein axonemal heavy chain 14
    Names
    axonemal beta dynein heavy chain 14
    ciliary dynein heavy chain 14
    dynein heavy chain 14, axonemal
    dynein, axonemal, heavy polypeptide 14
    NP_001138626.1
    NP_001336840.1
    NP_001336841.1
    NP_001354408.1
    NP_001354410.1
    NP_659426.2
    XP_006711798.1
    XP_011542360.1
    XP_011542361.1
    XP_011542363.1
    XP_011542364.1
    XP_011542365.1
    XP_011542366.1
    XP_011542367.1
    XP_011542368.1
    XP_011542369.1
    XP_011542371.1
    XP_011542372.1
    XP_011542373.1
    XP_011542374.1
    XP_011542375.1
    XP_011542376.1
    XP_011542378.1
    XP_011542383.1
    XP_016855784.1
    XP_016855785.1
    XP_016855786.1
    XP_016855787.1
    XP_016855788.1
    XP_047301580.1
    XP_047301627.1
    XP_054190324.1
    XP_054190325.1
    XP_054190326.1
    XP_054190327.1
    XP_054190328.1
    XP_054190329.1
    XP_054190330.1
    XP_054190331.1
    XP_054190332.1
    XP_054190333.1
    XP_054190334.1
    XP_054190335.1
    XP_054190336.1
    XP_054190337.1
    XP_054190338.1
    XP_054190339.1
    XP_054190340.1
    XP_054190341.1
    XP_054190342.1
    XP_054190343.1
    XP_054190344.1
    XP_054190345.1
    XP_054190346.1
    XP_054190347.1
    XP_054190348.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_053088.1 RefSeqGene

      Range
      6254..475865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145154.3 → NP_001138626.1  dynein axonemal heavy chain 14 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL590547, BC042869, BC119716
      Consensus CDS
      CCDS44322.1
      UniProtKB/Swiss-Prot
      Q0VDD8
      Related
      ENSP00000383737.3, ENST00000400952.7

    2. NM_001349911.2 → NP_001336840.1  dynein axonemal heavy chain 14 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC093560, AL590547
      Consensus CDS
      CCDS86053.1
      UniProtKB/TrEMBL
      M9MMK7
      Related
      ENSP00000355814.1, ENST00000366849.5

    3. NM_001349912.2 → NP_001336841.1  dynein axonemal heavy chain 14 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC093560

    4. NM_001367479.1 → NP_001354408.1  dynein axonemal heavy chain 14 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC092811, AC093560, AL162738, AL357912, AL590547, AL596134, AL645769
      Consensus CDS
      CCDS91163.1
      UniProtKB/TrEMBL
      A0A804HLD3
      Related
      ENSP00000508305.1, ENST00000682510.1

    5. NM_001367481.1 → NP_001354410.1  dynein axonemal heavy chain 14 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC093560

    6. NM_144989.3 → NP_659426.2  dynein axonemal heavy chain 14 isoform 3

      See identical proteins and their annotated locations for NP_659426.2

      Status: VALIDATED

      Source sequence(s)
      AC093560, BC017415, BC119716, CA389321, DB443048
      Consensus CDS
      CCDS41472.1
      UniProtKB/Swiss-Prot
      Q0VDD8
      Related
      ENSP00000355815.3, ENST00000366850.7

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      224929654..225399286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011544062.3 → XP_011542364.1  dynein axonemal heavy chain 14 isoform X8

      Conserved Domains (5) summary
      pfam03028
      Location:3778 → 4552
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:992 → 1395
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3003 → 3337
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3363 → 3578
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1527 → 1754
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. XM_011544067.3 → XP_011542369.1  dynein axonemal heavy chain 14 isoform X13

      Conserved Domains (5) summary
      pfam03028
      Location:3778 → 4528
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:992 → 1395
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3003 → 3337
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3363 → 3578
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1527 → 1754
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    3. XM_017000296.2 → XP_016855785.1  dynein axonemal heavy chain 14 isoform X5

    4. XM_011544065.3 → XP_011542367.1  dynein axonemal heavy chain 14 isoform X11

      Conserved Domains (5) summary
      pfam03028
      Location:3714 → 4540
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:992 → 1395
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2939 → 3273
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3299 → 3514
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1527 → 1754
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    5. XM_011544069.3 → XP_011542371.1  dynein axonemal heavy chain 14 isoform X15

      Conserved Domains (5) summary
      pfam03028
      Location:3660 → 4486
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:992 → 1395
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2885 → 3219
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3245 → 3460
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1527 → 1754
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    6. XM_006711735.4 → XP_006711798.1  dynein axonemal heavy chain 14 isoform X4

      Related
      ENSP00000414402.1, ENST00000430092.5
      Conserved Domains (5) summary
      pfam03028
      Location:3747 → 4573
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:992 → 1395
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2972 → 3306
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3332 → 3547
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1527 → 1754
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    7. XM_011544064.3 → XP_011542366.1  dynein axonemal heavy chain 14 isoform X10

      Conserved Domains (5) summary
      pfam03028
      Location:3722 → 4548
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:992 → 1395
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2947 → 3281
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3307 → 3522
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1527 → 1754
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    8. XM_011544058.3 → XP_011542360.1  dynein axonemal heavy chain 14 isoform X1

      Conserved Domains (5) summary
      pfam03028
      Location:3777 → 4603
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:992 → 1395
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:3002 → 3336
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3362 → 3577
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1527 → 1754
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    9. XM_011544063.3 → XP_011542365.1  dynein axonemal heavy chain 14 isoform X9

      Conserved Domains (5) summary
      pfam03028
      Location:3725 → 4551
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:992 → 1395
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2950 → 3284
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3310 → 3525
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1527 → 1754
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    10. XM_017000297.2 → XP_016855786.1  dynein axonemal heavy chain 14 isoform X7

    11. XM_011544059.3 → XP_011542361.1  dynein axonemal heavy chain 14 isoform X2

      Conserved Domains (5) summary
      pfam03028
      Location:3762 → 4588
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:992 → 1395
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2987 → 3321
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3347 → 3562
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1527 → 1754
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    12. XM_011544066.3 → XP_011542368.1  dynein axonemal heavy chain 14 isoform X12

      Conserved Domains (5) summary
      pfam03028
      Location:3706 → 4532
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:992 → 1395
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2931 → 3265
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3291 → 3506
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1527 → 1754
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    13. XM_011544061.3 → XP_011542363.1  dynein axonemal heavy chain 14 isoform X6

      Conserved Domains (5) summary
      pfam03028
      Location:3743 → 4569
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:992 → 1395
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2968 → 3302
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3328 → 3543
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1527 → 1719
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    14. XM_017000295.2 → XP_016855784.1  dynein axonemal heavy chain 14 isoform X3

    15. XM_011544070.3 → XP_011542372.1  dynein axonemal heavy chain 14 isoform X16

      Conserved Domains (5) summary
      pfam03028
      Location:3652 → 4478
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:866 → 1269
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2877 → 3211
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3237 → 3452
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1401 → 1628
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    16. XM_011544072.3 → XP_011542374.1  dynein axonemal heavy chain 14 isoform X18

      Conserved Domains (5) summary
      pfam03028
      Location:3339 → 4165
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:553 → 956
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2564 → 2898
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:2924 → 3139
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1088 → 1315
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    17. XM_011544071.3 → XP_011542373.1  dynein axonemal heavy chain 14 isoform X17

      Conserved Domains (5) summary
      pfam03028
      Location:3602 → 4428
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:816 → 1219
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2827 → 3161
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:3187 → 3402
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:1351 → 1578
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    18. XM_047445624.1 → XP_047301580.1  dynein axonemal heavy chain 14 isoform X14

    19. XM_017000298.2 → XP_016855787.1  dynein axonemal heavy chain 14 isoform X20

    20. XM_011544073.3 → XP_011542375.1  dynein axonemal heavy chain 14 isoform X19

      Conserved Domains (5) summary
      pfam03028
      Location:3194 → 4020
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:408 → 811
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2419 → 2753
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:2779 → 2994
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:943 → 1170
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    21. XM_011544074.3 → XP_011542376.1  dynein axonemal heavy chain 14 isoform X21

      Conserved Domains (5) summary
      pfam03028
      Location:2984 → 3810
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:198 → 601
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:2209 → 2543
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:2569 → 2784
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:733 → 960
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    22. XM_011544076.2 → XP_011542378.1  dynein axonemal heavy chain 14 isoform X22

      Conserved Domains (5) summary
      pfam03028
      Location:2727 → 3553
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam08393
      Location:1 → 344
      DHC_N2; Dynein heavy chain, N-terminal region 2
      pfam12777
      Location:1952 → 2286
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:2312 → 2527
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:476 → 703
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    23. XM_017000299.2 → XP_016855788.1  dynein axonemal heavy chain 14 isoform X23

    24. XM_011544081.2 → XP_011542383.1  dynein axonemal heavy chain 14 isoform X24

      Conserved Domains (4) summary
      pfam03028
      Location:1964 → 2790
      Dynein_heavy; Dynein heavy chain and region D6 of dynein motor
      pfam12777
      Location:1189 → 1523
      MT; Microtubule-binding stalk of dynein motor
      pfam12781
      Location:1549 → 1764
      AAA_9; ATP-binding dynein motor region D5
      cl21455
      Location:916 → 1177
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    25. XM_047445671.1 → XP_047301627.1  dynein axonemal heavy chain 14 isoform X25

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      224118326..224587576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054334356.1 → XP_054190331.1  dynein axonemal heavy chain 14 isoform X8

    2. XM_054334361.1 → XP_054190336.1  dynein axonemal heavy chain 14 isoform X13

    3. XM_054334353.1 → XP_054190328.1  dynein axonemal heavy chain 14 isoform X5

    4. XM_054334359.1 → XP_054190334.1  dynein axonemal heavy chain 14 isoform X11

    5. XM_054334363.1 → XP_054190338.1  dynein axonemal heavy chain 14 isoform X15

    6. XM_054334352.1 → XP_054190327.1  dynein axonemal heavy chain 14 isoform X4

    7. XM_054334358.1 → XP_054190333.1  dynein axonemal heavy chain 14 isoform X10

    8. XM_054334349.1 → XP_054190324.1  dynein axonemal heavy chain 14 isoform X1

    9. XM_054334357.1 → XP_054190332.1  dynein axonemal heavy chain 14 isoform X9

    10. XM_054334355.1 → XP_054190330.1  dynein axonemal heavy chain 14 isoform X7

    11. XM_054334350.1 → XP_054190325.1  dynein axonemal heavy chain 14 isoform X2

    12. XM_054334360.1 → XP_054190335.1  dynein axonemal heavy chain 14 isoform X12

    13. XM_054334354.1 → XP_054190329.1  dynein axonemal heavy chain 14 isoform X6

    14. XM_054334351.1 → XP_054190326.1  dynein axonemal heavy chain 14 isoform X3

    15. XM_054334364.1 → XP_054190339.1  dynein axonemal heavy chain 14 isoform X16

    16. XM_054334366.1 → XP_054190341.1  dynein axonemal heavy chain 14 isoform X18

    17. XM_054334365.1 → XP_054190340.1  dynein axonemal heavy chain 14 isoform X17

    18. XM_054334362.1 → XP_054190337.1  dynein axonemal heavy chain 14 isoform X14

    19. XM_054334368.1 → XP_054190343.1  dynein axonemal heavy chain 14 isoform X20

    20. XM_054334367.1 → XP_054190342.1  dynein axonemal heavy chain 14 isoform X19

    21. XM_054334369.1 → XP_054190344.1  dynein axonemal heavy chain 14 isoform X21

    22. XM_054334370.1 → XP_054190345.1  dynein axonemal heavy chain 14 isoform X22

    23. XM_054334371.1 → XP_054190346.1  dynein axonemal heavy chain 14 isoform X23

    24. XM_054334372.1 → XP_054190347.1  dynein axonemal heavy chain 14 isoform X24

    25. XM_054334373.1 → XP_054190348.1  dynein axonemal heavy chain 14 isoform X25

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001373.1: Suppressed sequence

      Description
      NM_001373.1: This RefSeq was removed because there is insufficient support for the transcript and protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q0VDD8.3 GenPept UniProtKB/Swiss-Prot:Q0VDD8

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