KIFC1 kinesin family member C1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIFC1provided by HGNC
Official Full Name: kinesin family member C1provided by HGNC
Primary source: HGNC:HGNC:6389
See related: Ensembl:ENSG00000237649 MIM:603763; AllianceGenome:HGNC:6389
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HSET; KNSL2
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and minus-end-directed microtubule motor activity. Involved in mitotic metaphase chromosome alignment and mitotic spindle assembly. Located in membrane. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in bone marrow (RPKM 10.5), lymph node (RPKM 9.0) and 15 other tissues See more
Orthologs: all
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Genomic context

Location:: 6p21.32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (33391461..33409896)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (33212742..33231258)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (33359600..33377673)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CDK1 promotes the phosphorylation of KIFC1 to regulate the tumorgenicity of endometrial carcinoma.
Title: CDK1 promotes the phosphorylation of KIFC1 to regulate the tumorgenicity of endometrial carcinoma.
A novel role for KIFC1-MYH9 interaction in triple-negative breast cancer aggressiveness and racial disparity.
Title: A novel role for KIFC1-MYH9 interaction in triple-negative breast cancer aggressiveness and racial disparity.
The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to the malignant behavior of pancreatic cancer.
Title: The DDX6/KIFC1 signaling axis, as regulated by YY1, contributes to the malignant behavior of pancreatic cancer.
A comprehensive analysis of the prognostic and immunotherapeutic characteristics of KIFC1 in pan-cancer and its role in the malignant phenotype of pancreatic cancer.
Title: A comprehensive analysis of the prognostic and immunotherapeutic characteristics of KIFC1 in pan-cancer and its role in the malignant phenotype of pancreatic cancer.
Kinesin Family Member C1 (KIFC1/HSET) Underlies Aggressive Disease in Androgen Receptor-Low and Basal-Like Triple-Negative Breast Cancers.
Title: Kinesin Family Member C1 (KIFC1/HSET) Underlies Aggressive Disease in Androgen Receptor-Low and Basal-Like Triple-Negative Breast Cancers.
DNA methylation of KIFC1 gene in determination of histological diagnosis, prognosis and metastasis of lung cancer.
Title: DNA methylation of KIFC1 gene in determination of histological diagnosis, prognosis and metastasis of lung cancer.
Kinesin Family Member C1 Overexpression Exerts Tumor-Promoting Properties in Head and Neck Squamous Cell Carcinoma via the Rac1/Wnt/beta-catenin Pathway.
Title: Kinesin Family Member C1 Overexpression Exerts Tumor-Promoting Properties in Head and Neck Squamous Cell Carcinoma via the Rac1/Wnt/β-catenin Pathway.
The Roles of KIFC1 in the Development of Osteosarcoma: Characterization of Potential Therapeutic Targets.
Title: The Roles of KIFC1 in the Development of Osteosarcoma: Characterization of Potential Therapeutic Targets.
Mechanism of spindle pole organization and instability in human oocytes.
Title: Mechanism of spindle pole organization and instability in human oocytes.
Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer.
Title: Increased expression levels of AURKA and KIFC1 are promising predictors of progression and poor survival associated with gastric cancer.

Submit: New GeneRIF Correction See all GeneRIFs (46)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	HIV-1 Vpr upregulates KIFC1 in HeLa cells within 12 hours of exposure	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-D14678 (e-PCR)
- UniSTS:32835

UniSTS:236125 (e-PCR)
- UniSTS:236125

RH36517 (e-PCR)
- UniSTS:76154

D6S1834 (e-PCR)
- UniSTS:20155

AL035165 (e-PCR)
- UniSTS:94680

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	NAS Non-traceable Author Statement more info	PubMed
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic sister chromatid segregation	NAS Non-traceable Author Statement more info	PubMed
involved_in mitotic spindle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	HDA more info	PubMed
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule organizing center	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIFC1

Names: kinesin-like 2; kinesin-like protein 2; kinesin-related protein HSET

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_002263.4 → NP_002254.2 kinesin-like protein KIFC1

See identical proteins and their annotated locations for NP_002254.2

Status: VALIDATED

Source sequence(s)

AI990093, BC063567, BE885900

Consensus CDS

CCDS34430.1

UniProtKB/Swiss-Prot

O60887, Q14834, Q4KMP0, Q5SU09, Q6GMS7, Q6P4A5, Q9BW19, Q9UQP7

UniProtKB/TrEMBL

A0A024RCS7, A0A1U9X7X5

Related

ENSP00000393963.2, ENST00000428849.7

Conserved Domains (2) summary

cd01366
Location:308 → 665

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

cl25732
Location:138 → 312

SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

33391461..33409896

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017010837.2 → XP_016866326.2 kinesin-like protein KIFC1 isoform X3

UniProtKB/TrEMBL

A0A1U9X7X5
XM_011514585.2 → XP_011512887.1 kinesin-like protein KIFC1 isoform X1

See identical proteins and their annotated locations for XP_011512887.1

UniProtKB/TrEMBL

A0A1U9X7X5

Conserved Domains (5) summary

smart00129
Location:310 → 666

KISc; Kinesin motor, catalytic domain. ATPase

cd01366
Location:308 → 659

KISc_C_terminal; Kinesin motor domain, KIFC2/KIFC3/ncd-like carboxy-terminal kinesins

pfam16796
Location:297 → 317

Microtub_bd; Microtubule binding

cl01090
Location:215 → 268

SlyX; SlyX

cl02488
Location:145 → 294

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
XM_011514587.3 → XP_011512889.1 kinesin-like protein KIFC1 isoform X2

See identical proteins and their annotated locations for XP_011512889.1

Conserved Domains (1) summary

cl22853
Location:250 → 405

Motor_domain; Myosin and Kinesin motor domain

Reference GRCh38.p14 ALT_REF_LOCI_6

Genomic

NT_167248.2 Reference GRCh38.p14 ALT_REF_LOCI_6

Range

4585788..4604282

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331079.1 → XP_054187054.1 kinesin-like protein KIFC1 isoform X5

UniProtKB/TrEMBL

A0A1U9X7X5
XM_054331078.1 → XP_054187053.1 kinesin-like protein KIFC1 isoform X1

UniProtKB/TrEMBL

A0A1U9X7X5
XM_054331081.1 → XP_054187056.1 kinesin-like protein KIFC1 isoform X2
XM_054331077.1 → XP_054187052.1 kinesin-like protein KIFC1 isoform X4

UniProtKB/TrEMBL

A0A1U9X7X5
XM_054331080.1 → XP_054187055.1 kinesin-like protein KIFC1 isoform X6

Reference GRCh38.p14 ALT_REF_LOCI_7

Genomic

NT_167249.2 Reference GRCh38.p14 ALT_REF_LOCI_7

Range

4840156..4858594

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054331343.1 → XP_054187318.1 kinesin-like protein KIFC1 isoform X3

UniProtKB/TrEMBL

A0A1U9X7X5
XM_054331342.1 → XP_054187317.1 kinesin-like protein KIFC1 isoform X1

UniProtKB/TrEMBL

A0A1U9X7X5
XM_054331344.1 → XP_054187319.1 kinesin-like protein KIFC1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

NC_060930.1 Alternate T2T-CHM13v2.0

Range

33212742..33231258

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054355376.1 → XP_054211351.1 kinesin-like protein KIFC1 isoform X8

UniProtKB/TrEMBL

A0A1U9X7X5
XM_054355375.1 → XP_054211350.1 kinesin-like protein KIFC1 isoform X1

UniProtKB/TrEMBL

A0A1U9X7X5
XM_054355378.1 → XP_054211353.1 kinesin-like protein KIFC1 isoform X2
XM_054355374.1 → XP_054211349.1 kinesin-like protein KIFC1 isoform X7

UniProtKB/TrEMBL

A0A1U9X7X5
XM_054355377.1 → XP_054211352.1 kinesin-like protein KIFC1 isoform X9