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    CEACAM21 CEA cell adhesion molecule 21 [ Homo sapiens (human) ]

    Gene ID: 90273, updated on 27-Nov-2024

    Summary

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    Official Symbol
    CEACAM21provided by HGNC
    Official Full Name
    CEA cell adhesion molecule 21provided by HGNC
    Primary source
    HGNC:HGNC:28834
    See related
    Ensembl:ENSG00000007129 MIM:618191; AllianceGenome:HGNC:28834
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEACAM3; R29124_1
    Summary
    Predicted to be involved in T cell activation. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in lymph node (RPKM 2.0), bone marrow (RPKM 1.9) and 15 other tissues See more
    Orthologs
    all
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    Genomic context

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    See CEACAM21 in Genome Data Viewer
    Location:
    19q13.2
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (41549518..41586844)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (44371274..44408596)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (42055886..42093197)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pleckstrin homology domain containing A3 pseudogene 1 Neighboring gene long intergenic non-protein coding RNA 1480 Neighboring gene Sharpr-MPRA regulatory region 9744 Neighboring gene RNA, 28S ribosomal pseudogene Neighboring gene Sharpr-MPRA regulatory region 9748 Neighboring gene uncharacterized LOC105372404 Neighboring gene CEA cell adhesion molecule pseudogene 3 Neighboring gene DnaJ heat shock protein family (Hsp40) member C19 pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The old CEACAMs find their new role in tumor immunotherapy. Han ZW, et al. Invest New Drugs, 2020 Dec. PMID 32488569
    2. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Amin Al Olama A, et al. Hum Mol Genet, 2013 Jan 15. PMID 23065704, Free PMC Article
    3. DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population. Alkelai A, et al. Int J Neuropsychopharmacol, 2012 May. PMID 21682944
    4. Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Ito T, et al. Nat Genet, 2021 Dec. PMID 34857952
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study revealed CEACAM21 as novel schizophrenia candidate genes in the Jewish population
      Title: DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.
    EBI GWAS Catalog
    DOCK4 and CEACAM21 as novel schizophrenia candidate genes in the Jewish population.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ13540, MGC119874, AC006129.2

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in T cell activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carcinoembryonic antigen-related cell adhesion molecule 21
    Names
    carcinoembryonic antigen related cell adhesion molecule 21

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098506.4 → NP_001091976.3  carcinoembryonic antigen-related cell adhesion molecule 21 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001091976.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC243960, AY358084, BC012001, BC106727
      Consensus CDS
      CCDS46086.1
      UniProtKB/Swiss-Prot
      B7WNQ6, O75296, Q3KPI0, Q6UY47, Q96ER7
      UniProtKB/TrEMBL
      A0A0G2JSC8
      Related
      ENSP00000385739.2, ENST00000401445.4
      Conserved Domains (2) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      cl11960
      Location:142 → 232
      Ig; Immunoglobulin domain

    2. NM_001288773.3 → NP_001275702.2  carcinoembryonic antigen-related cell adhesion molecule 21 isoform 3

      See identical proteins and their annotated locations for NP_001275702.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains multiple differences in the 5' UTR and 5' coding region, compared to variant 1, and initiates translation at an alternate start codon. The resulting isoform (3) is shorter and has a different N-terminus, compared to isoform 1.
      Source sequence(s)
      AK023602, AY358084, BC012001, BI913326
      Consensus CDS
      CCDS74373.1
      UniProtKB/TrEMBL
      A0A0B4J1W4
      Related
      ENSP00000384380.1, ENST00000407170.6
      Conserved Domains (2) summary
      cd00096
      Location:18 → 22
      Ig; Ig strand A [structural motif]
      cl11960
      Location:18 → 104
      Ig; Immunoglobulin domain

    3. NM_001290113.2 → NP_001277042.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform 4

      See identical proteins and their annotated locations for NP_001277042.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) uses two alternate splice sites in the 5' region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (4) is shorter and has a different N-terminus, compared to isoform 1.
      Source sequence(s)
      AC243960, AY358084, BC012001
      UniProtKB/Swiss-Prot
      Q3KPI0
      Conserved Domains (2) summary
      smart00410
      Location:24 → 104
      IG_like; Immunoglobulin like
      cl11960
      Location:14 → 104
      Ig; Immunoglobulin domain

    4. NM_033543.6 → NP_291021.4  carcinoembryonic antigen-related cell adhesion molecule 21 isoform 2 precursor

      See identical proteins and their annotated locations for NP_291021.4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC243960, AY358084, BC012001
      Consensus CDS
      CCDS46087.1
      UniProtKB/Swiss-Prot
      Q3KPI0
      Related
      ENSP00000187608.9, ENST00000187608.13
      Conserved Domains (3) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:152 → 232
      IG_like; Immunoglobulin like
      cl11960
      Location:142 → 232
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      41549518..41586844
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047439609.1 → XP_047295565.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X4

    2. XM_017027430.2 → XP_016882919.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

    3. XM_017027431.2 → XP_016882920.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

    4. XM_017027432.3 → XP_016882921.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

    5. XM_047439608.1 → XP_047295564.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

    6. XM_005278397.5 → XP_005278454.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X3

      See identical proteins and their annotated locations for XP_005278454.1

      UniProtKB/Swiss-Prot
      Q3KPI0
      Conserved Domains (3) summary
      cd05774
      Location:36 → 140
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:152 → 232
      IG_like; Immunoglobulin like
      cl11960
      Location:142 → 232
      Ig; Immunoglobulin domain

    7. XM_047439610.1 → XP_047295566.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JS40
      Related
      ENSP00000390697.1, ENST00000457737.5

    8. XM_047439611.1 → XP_047295567.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X6

      UniProtKB/TrEMBL
      A0A0B4J1W4

    9. XM_047439612.1 → XP_047295568.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X7

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187620.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      95157..132483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054329431.1 → XP_054185406.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

    2. XM_054329430.1 → XP_054185405.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

    3. XM_054329433.1 → XP_054185408.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

    4. XM_054329432.1 → XP_054185407.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

    5. XM_054329434.1 → XP_054185409.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X3

    6. XM_054329438.1 → XP_054185413.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X7

    7. XM_054329437.1 → XP_054185412.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X6

      UniProtKB/TrEMBL
      A0A0B4J1W4

    8. XM_054329435.1 → XP_054185410.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X4

    9. XM_054329436.1 → XP_054185411.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JS40

    RNA

    1. XR_008485641.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      44371274..44408596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322511.1 → XP_054178486.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X4

    2. XM_054322506.1 → XP_054178481.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

    3. XM_054322507.1 → XP_054178482.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X1

    4. XM_054322508.1 → XP_054178483.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

    5. XM_054322509.1 → XP_054178484.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X2

    6. XM_054322510.1 → XP_054178485.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X3

    7. XM_054322512.1 → XP_054178487.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JS40

    8. XM_054322513.1 → XP_054178488.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X6

      UniProtKB/TrEMBL
      A0A0B4J1W4

    9. XM_054322514.1 → XP_054178489.1  carcinoembryonic antigen-related cell adhesion molecule 21 isoform X7

    RNA

    1. XR_008485217.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3KPI0.3 GenPept UniProtKB/Swiss-Prot:Q3KPI0

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