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    raw raw [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 44851, updated on 17-Dec-2024

    Summary

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    Official Symbol
    rawprovided by FlyBase
    Official Full Name
    rawprovided by FlyBase
    Primary source
    FLYBASE:FBgn0003209
    Locus tag
    Dmel_CG12437
    See related
    AllianceGenome:FB:FBgn0003209
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG12437; CG9321; cyr; Dmel\CG12437; ensh; l(2)06825; l(2)k03514; Raw
    Summary
    Involved in several processes, including embryonic morphogenesis; gonad morphogenesis; and negative regulation of JNK cascade. Located in plasma membrane. Is expressed in several structures, including dorsal fold; embryonic midgut constriction 2; embryonic/larval midgut; epithelium; and presumptive embryonic/larval central nervous system. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See raw in Genome Data Viewer
    Location:
    29E4-29E6; 2-33 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (8709880..8740660, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (8709880..8740660, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Hepatocyte nuclear factor 4 Neighboring gene antisense RNA:CR44992 Neighboring gene Catalase B Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Raw regulates glial population of the eye imaginal disc. Hans VR, et al. Genesis, 2018 Oct. PMID 30288928
    2. Identification of raw as a regulator of glial development. Luong D, et al. PLoS One, 2018. PMID 29813126, Free PMC Article
    3. ribbon, raw, and zipper have distinct functions in reshaping the Drosophila cytoskeleton. Blake KJ, et al. Dev Genes Evol, 1999 Sep. PMID 10502112
    4. The products of ribbon and raw are necessary for proper cell shape and cellular localization of nonmuscle myosin in Drosophila. Blake KJ, et al. Dev Biol, 1998 Nov 1. PMID 9806782
    5. The genes raw and ribbon are required for proper shape of tubular epithelial tissues in Drosophila. Jack J, et al. Genetics, 1997 Sep. PMID 9286684, Free PMC Article

    See all (84) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The membrane protein Raw regulates dendrite pruning via the secretory pathway.
      Title: The membrane protein Raw regulates dendrite pruning via the secretory pathway.
    2. This study reports the identification of a new regulator of axonal degeneration: the transmembrane protein Raw. Raw regulates a cell autonomous nuclear signaling pathway whose yet unknown downstream effectors protect injured axons, dendrites, and synapses from degenerating
      Title: Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw.
    3. Raw is required for glial proliferation and migration in the developing visual system
      Title: Raw regulates glial population of the eye imaginal disc.
    4. raw as a regulator of glial development
      Title: Identification of raw as a regulator of glial development.
    5. Raw defines a potential point of convergence in distinct pathways shaping terminal dendrite patterning.
      Title: Coordinate control of terminal dendrite patterning and dynamics by the membrane protein Raw.
    6. loss of DE-cadherin strongly enhances the raw mutant gonad phenotype, while increasing DE-cadherin function rescues this phenotype
      Title: raw Functions through JNK signaling and cadherin-based adhesion to regulate Drosophila gonad morphogenesis.
    7. In Drosophila, quenching of basal activator protein 1 (AP-1) transcription factor activity serves as a prerequisite to its tight spatial and temporal control by the JNK (Jun N-terminal kinase) signaling cascade.
      Title: Raw mediates antagonism of AP-1 activity in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c8731490-8723170 mobile_element_type = transposon:Tirant{}328

    Gene Ontology Provided by FlyBase

    Process Evidence Code Pubs
    involved_in Malpighian tubule morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in central nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dorsal closure IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ectodermal digestive tract morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in germ-band shortening IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in gonad morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in hindgut morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in morphogenesis of an epithelium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in negative regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of Malpighian tubule diameter IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of cell shape IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    raw
    Names
    CG12437-PA
    CG12437-PB
    CG12437-PC
    CG12437-PD
    CG12437-PE
    cyrano
    ensheathment defects
    raw-PA
    raw-PB
    raw-PC
    raw-PD
    raw-PE

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      8709880..8740660 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_080050.3 → NP_524789.2  raw, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524789.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3Z6, Q9VLI5
      Related
      FBpp0079347
      Conserved Domains (1) summary
      pfam15891
      Location:168 → 257
      Nuc_deoxyri_tr2; Nucleoside 2-deoxyribosyltransferase like

    2. NM_001201804.1 → NP_001188733.1  raw, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188733.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NJ08, Q9VLI4
      Conserved Domains (1) summary
      pfam15891
      Location:352 → 441
      Nuc_deoxyri_tr2; Nucleoside 2-deoxyribosyltransferase like

    3. NM_164836.3 → NP_723416.1  raw, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723416.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NJ08, Q9VLI4
      Related
      FBpp0079348
      Conserved Domains (1) summary
      pfam15891
      Location:352 → 441
      Nuc_deoxyri_tr2; Nucleoside 2-deoxyribosyltransferase like

    4. NM_001298831.1 → NP_001285760.1  raw, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285760.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9NJ08, Q9VLI4
      Conserved Domains (1) summary
      pfam15891
      Location:352 → 441
      Nuc_deoxyri_tr2; Nucleoside 2-deoxyribosyltransferase like

    5. NM_001298830.1 → NP_001285759.1  raw, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285759.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U3Z6, X2J5A2
      Conserved Domains (1) summary
      pfam15891
      Location:195 → 284
      Nuc_deoxyri_tr2; Nucleoside 2-deoxyribosyltransferase like
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MT71 Q8MT71
    Q9NJ08 Q9NJ08
    Q9U3Z6 Q9U3Z6
    Q9VLI4 Q9VLI4
    Q9VLI5 Q9VLI5
    X2J5A2 X2J5A2

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