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    Pkn3 protein kinase N3 [ Mus musculus (house mouse) ]

    Gene ID: 263803, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pkn3provided by MGI
    Official Full Name
    protein kinase N3provided by MGI
    Primary source
    MGI:MGI:2388285
    See related
    Ensembl:ENSMUSG00000026785 AllianceGenome:MGI:2388285
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in epithelial cell migration and intracellular signal transduction. Predicted to be located in nucleus and perinuclear region of cytoplasm. Is expressed in several structures, including genitourinary system; heart; respiratory system; submandibular gland; and vascular system. Orthologous to human PKN3 (protein kinase N3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 8.5), subcutaneous fat pad adult (RPKM 6.3) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Pkn3 in Genome Data Viewer
    Location:
    2 B; 2 21.13 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (29967657..29981031)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (30077548..30091023)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene dynein 2 intermediate chain 2 Neighboring gene STARR-seq mESC enhancer starr_04082 Neighboring gene STARR-positive B cell enhancer ABC_E4426 Neighboring gene SET nuclear oncogene Neighboring gene STARR-positive B cell enhancer ABC_E8783 Neighboring gene STARR-positive B cell enhancer ABC_E3366 Neighboring gene zinc finger, DHHC domain containing 12 Neighboring gene zyg-11 related, cell cycle regulator Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:29979764-29979873 Neighboring gene STARR-seq mESC enhancer starr_04088 Neighboring gene STARR-positive B cell enhancer ABC_E4427 Neighboring gene TBC1 domain family, member 13 Neighboring gene reactive oxygen species modulator 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. PKN3 is the major regulator of angiogenesis and tumor metastasis in mice. Mukai H, et al. Sci Rep, 2016 Jan 8. PMID 26742562, Free PMC Article
    2. The interaction of PKN3 with RhoC promotes malignant growth. Unsal-Kacmaz K, et al. Mol Oncol, 2012 Jun. PMID 22217540, Free PMC Article
    3. PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase. Leenders F, et al. EMBO J, 2004 Aug 18. PMID 15282551, Free PMC Article
    4. Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling. Uehara S, et al. Sci Signal, 2017 Aug 29. PMID 28851822
    5. The interaction of p130Cas with PKN3 promotes malignant growth. Gemperle J, et al. Mol Oncol, 2019 Feb. PMID 30422386, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a novel interaction of p130Cas with Ser/Thr kinase PKN3, is reported.
      Title: The interaction of p130Cas with PKN3 promotes malignant growth.
    2. Pkn3 promotes bone resorption downstream of Wnt5a-Ror2-Rho signaling, and this pathway may be a therapeutic target for bone diseases such as osteoporosis, rheumatoid arthritis, and periodontal disease.
      Title: Protein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling.
    3. PKN3 is the major regulator of angiogenesis in humans and mice and tumor metastasis in mice.
      Title: PKN3 is the major regulator of angiogenesis and tumor metastasis in mice.
    4. Data demonstrate that PKN3 physically interacts with Rho-family GTPases, and preferentially with RhoC, a known mediator of tumor invasion and metastasis in epithelial cancers.
      Title: The interaction of PKN3 with RhoC promotes malignant growth.
    5. PKN3 might represent a preferred target for therapeutic intervention in cancers that lack tumor suppressor PTEN function or depend on chronic activation of phosphoinositide 3-kinase
      Title: PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (6)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC31699

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium,diacylglycerol-dependent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diacylglycerol-dependent, calcium-independent serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in epithelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epithelial cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase N3
    Names
    protein kinase PKN-beta
    protein kinase PKNbeta
    protein-kinase C-related kinase 3
    NP_722500.1
    XP_006498115.1
    XP_006498116.1
    XP_006498117.1
    XP_030107417.1
    XP_030107418.1
    XP_030107419.1
    XP_030107420.1
    XP_030107421.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153805.2 → NP_722500.1  serine/threonine-protein kinase N3

      See identical proteins and their annotated locations for NP_722500.1

      Status: VALIDATED

      Source sequence(s)
      BX005298
      Consensus CDS
      CCDS15867.1
      UniProtKB/Swiss-Prot
      Q8K045
      Related
      ENSMUSP00000041025.8, ENSMUST00000045246.8
      Conserved Domains (5) summary
      PTZ00263
      Location:544 → 868
      PTZ00263; protein kinase A catalytic subunit; Provisional
      cd11622
      Location:10 → 75
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd05589
      Location:548 → 873
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:90 → 163
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:321 → 408
      C2; C2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      29967657..29981031
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251558.2 → XP_030107418.1  serine/threonine-protein kinase N3 isoform X2

      Conserved Domains (4) summary
      cd11622
      Location:14 → 79
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd05589
      Location:575 → 900
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:94 → 167
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:348 → 435
      C2; C2 domain

    2. XM_006498053.5 → XP_006498116.1  serine/threonine-protein kinase N3 isoform X6

      See identical proteins and their annotated locations for XP_006498116.1

      Conserved Domains (4) summary
      cd11622
      Location:14 → 79
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd05589
      Location:552 → 877
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:94 → 167
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:325 → 412
      C2; C2 domain

    3. XM_030251559.2 → XP_030107419.1  serine/threonine-protein kinase N3 isoform X3

      Conserved Domains (4) summary
      cd11622
      Location:13 → 78
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd05589
      Location:574 → 899
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:93 → 166
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:347 → 434
      C2; C2 domain

    4. XM_030251561.2 → XP_030107421.1  serine/threonine-protein kinase N3 isoform X8

      Conserved Domains (5) summary
      cd11622
      Location:23 → 88
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      PRK14950
      Location:477 → 579
      PRK14950; DNA polymerase III subunits gamma and tau; Provisional
      cl00087
      Location:103 → 176
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:357 → 444
      C2; C2 domain
      cl21453
      Location:584 → 600
      PKc_like; Protein Kinases, catalytic domain

    5. XM_030251557.2 → XP_030107417.1  serine/threonine-protein kinase N3 isoform X1

      Conserved Domains (4) summary
      cd11622
      Location:23 → 88
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd05589
      Location:584 → 909
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:103 → 176
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:357 → 444
      C2; C2 domain

    6. XM_006498052.5 → XP_006498115.1  serine/threonine-protein kinase N3 isoform X5

      Conserved Domains (4) summary
      cd11622
      Location:23 → 88
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd05589
      Location:561 → 886
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:103 → 176
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:334 → 421
      C2; C2 domain

    7. XM_030251560.2 → XP_030107420.1  serine/threonine-protein kinase N3 isoform X4

      Conserved Domains (4) summary
      cd11622
      Location:10 → 75
      HR1_PKN_1; First Protein kinase C-related kinase homology region 1 (HR1) Rho-binding domain of Protein Kinase N
      cd05589
      Location:571 → 896
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:90 → 163
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:344 → 431
      C2; C2 domain

    8. XM_006498054.4 → XP_006498117.1  serine/threonine-protein kinase N3 isoform X7

      See identical proteins and their annotated locations for XP_006498117.1

      UniProtKB/TrEMBL
      Q3UQS3
      Related
      ENSMUST00000137240.8
      Conserved Domains (3) summary
      cd05589
      Location:426 → 751
      STKc_PKN; Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N
      cl00087
      Location:41 → 99
      HR1; Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases
      cl14603
      Location:199 → 286
      C2; C2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K045.1 GenPept UniProtKB/Swiss-Prot:Q8K045

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