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    Gmd GDP-mannose 4,6-dehydratase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33716, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gmdprovided by FlyBase
    Official Full Name
    GDP-mannose 4,6-dehydrataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031661
    Locus tag
    Dmel_CG8890
    See related
    AllianceGenome:FB:FBgn0031661
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Brazil nut; CG8890; Dm-gmd; Dmel\CG8890; DmGMD; gmd; GMD; l(2)SH1606; l(2)SH2 1606
    Summary
    Enables GDP-mannose 4,6-dehydratase activity. Involved in several processes, including 'de novo' GDP-L-fucose biosynthetic process; oogenesis; and positive regulation of Notch signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including adult head; anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; and ganglia. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Gmd in Genome Data Viewer
    Location:
    25B5-25B5; 2-14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4975300..4977023, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4975300..4977023, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene RNA polymerase I and III subunit C Neighboring gene lethal (2) 05714 Neighboring gene uncharacterized protein Neighboring gene mitochondrial ribosomal protein L28 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Drosophila neurally altered carbohydrate mutant has a defective Golgi GDP-fucose transporter. Geisler C, et al. J Biol Chem, 2012 Aug 24. PMID 22745127, Free PMC Article
    2. Cell biology. Does Notch take the sweet road to success? Lowe JB. Science, 2005 Mar 11. PMID 15761143
    3. Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc. Ishikawa HO, et al. Proc Natl Acad Sci U S A, 2005 Dec 20. PMID 16344471, Free PMC Article
    4. O-fucose monosaccharide of Drosophila Notch has a temperature-sensitive function and cooperates with O-glucose glycan in Notch transport and Notch signaling activation. Ishio A, et al. J Biol Chem, 2015 Jan 2. PMID 25378397, Free PMC Article
    5. Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster. Rhomberg S, et al. FEBS J, 2006 May. PMID 16650000

    See all (54) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cloning, purification and charactrization of GMD
      Title: Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables GDP-mannose 4,6-dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GDP-mannose 4,6-dehydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GDP-mannose 4,6-dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GDP-mannose 4,6-dehydratase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' GDP-L-fucose biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' GDP-L-fucose biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 'de novo' GDP-L-fucose biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in GDP-mannose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell fate commitment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of Notch signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    GDP-mannose 4,6-dehydratase
    Names
    CG8890-PA
    GDP-D-mannose 4,6-dehydratase
    GDP-mannose 4,6 dehydratase
    GDP-mannose 4,6-dehydrase
    GDP-mannose dehydratase
    Gmd-PA
    NP_608888.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4975300..4977023 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_135044.4 → NP_608888.2  GDP-mannose 4,6-dehydratase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608888.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q1H8X2, Q8T3U5, Q9VMW9
      UniProtKB/TrEMBL
      C7LA78
      Related
      FBpp0078685
      Conserved Domains (2) summary
      pfam16363
      Location:50 → 381
      GDP_Man_Dehyd; GDP-mannose 4,6 dehydratase
      cl21454
      Location:47 → 389
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VMW9.2 Q9VMW9

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