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    OPT3 oligopeptide transporter [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827332, updated on 18-Sep-2024

    Summary

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    Official Symbol
    OPT3
    Official Full Name
    oligopeptide transporter
    Primary source
    TAIR:AT4G16370
    Locus tag
    AT4G16370
    See related
    Araport:AT4G16370
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATOPT3; DL4215C; FCAALL.72; oligopeptide transporter
    Summary
    Encodes an oligopeptide transporter involved in metal homeostasis. It loads iron into the phloem, facilitates iron recirculation from the xylem to the phloem, and regulates both shoot-to-root iron signaling and iron redistribution from mature to developing tissues.
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    Genomic context

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    See OPT3 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (9247302..9250343, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SNF1-related protein kinase regulatory subunit beta-2 Neighboring gene ncRNA Neighboring gene Heavy metal transport/detoxification superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. RBP differentiation contributes to selective transmissibility of OPT3 mRNAs. Lv X, et al. Plant Physiol, 2021 Nov 3. PMID 34618059, Free PMC Article
    2. OPT3 is a component of the iron-signaling network between leaves and roots and misregulation of OPT3 leads to an over-accumulation of cadmium in seeds. Mendoza-Cózatl DG, et al. Mol Plant, 2014 Sep. PMID 24880337, Free PMC Article
    3. OPT3 Is a Phloem-Specific Iron Transporter That Is Essential for Systemic Iron Signaling and Redistribution of Iron and Cadmium in Arabidopsis. Zhai Z, et al. Plant Cell, 2014 May. PMID 24867923, Free PMC Article
    4. The Arabidopsis AtOPT3 protein functions in metal homeostasis and movement of iron to developing seeds. Stacey MG, et al. Plant Physiol, 2008 Feb. PMID 18083798, Free PMC Article
    5. Expression profiles of Arabidopsis thaliana in mineral deficiencies reveal novel transporters involved in metal homeostasis. Wintz H, et al. J Biol Chem, 2003 Nov 28. PMID 13129917

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RBP differentiation contributes to selective transmissibility of OPT3 mRNAs.
      Title: RBP differentiation contributes to selective transmissibility of OPT3 mRNAs.
    2. OPT3 is important for leaf phloem-loading of iron and plays a key role regulating Fe, Zn, and Cd distribution within the plant
      Title: OPT3 is a component of the iron-signaling network between leaves and roots and misregulation of OPT3 leads to an over-accumulation of cadmium in seeds.
    3. AtOPT3 plays a critical role in two important aspects of iron metabolism, namely, maintenance of whole-plant iron homeostasis and iron nutrition of developing seeds.
      Title: The Arabidopsis AtOPT3 protein functions in metal homeostasis and movement of iron to developing seeds.
    4. Transcription of At4g16370 is upregulated in Mn-, iron-, and copper-deficient plants. At4g16370 can rescue yeast CTR1 (copper deficient) and Smf1 (manganese deficient) mutants, suggesting a function in metal transport.
      Title: Expression profiles of Arabidopsis thaliana in mineral deficiencies reveal novel transporters involved in metal homeostasis.
    Submit: New GeneRIF Correction

    General gene information

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    NM_117732.7

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables oligopeptide transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oligopeptide transmembrane transporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables transition metal ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular monoatomic cation homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within xylem-to-phloem iron transport IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    oligopeptide transporter
    NP_567493.5
    • oligopeptide transporter (OPT3); CONTAINS InterPro DOMAIN/s: Tetrapeptide transporter, OPT1/isp4 (InterPro:IPR004648), Oligopeptide transporter OPT superfamily (InterPro:IPR004813); BEST Arabidopsis thaliana protein match is: oligopeptide transporter 2 (TAIR:AT1G09930.1); Has 1146 Blast hits to 1125 proteins in 109 species: Archae - 0; Bacteria - 26; Metazoa - 0; Fungi - 775; Plants - 337; Viruses - 0; Other Eukaryotes - 8 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      9247302..9250343 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_117732.7 → NP_567493.5  oligopeptide transporter [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567493.5

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JLS9, O23482, Q8H0V0, Q940I5
      UniProtKB/TrEMBL
      A0A178UX74
      Conserved Domains (1) summary
      cl14607
      Location:19 → 702
      OPT; OPT oligopeptide transporter protein
    Nucleotide Protein
    Heading Accession and Version

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