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    marchf8 membrane-associated ring finger (C3HC4) 8 [ Danio rerio (zebrafish) ]

    Gene ID: 567818, updated on 4-Jan-2025

    Summary

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    Official Symbol
    marchf8provided by ZNC
    Official Full Name
    membrane-associated ring finger (C3HC4) 8provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-080204-8
    See related
    Ensembl:ENSDARG00000062489 AllianceGenome:ZFIN:ZDB-GENE-080204-8
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    march8; zgc:171495
    Summary
    Predicted to enable MHC protein binding activity and ubiquitin protein ligase activity. Acts upstream of or within negative regulation of defense response to virus and protein ubiquitination. Predicted to be located in cytoplasmic vesicle and lysosomal membrane. Predicted to be active in early endosome membrane; late endosome membrane; and lysosome. Is expressed in blastomere and brain. Orthologous to human MARCHF8 (membrane associated ring-CH-type finger 8). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See marchf8 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (17752591..18011225, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (17621599..17880418, complement)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene novel protein similar to vertebrate neurofilament, medium polypeptide (NEFM) Neighboring gene voltage-dependent anion channel 2 Neighboring gene zinc finger, AN1-type domain 4 Neighboring gene WASH complex subunit 2C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Cell adhesion in zebrafish embryos is modulated by March 8. Kim MH, et al. PLoS One, 2014. PMID 24752240, Free PMC Article
    2. Zebrafish MARCH8 downregulates fish IFN response by targeting MITA and TBK1 for protein degradation. Zhao X, et al. Dev Comp Immunol, 2022 Oct. PMID 35764162
    3. Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1. Xiong ST, et al. Int J Biol Macromol, 2023 Jun 15. PMID 37054851
    4. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    5. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables MHC protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in antigen processing and presentation of peptide antigen via MHC class II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in late endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase MARCHF8
    NP_001154907.1
    NP_001314848.1
    XP_009305508.1
    XP_009305510.1
    XP_009305511.1
    XP_009305512.1
    XP_068069004.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161435.2 → NP_001154907.1  E3 ubiquitin-protein ligase MARCHF8 isoform 1

      See identical proteins and their annotated locations for NP_001154907.1

      Status: VALIDATED

      Source sequence(s)
      BX470214, BX901979
      UniProtKB/TrEMBL
      A0A8M1NT04, A0A8M3B7Y1, B8A530
      Related
      ENSDARP00000115648.1, ENSDART00000144813.3
      Conserved Domains (1) summary
      smart00744
      Location:74 → 122
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    2. NM_001327919.1 → NP_001314848.1  E3 ubiquitin-protein ligase MARCHF8 isoform 3

      Status: VALIDATED

      Source sequence(s)
      BX470214, BX901979
      UniProtKB/TrEMBL
      A0A286YAB5, A0A8M1P379
      Conserved Domains (1) summary
      smart00744
      Location:351 → 399
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      17752591..18011225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009307236.3 → XP_009305511.1  E3 ubiquitin-protein ligase MARCHF8 isoform X3

      UniProtKB/TrEMBL
      A0A8M3BEK3
      Conserved Domains (1) summary
      smart00744
      Location:351 → 399
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    2. XM_009307235.4 → XP_009305510.1  E3 ubiquitin-protein ligase MARCHF8 isoform X2

      UniProtKB/TrEMBL
      A0A8M3AZ09
      Conserved Domains (1) summary
      smart00744
      Location:351 → 399
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    3. XM_009307233.4 → XP_009305508.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      See identical proteins and their annotated locations for XP_009305508.1

      UniProtKB/TrEMBL
      A0A286YAB5, A0A8M1P379
      Related
      ENSDARP00000144109.2, ENSDART00000176027.2
      Conserved Domains (1) summary
      smart00744
      Location:351 → 399
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    4. XM_068212903.1 → XP_068069004.1  E3 ubiquitin-protein ligase MARCHF8 isoform X1

      UniProtKB/TrEMBL
      A0A286YAB5, A0A8M1P379

    5. XM_009307237.4 → XP_009305512.1  E3 ubiquitin-protein ligase MARCHF8 isoform X4

      UniProtKB/TrEMBL
      A0A8M3AYZ3
      Conserved Domains (1) summary
      smart00744
      Location:329 → 377
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001111193.1: Suppressed sequence

      Description
      NM_001111193.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein
    Heading Accession and Version

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