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    Serpinb10 serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10 [ Mus musculus (house mouse) ]

    Gene ID: 241197, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Serpinb10provided by MGI
    Official Full Name
    serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10provided by MGI
    Primary source
    MGI:MGI:2138648
    See related
    Ensembl:ENSMUSG00000092572 AllianceGenome:MGI:2138648
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830131G07; Serpinb10-ps
    Summary
    Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in extracellular space. Is expressed in several structures, including esophagus; liver lobe; oral epithelium; and skin. Orthologous to human SERPINB10 (serpin family B member 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Serpinb10 in Genome Data Viewer
    Location:
    1 E2.1; 1 50.34 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (107456724..107488469)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (107528994..107560742)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 7 Neighboring gene STARR-positive B cell enhancer mm9_chr1:109342973-109343273 Neighboring gene STARR-positive B cell enhancer mm9_chr1:109343789-109344089 Neighboring gene predicted gene, 24553 Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 2 Neighboring gene STARR-seq mESC enhancer starr_01868 Neighboring gene SCAN domain containing 3 pseudogene Neighboring gene serine (or cysteine) peptidase inhibitor, clade B, member 8 Neighboring gene STARR-seq mESC enhancer starr_01869 Neighboring gene STARR-seq mESC enhancer starr_01870 Neighboring gene predicted gene 15389

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells. Mo Y, et al. Respir Res, 2021 Jun 14. PMID 34126986, Free PMC Article
    2. Epithelial SERPINB10, a novel marker of airway eosinophilia in asthma, contributes to allergic airway inflammation. Mo Y, et al. Am J Physiol Lung Cell Mol Physiol, 2019 Jan 1. PMID 30382768
    3. Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus. Askew DJ, et al. Genomics, 2004 Jul. PMID 15203215
    4. Update of the human and mouse SERPIN gene superfamily. Heit C, et al. Hum Genomics, 2013 Oct 30. PMID 24172014, Free PMC Article
    5. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells.
      Title: SERPINB10 contributes to asthma by inhibiting the apoptosis of allergenic Th2 cells.
    2. Epithelial SERPINB10 contributes to allergic airway eosinophilic inflammation, at least in part, by regulating the expression of periostin and CCL26.
      Title: Epithelial SERPINB10, a novel marker of airway eosinophilia in asthma, contributes to allergic airway inflammation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables peptidase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of proteolysis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serpin B10
    Names
    serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 10, pseudogene
    serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160307.1 → NP_001153779.1  serpin B10 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 2 has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC148982, AK036537, AK052580
      Consensus CDS
      CCDS48338.1
      UniProtKB/Swiss-Prot
      Q8K1K6
      Conserved Domains (1) summary
      cl00137
      Location:1 → 320
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    2. NM_198028.3 → NP_932145.3  serpin B10 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC148982, AK036537, AK052580
      UniProtKB/Swiss-Prot
      Q8K1K6
      Related
      ENSMUSP00000141672.2, ENSMUST00000194951.3
      Conserved Domains (1) summary
      cl00137
      Location:1 → 357
      SERPIN; SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      107456724..107488469
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529597.4 → XP_006529660.1  serpin B10 isoform X1

      Conserved Domains (1) summary
      cl38926
      Location:1 → 277
      serpin; SERine Proteinase INhibitors (serpin) family

    2. XM_006529598.4 → XP_006529661.1  serpin B10 isoform X2

      Conserved Domains (1) summary
      cl38926
      Location:1 → 240
      serpin; SERine Proteinase INhibitors (serpin) family

    3. XM_006529599.1 → XP_006529662.1  serpin B10 isoform X3

      Conserved Domains (1) summary
      cl38926
      Location:1 → 268
      serpin; SERine Proteinase INhibitors (serpin) family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1K6.1 GenPept UniProtKB/Swiss-Prot:Q8K1K6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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