Hr78 Hormone-receptor-like in 78 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hr78provided by FlyBase
Official Full Name: Hormone-receptor-like in 78provided by FlyBase
Primary source: FLYBASE:FBgn0015239
Locus tag: Dmel_CG7199
See related: AllianceGenome:FB:FBgn0015239
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG7199; Dhr78; DHR78; Dmel\CG7199; HR78; Hr78D; NR2D1; XR78E/F
Summary: Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in liquid clearance, open tracheal system and regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including clypeo-labral primordium; embryonic epipharynx; embryonic hypopharynx; embryonic/larval midgut primordium; and gut section. Orthologous to several human genes including NR2C1 (nuclear receptor subfamily 2 group C member 1). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 78D4-78D4; 3-47 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (21494019..21497494, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (21487119..21490594, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

major role for DHR78 in promoting the expression of genes that are expressed in the midgut and genes in the ecdysone and Notch signaling pathways
Title: Adult functions for the Drosophila DHR78 nuclear receptor.
DHR78 and Moses proteins are coexpressed during development and colocalize to specific genomic targets in chromatin.
Title: Functional interactions between the Moses corepressor and DHR78 nuclear receptor regulate growth in Drosophila.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables nuclear receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-negative bacterium	HMP more info	PubMed
involved_in liquid clearance, open tracheal system	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in open tracheal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of innate immune response	HMP more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Hormone-receptor-like in 78

Names: CG7199-PA; CG7199-PB; CG7199-PC; CG7199-PD; CG7199-PE; CG7199-PF; Hr78-PA; Hr78-PB; Hr78-PC; Hr78-PD; Hr78-PE; Hr78-PF; X receptor at 78E/F

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

21494019..21497494 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_079479.5 → NP_524203.2 Hormone-receptor-like in 78, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524203.2

Status: REVIEWED

UniProtKB/TrEMBL

H9ZJM0

Related

FBpp0078046

Conserved Domains (2) summary

cd06952
Location:370 → 593

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cl02596
Location:47 → 131

NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers
NM_206415.3 → NP_996137.1 Hormone-receptor-like in 78, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_996137.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V288, Q24108, Q24142, Q8IPT4, Q9VP28

UniProtKB/TrEMBL

H9ZJM0, M9MS41

Conserved Domains (2) summary

cd06952
Location:372 → 595

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:47 → 133

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
NM_001202222.1 → NP_001189151.1 Hormone-receptor-like in 78, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189151.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V288, Q24108, Q24142, Q8IPT4, Q9VP28

UniProtKB/TrEMBL

H9ZJM0, M9MS41

Conserved Domains (2) summary

cd06952
Location:372 → 595

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:47 → 133

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
NM_001202223.1 → NP_001189152.1 Hormone-receptor-like in 78, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001189152.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V288, Q24108, Q24142, Q8IPT4, Q9VP28

UniProtKB/TrEMBL

H9ZJM0, M9MS41

Conserved Domains (2) summary

cd06952
Location:372 → 595

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:47 → 133

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
NM_168907.3 → NP_730636.1 Hormone-receptor-like in 78, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730636.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V288, Q24108, Q24142, Q8IPT4, Q9VP28

UniProtKB/TrEMBL

H9ZJM0, M9MS41

Related

FBpp0078044

Conserved Domains (2) summary

cd06952
Location:372 → 595

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:47 → 133

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers
NM_168908.3 → NP_730637.1 Hormone-receptor-like in 78, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730637.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4V288, Q24108, Q24142, Q8IPT4, Q9VP28

UniProtKB/TrEMBL

H9ZJM0, M9MS41

Related

FBpp0078045

Conserved Domains (2) summary

cd06952
Location:372 → 595

NR_LBD_TR2_like; The ligand binding domain of the orphan nuclear receptors TR4 and TR2

cd06967
Location:47 → 133

NR_DBD_TR2_like; DNA-binding domain of the TR2 and TR4 (human testicular receptor 2 and 4) is composed of two C4-type zinc fingers