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    Gucd1 guanylyl cyclase domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 687713, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gucd1provided by RGD
    Official Full Name
    guanylyl cyclase domain containing 1provided by RGD
    Primary source
    RGD:1597571
    See related
    EnsemblRapid:ENSRNOG00000049952 AllianceGenome:RGD:1597571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Involved in liver regeneration and response to cAMP. Orthologous to human GUCD1 (guanylyl cyclase domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Liver (RPKM 379.9), Kidney (RPKM 294.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gucd1 in Genome Data Viewer
    Location:
    20p12
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 20 NC_086038.1 (13145055..13155765)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 20 NC_051355.1 (13145617..13156330)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 20 NC_005119.4 (14096030..14102901)

    Chromosome 20 - NC_086038.1Genomic Context describing neighboring genes Neighboring gene gamma-glutamyltransferase 1 Neighboring gene uncharacterized LOC120098976 Neighboring gene leucine rich repeat containing 75B Neighboring gene small nuclear ribonucleoprotein D3 polypeptide Neighboring gene uncharacterized LOC102556392 Neighboring gene microRNA 327 Neighboring gene uncharacterized LOC102556333

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells. Bellet MM, et al. Cell Cycle, 2014. PMID 24743017, Free PMC Article
    2. Gene and alternative splicing annotation with AIR. Florea L, et al. Genome Res, 2005 Jan. PMID 15632090, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC189376

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in liver regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to cAMP IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein GUCD1
    Names
    guanylyl cyclase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001134997.3 → NP_001128469.2  protein GUCD1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020
      UniProtKB/TrEMBL
      B5DFC7

    2. NM_001412126.1 → NP_001399055.1  protein GUCD1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000020

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086038.1 Reference GRCr8

      Range
      13145055..13155765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039099073.2 → XP_038955001.1  protein GUCD1 isoform X2

      UniProtKB/TrEMBL
      A6JKK5
      Conserved Domains (1) summary
      pfam09778
      Location:1 → 197
      Guanylate_cyc_2; Guanylylate cyclase

    2. XM_039099072.2 → XP_038955000.1  protein GUCD1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASP6
      Related
      ENSRNOP00000097309.1, ENSRNOT00000115916.2
      Conserved Domains (1) summary
      pfam09778
      Location:94 → 307
      Guanylate_cyc_2; Guanylylate cyclase
    Nucleotide Protein Strain
    Heading Accession and Version

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