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    Zfp212 Zinc finger protein 212 [ Mus musculus (house mouse) ]

    Gene ID: 232784, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Zfp212provided by MGI
    Official Full Name
    Zinc finger protein 212provided by MGI
    Primary source
    MGI:MGI:2682609
    See related
    Ensembl:ENSMUSG00000052763 AllianceGenome:MGI:2682609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Znf212; mKIAA3011
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including dendrite development; general adaptation syndrome, behavioral process; and walking behavior. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Is expressed in central nervous system; early conceptus; and genitourinary system. Orthologous to human ZNF212 (zinc finger protein 212). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in thymus adult (RPKM 8.8), ovary adult (RPKM 7.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp212 in Genome Data Viewer
    Location:
    6 B2.3; 6 22.94 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (47897502..47909573)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (47920568..47932639)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 786 Neighboring gene zinc finger protein 398 Neighboring gene zinc finger protein 282 Neighboring gene predicted gene, 52899 Neighboring gene STARR-positive B cell enhancer ABC_E8099 Neighboring gene zinc finger protein 783 Neighboring gene zinc finger protein 956 Neighboring gene ribosomal protein S2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis. Zhao X, et al. Cell Res, 2014 Dec. PMID 25412662, Free PMC Article
    2. Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation. Khang R, et al. Sci Rep, 2021 Nov 23. PMID 34815492, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
    4. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    5. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.
      Title: Loss of zinc-finger protein 212 leads to Purkinje cell death and locomotive abnormalities with phospholipase D3 downregulation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within dendrite development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within general adaptation syndrome, behavioral process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuromuscular process controlling balance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within response to alcohol IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within walking behavior IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IC
    Inferred by Curator
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 212
    Names
    Zinc finger protein C2H2-150

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145881.1 → NP_001139353.1  zinc finger protein 212 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (2) that is 1 aa shorter than isoform 1
      Source sequence(s)
      AI646736, AK129476, BC064742, CJ054342
      UniProtKB/TrEMBL
      Q6ZPF1
      Conserved Domains (6) summary
      cd07765
      Location:142 → 180
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      smart00355
      Location:312 → 334
      ZnF_C2H2; zinc finger
      COG5048
      Location:357 → 473
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:367 → 387
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:425 → 445
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:437 → 462
      zf-H2C2_2; Zinc-finger double domain

    2. NM_145576.2 → NP_663551.2  zinc finger protein 212 isoform 1

      See identical proteins and their annotated locations for NP_663551.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AI646736, AK129476, BC064742, CF915685, CJ054342
      Consensus CDS
      CCDS51761.1
      UniProtKB/TrEMBL
      G3X8R7, Q6ZPF1
      Related
      ENSMUSP00000009411.8, ENSMUST00000009411.9
      Conserved Domains (5) summary
      cd07765
      Location:142 → 180
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
      COG5048
      Location:358 → 474
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:368 → 388
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:426 → 446
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:438 → 463
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      47897502..47909573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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